The provided assignment details a thorough examination of audit quality and assurance, incorporating multiple research papers and articles from esteemed sources. It delves into the significance of auditor responsibility, management accountability, and the importance of integrated reporting for enhanced transparency. The discussion also encompasses the role of academic boards in university quality assurance, external quality audits, and the impact on university quality improvement. Furthermore, it touches upon risk-based auditing, system validation for security compliance, and global harmonization in radiation therapy clinical trials. This comprehensive review provides a nuanced understanding of audit quality and assurance, highlighting key findings and implications from various research studies.