Crohn's Disease: Pathogenesis, Symptoms, Treatment, and Lifestyle Habits

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02 Apr 2019
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Abstract
Crohn’s disease has an occurrence rate of 10.6 per 100,000 population and is considered as an
autoimmune and chronic complication. Among women, the symptoms vary than men, which is
associated with the changes in the hormonal level. In the present report, the discussion is focused
on the pathogenesis, symptoms, treatment measures, and lifestyle habits that are associated with
this disease.
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Introduction
Crohn's disease is an inflammatory bowel disease (IBD), in which the inflammation in
the digestive tract leads to debilitating and painful complications. The inflammation mainly
spread to the deep layers of bowel tissues (Al-Hussaini et al., 2016). Until date, there exists no
particular cure, however, therapeutic measures can reduce the symptoms. This is a chronic
condition which affects the digestive system and occurs when the body's immune system act
against the mucous system of the gut.
Population at risk
Every year, approximately 31000 new cases appear that are related to Crohn's disease.
The incidence rate is 10.6 per 100,000 among which 6.7 cases are of women. Importantly, more
than 50% of women with Crohn's disease are under the age of 35 during diagnosis (Peery et al.,
2015). Particularly in UAE, a rise in 15% of cases has been witnessed since 2007 (Al-Hussaini et
al., 2016).
Crohn's disease
The disease is often linked with ulcerative colitis and inflammatory conditions small
intestine and large intestinal region. The complication is more severe in women due to the
changes in the hormonal level and thus causes irregularity in menstrual periods (Marrie et al.,
2017).
Hormonal changes during the lifespan of women
Particularly in women, the changes in hormonal levels and stress factor play a crucial role
as a trigger factor for Crohn's disease. The fluctuating level of estrogen and progesterone,
particularly act menopause, active menstruation phase, and woman taking birth control pills
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