<p>Considering the insulin receptor as a prototypical RTK how can dysfunctional insulin signaling contribute to disease?</p>

Considering the insulin receptor as a prototypical RTK how can dysfunctional insulin signaling contribute to disease?

Insulin is secreted by beta cells in the pancreas and it is a very essential anabolic hormone that helps in the development of tissues and regulation.

Cell Biology - Insulin Receptor

Chem

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver and skeletal muscle triggers pathways that impair insulin signaling, leading to reduced muscle glucose uptake and decreased hepatic glycogen synthesis. Muscle insulin resistance, due to ectopic lipid, precedes liver insulin resistance and diverts ingested glucose to the liver, resulting in increased hepatic de novo lipogenesis and hyperlipidemia.

George County High School

Disease and Disorders

Nutrition and Wellness

Healthcare and Research

Biology

The Pathogenesis of Insulin Resistance: Integrating Signaling Pathways and Substrate Flux

Biochemistry 1

De La Salle University

Biochemistry Assignment (Doc)

Nutricion

This article discusses the interaction of insulin receptor (a protein) and insulin (a ligand). The interaction of the ligand and the receptor has a very important role to play in glucose homeostasis. The article also discusses the structure of the insulin receptor and transmembrane signaling, insulin receptor isoforms in physiology and disease, and the functional characterization of β2-adrenergic and insulin receptor heteromers.

Hartpury University and Hartpury College

Protein-Ligand Interaction

This is a lab report that discusses diabetes mellitus and GLP-1, a drug target for type 2 diabetes and obesity. The report explains the mechanisms of insulin production and insulin resistance, as well as the different types of medication used to treat diabetes. The report also describes the materials and methods used in a cell culture experiment to measure intracellular cAMP levels and the toxicity of certain compounds. Overall, the report highlights the potential of GLP-1 as a drug target for treating diabetes mellitus.

Cell Biology - Insulin Receptor

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