Pathophysiology of Asthma: Bronchial Constriction, Inflammation, and Wheezing

Asthma
FOR VODCAST (THE ORAL PRESENTATION ASSIGNMENT)

Pathophysiology of asthma
 Bronchial smooth muscle contraction is the
condition in which bronchoconstriction
occurs in a quick span of time.
 This makes the airway narrow because of
the allergic reaction manifestation on
exposure to external stimuli and other
foreign particles or pollutants (Bonini &
Usmani, 2015).
 The allergen induced condition occurs due
to the IgE dependent mediators such as
histamine, tryptase, leukotriene, as well as
prostaglandins. Due to which, the smooth
muscle cells are contracted (Melen &
Pershagen, 2012).

Pathophysiology of asthma
 The mediators that increases the
allergic responses and creates
inflammation in the smooth muscle
cells, leads to inflammatory
bronchiole, especially its inner lining
(Rogala et al., 2012).
 This increases the swelling in this
layer and hence, the airway becomes
narrower. Due to which excess amount
of mucus is formed (Grotenboer et al.,
2013).