Drug Development Assignment for Multiple Drug Resistant Tuberculosis

Running head: BIOLOGICAL SCIENCES
DRUG DEVELOPMENT ASSIGNMENT
Name of the Student
Name of the University
Author note

1BIOLOGICAL SCIENCES
Bacterial Disease
Infection to Mycobacterium tuberculosis or MTB is one of the primary reasons for
morbidity and mortality for the people of low-middle income countries because of increased
resistance and hence, drug development against such resistance strains becomes one of the
primary sources using which such disease could be treated (Coll et al. 2015). Hence,
Tuberculosis, especially the multiple drug resistant tuberculosis (MDR-TB) will be chosen as the
disease for drug development assignment.
Source of Chemical Matter
To treat MDR-TB, the target for the antibiotic should be the central bacteria metabolism
system as this area of the drug discovery has very less amount of research and proposals. Success
achieved in targeting bacterial central metabolism would emerge as a big discovery for the drugs
associated to MDR-TB. Further, the chemical compound targeting the central metabolism of
bacteria would be able to deplete the non-fermentable carbon source so that it could not use the
non-fermentable carbon as the source. Therefore, this pathway will be chosen for this drug
discovery (Murima, McKinney and Pethe 2014).
Screening Approach
High throughput chemical screening process will be used in the screening process of
the new drug as it interacts with the bacterial influx system and it would be easier to
understand the effectiveness of the source used, to affect the bacterial metabolism system.
Therefore, this method of screen would be used to conduct the screening (Murima, McKinney
and Pethe 2014).