Antibiotics and the Organism Assignment
Added on 2020-04-07
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Running head: ANTIBIOTICAntibioticsName of the StudentName of the UniversityAuthor’s note
ANTIBIOTIC1Table: The spectrum and mode of action of antibiotics and the organism it effects.AntibioticChemical classorClassificationSpectrum ofactivity (gram+, -, or broad)Mechanism of ActionReference usedCiprofloxacinTherapeutic:anti-infectivesPharmacologic:FlurorquilonesGram positiveand gramnegativeInhibits bacterial DNA synthesis viainhibiting bacterial DNA gyrase(topoisomerase ii). DNA gyrase helpsin the uncoiling of the bacterial DNAdouble helix during replication.Aldred, K. J., Kerns, R. J., & Osheroff, N.(2014). Mechanism of quinoloneactionandresistance.Biochemistry,vol. 53(10),pp. 1565-1574. 10.1021/bi5000564ColistinLipopolypeptideantibioticGram negativeInteracts with the anioniclipopolysaccharide layers of the outermembrane of gram negative bacteriaand increasest he cell permeabilitywhich promotes cell death.Liu, Y. Y., Wang, Y., Walsh, T. R., Yi, L. X.,Zhang, R., Spencer, J., ... & Yu, L. F.(2016). Emergence of plasmid-mediated colistin resistancemechanism MCR-1 in animals andhuman beings in China: amicrobiological and molecular
ANTIBIOTIC2biological study.The Lancet infectiousdiseases,vol. 16(2), pp. 161-168.https://doi.org/10.1016/S1473-3099(15)00424-7Moxalactamoxa-beta-lactamantibioticBroad spectrumactivity againstgram positiveand gramnegative aerobicand anaerobicbacteriaIt is a cephalosporin group of bacteria.It interferes the bactericidal activity viainhibiting the bacterial cell wallbiosynthesis. It tampers the cross-linking of the peptidoglycan layer. Italso activates autolysins causingbacterial cell lysis.Wolfe, S. (2016). Studies related to β-lactamcompounds.Current Trends inOrganic Synthesis, pp. 101.PenicillinTherapeutic:anti-infectivesPharmacologic:penicillinsMajority ofgram positiveand few gramnegativeBind to bacterial cell wall and preventsthe formation of peptidoglycan layervia inhibiting transpeptidoglycanbiosynthesis. It prevents the cross-linking of the peptidoglycan layerClarke, H. T. (Ed.). (2015).Chemistryof Penicillin. Princeton University Press.Polymyxin BLipopolypeptideantibioticGram negativeInteracts with the anioniclipopolysaccharide layers of the outerSandri, A. M., Landersdorfer, C. B., Jacob, J.,Boniatti, M. M., Dalarosa, M. G.,
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