Critical Analysis of Research Paper

Critical Analysis of
Research Paper

Table of Contents
INTRODUCTION...........................................................................................................................3
BACKGROUND.............................................................................................................................3
METHODS......................................................................................................................................4
Study design................................................................................................................................4
Search strategies..........................................................................................................................4
Eligibility criteria........................................................................................................................4
Data extraction and risk of bias assessment................................................................................4
Outcomes.....................................................................................................................................5
Statistics......................................................................................................................................5
RESULTS .......................................................................................................................................5
Characteristics.............................................................................................................................5
Comparison of dual anti platelet therapy versus non-anti platelet therapy 5 days before
surgery.........................................................................................................................................6
Comparison of DAPT versus aspirin therapy alone until surgery..............................................8
DISCUSSION AND LIMITATIONS.............................................................................................8
Limitations..................................................................................................................................9
CONCLUSION..............................................................................................................................10
REFERENCES..............................................................................................................................11

INTRODUCTION
Anti platelet drugs are helpful in preventing the clot formation in vessels which are
actually a main treatment surgery for different type of disorders such as angina, Non-ST and ST
evaluation in myocardial infraction. Currently the research is based on acute coronary syndrome
(ACS) which is actually a dual anti platelet theory, this Therapy help in reducing thrombotic and
ischaemic disorder (Degrauwe and et.al., 2017). The use of this Therapyis in patients who are
suffering from coronary artery bypass. This is useful and sometime it is treated as dual cutting
weapon, as on the one side this will reduce the of ischaemia but on the same side it will increase
the endangerment of bleeding. The aim of the present the research to present the systematic
review to get the answer that is dual anti platelet therapy with aspirin and clopidogrel are useful
or not in order to continue coronary artery bypass grafting. This project include, a deep
understanding of critical appraisal skills programme, discuss various methods use in addressing
research problems and discussion on strength and weakness of the strategies used in this
research.
BACKGROUND
Platelets are small particles in the blood which are clump together to form blood cots.
These blood cots can lead to heart attack which are comes in the result to sudden clotting which
are comes with coronary stent. Anti-platelets are the agents which are comes under the class of
drugs which actually increase the number of platelets in human body during surgery. This dual
anti platelets therapy combine with aspirin receptor which is consistently shown in order to
reduce recurrent major advices which reduce the impact of cardiovascular events in patents with
ACS or many other heart related issues (Gremmel and et.al., 2018). There are two type of anti
platelets medication is provided to patients which include one is aspirin, this is used by every
second doctor who give this to patients who are suffering from contrary artery diseases. Patients
who are suffering form heart diseases, stent and CABG can be treated through aspirin.
Another anti-platelets agent are P2Y inhibitor, this medication is usually prescribed for
months or years. This medication is mostly used or treated as the aspirin therapy. All these things
are necessary for the patients who are suffering from heart disease and many other type of
disease which are needed any bypass surgery in order to recover from that particular disease.

METHODS
Study design
In the present meta-analysis statement, data is studied on deep analysis of dual anti
platelet therapy. For this PICO presentation is explained:
P-stand for the patients who are suffering from, coronary artery bypass grafting. I-stand
for deep analysis of dual anti platelet therapy with aspirin and clopidogrel treatment. C-stand for
comparison with other control group or other treatments. And in last O-stand for mortality rates,
MI, cardiovascular accident, re-operations and many other issues which are occurring during
coronary bypass grafting.
Search strategies
This will include mainly three type of approaches; systematic search on the basis of
electronic data base, manual search in google and google scholar and different type of web pages
of reliable data which are required for conducting this research (Gupta and et.al., 2016) . Another
approach is screening of bibliography which is actually related to the data articles. All these data
are useful in screening of articles and journals.
Eligibility criteria
For the evaluation of dual anti platelets Therapy before conducting coronary artery
bypass grafting some of the eligibility criteria are use which include clinical trials, quasi-
experimental trial and controlled studies. This study include the use of aspirin and clopidrel
alone as a treatment groups, meanwhile in this research studies of control group and restricted
articles were excluded. All these criteria is helpful for the doctors to select patients who are
going to be treated through this dual anti-platelets therapy.
Data extraction and risk of bias assessment
This research record two independent reviewers who screened the title and abstract the
research as here the data is summarised and extracted in data extraction form. The extracted data
is including first author's name, publication year, country, sample size, age, time period of
between discontinuation and surgery, outcome of the surgery (Kargiotis and Tsivgoulis, G. 2021)
. All the data which are extracted in this research is found to be authenticate and valid. As proper
journals and bibliography is used to find out the accurate data.