Alzheimer’s Disease: Symptoms, Stages, Diagnosis and Treatment

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Added on  2023/05/28

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This educational brochure provides an overview of Alzheimer’s Disease, including its symptoms, stages, diagnosis and treatment options. It also delves into the pathophysiology and bio physiology of the disease. The brochure is a valuable resource for anyone seeking to understand Alzheimer’s Disease.

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Educational Brochure:
Alzheimer’s Disease
Name of the Student
Name of the University

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What is Alzheimer’s Disease ?
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What is Alzheimer’s Disease ?
Alzheimer's disease is a progressive disease in the
brain that has the characteristics of impairment in the
memory
It leads to disturbances and imbalance in planning,
reasoning, perception and language
It has been supported by most scientists that
accumulation of the beta-amyloid protein in human
brain is one of the main responsible reasons
It results in the nerve cell death that leads to the
impairment of body functions
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Stages of Alzheimer's disease

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Pathophysiology of Alzheimer's disease
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Pathophysiology of Alzheimer's disease
Abnormal and extra deposition of the folded A-beta and tau proteins (Beta-amyloid )
Pharmaceutical Treatments
Donepizel (under the brand name of Aricept for all stages of disease)
Galantamine (Razadyne) , for mild to moderate stages
Rivastigmine (Exelon), for mild to moderate stages
Non- Pharmaceutical Treatments
Reality orientation treatments
Behavioural Therapy
Cognitive Therapy
Multisensory Therapy
Aromatherapy
Emotion-oriented interventions
Caregiver training programs
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Diagnostic tests
The different levels of Diagnostic tests for Alzheimer’s disease are as followed,
Neurological exam (valuating the signal brain disorder, fluid accumulation in brain
and illness of impair memory. Apart from this, reflexes, muscle tone coordination,
speech and sensation are tested)
Home screening tests for dementia
Neuropsychological Screening Tests
Mental status tests (The symptom, date and time, memory power ability)
Mini-Mental State Exam (MMSE) and the Mini-Cog test
Computerised Bran mapping test
Mood assessment
Genetic testing based on computerised mechanisms
Brain imaging
Cerebrospinal Fluid (CSF) Tests
Positron Emission Tomography

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Bio physiology of the Alzheimer's disease
The fibrous deposits over accumulation of Beta-amyloid protein
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Bio physiology of the Alzheimer's disease
Due to the formation of the clumps there is
onset of abnormal behavioural pattern in the
human brain
The individual with the disease face problems in
planning, reasoning, perception and language
understanding
In severe cases, the abnormal biochemical
reactions also lead to hallucinations due to
destruction of the frontal lobe in the brain
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Diagnosis of Alzheimer's disease
This PET scan detects the abnormality in the brain due to Alzheimer's
disease detecting loss of function in brain’s temporal lobe

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Diagnosis of Alzheimer's disease
There are both medicinal and non-drug based
approaches for the treatment of the Alzheimer's
disease
Namenda (memantine) is prescribed for regulating
glutamate in brain
Razadyne is also prescribed for preventing the
breaking down of the acetylcholine in brain.
Razadyne capsule or tablet intake can delay the onset
of Alzheimer's disease by at least 12 months as well as
minimise its effect.
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References
Alzheimer’s, A. (2015). 2015 Alzheimer's disease facts and figures. Alzheimer's &
dementia: the journal of the Alzheimer's Association, 11(3), 332.
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., ... &
Cappa, S. (2014). Advancing research diagnostic criteria for Alzheimer's disease:
the IWG-2 criteria. The Lancet Neurology, 13(6), 614-629.
https://alzheimer-recherche.org/wp-content/uploads/2014/06/Lancet-Neuro-B.D
ubois-2014.pdf
Kumar, A., & Singh, A. (2015). A review on Alzheimer's disease pathophysiology and
its management: an update. Pharmacological Reports, 67(2), 195-203.
Selkoe, D. J., & Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25
years. EMBO molecular medicine, 8(6), 595-608.
http://embomolmed.embopress.org/content/8/6/595.abstract
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., ... &
Fratiglioni, L. (2016). Defeating Alzheimer's disease and other dementias: a
priority for European science and society. The Lancet Neurology, 15(5), 455-532.
https://www.alzheimer.dk/media/194511/lancet-neurology-comm-paper_april20
16_p455_532.pdf
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