Pathophysiology of colorectal cancer

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Running Head: PATHOPHYSIOLOGY OF COLORECTAL CANCER
Pathophysiology of colorectal cancer
Student’s name:
3/13/2018

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PATHOPHYSIOLOGY OF COLORECTAL CANCER
Table of contents
Contents
Table of contents............................................................................................................. 1
Succinctly discuss the pathophysiology of cancer.....................................................................2
Tumors in general............................................................................................................ 2
Role of oncogenes, apoptosis, ell cycle and tumor suppressor gene............................................2
The pathophysiology of colorectal cancer in relation to the results”...............................................3
Moderately differentiated Adenocarcinoma grade three”............................................................3
Discus one chemotherapeutic agents available for Betty.............................................................4
Pharmacokinetics.......................................................................................................... 4
Side effects and contraindications..................................................................................... 4
Drug interactions.......................................................................................................... 5
Bibliography............................................................................................................... 6

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PATHOPHYSIOLOGY OF COLORECTAL CANCER
Succinctly discuss the pathophysiology of cancer
Tumors in general
Pathophysiology refers to the changes that occur in an organ resulting into signs and
symptoms which alter daily activities of living. Cancer refers to the uncontrolled growth of cells
within an organ, which can result in metastasis or remain benign; which depends on the
aggressiveness of the cancer.
Role of oncogenes, apoptosis, ell cycle and tumor suppressor gene
Cancers are caused by oncogenes which are products of mutation and are expressed in
increased levels. Apoptosis is a mechanism which gets rid of altered cells during the cell cycle
and normal aged cells which have served their purposes, an alteration during this process which
likely results from oncogenes, then the cells destined for destruction survive the process, and
they are allowed to replicate and multiply causing disruption to the normal physiologic process
eventually causing cancer (Baar. M, 2017)
Another factor responsible for the development of cancer is the tumor suppressor gene;
a gene that protects the cell from cancer. It contributes to development of cancer if it fails or if it
is impaired; however if it is fully viable, then the cells are safe. Also an alteration in the cell
cycle, which is a process that results in cell division and duplication of DNA, can cause cancer in