Assignment on Discussion on Stem Cells

Running head: BIOLOGY
DISCUSSION ON STEM CELLS
Name of the Student
Name of the University
Author Note

BIOLOGY1
Table of Contents
Answer 1:...................................................................................................................................2
Answer 2:...................................................................................................................................2
Answer 3:...................................................................................................................................2
Answer 4:...................................................................................................................................3
References..................................................................................................................................4

BIOLOGY2
Answer 1:
Characterisation of immunologic myeloid progenitor cells has been found to provide a
new dimension for the separation and identification of stem cells, which are hemopoietic in
nature. HLA-DR determinants are the monoclonal antibodies that act against T lymphocytes
that are utilised to precisely define all the cell surface antigenic structure. HLA typing can be
used for stem cell characterisation (Hough et al., 2014). Immunocompatible stem cells can be
developed and characterized by using HLA typing. HLA matching is one of the major
disadvantages for the characterisation purpose. However, it provides a faster and efficient
way of developing and characterizing stem cells.
Answer 2:
Pluripotent stem cells have been found to display significant heterogeneity associated
with gene expressions. However, there is an inherent feature associated with the pluripotent
state, which is still not known. A minority subpopulation of cells has been found to display
high self-renewal capacity. According to Hough et al., (2014) their data supported the model
of an inherent and metastable self-renewing population which gives rise to the intermediate
cell population. The results have shown that heterogeneity inside a single-cell gene
expression system defines the subcellular populations. The expression of intercellular
signalling molecules has been found to identify a subpopulation associated with high
consistency expression system of pluripotency-associated genes priming without any lineage.
The final results indicate that heterogeneity can be inherent to the pluripotent cell which is
poised to the undergoing of the specification into the somatic and extra-embryonic lineage.
The authors found that self-renewal is strongly driven and the process of differentiation is
suppressed by the genetic and epigenetic factors. A difficulty has been found to be associated