Type Of Anemic Disorder

Sickle Cell Anemia
Biology
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REPORT 1
Introduction
Sickle cell anemia is a homogenous type of anemic disorder which is caused when the
amino acid valine gets mutated and substituted by glutamic acid in amino acid chain coding
for hemoglobin (Jan C. ter Maaten, 2010). This report discusses the sickle cell anemia and
various aspects related to it such as its prevalence signs symptoms and its genotypic and
phenotypic characteristics. It also focuses on the measure that can be intervened to prevent its
transmission.
Review
Sickle cell is a genetic disorder that is triggered due to the mutation in the single
nucleotide in the gene and hence affecting the hemoglobin molecule in RBC in blood that
delivers oxygen gas to all different cells of the body parts. Single gene genetic disorder is
defined as the disorder caused due to change in only a single gene. It has been studied that the
sickle cell anemia trait is present on the recessive allele of the hemoglobin gene, which
indicates that there are two allelic copies of the recessive gene which are inherited from the
parents. Hence, it is a recessive allele disorder. It shows an autosomal type of recessive
pattern. The trait which is visible in an organism is called a dominant trait while which is
present in the gene but is not expressed is called a recessive trait. Moreover, traits that are
carried on the chromosome numbered 1 to 22 that do not determine the sex of the individual
are autosomal traits while those carried on the chromosomes X and Y are sex-linked
chromosomes (Odièvre, 2011).
The person with one allele as dominant and other one allele as recessive is a carrier of
the trait but does not have the disorder. In normal conditions, a person receives two copies of
the gene from its parents that significantly produces the beta-globin which is present in
hemoglobin. However, in the case of single-cell anemia person inherits one normal allele