Boswelia for Rheumatoid Arthritis: Effectiveness and Recommendations

This presentation discusses the effectiveness of Boswelia in reducing inflammation and pain caused by rheumatoid arthritis. It includes a search strategy, inclusion and exclusion criteria, and a PRISMA flowchart. The presentation recommends using Boswelia as a natural medication for RA and provides dosage recommendations.

Boswelia for rheumatoid
arthritis

Table of Contents
INTRODUCTION
Aim
Objective
Background and Rationale
Method
Search strategy
Keyword used
MeSH search term
Inclusion and exclusion criteria
PRISMA Flowchart
Result discussion
Recommendation
REFERENCES

INTRODUCTION
Boswellia refers to a genus of trees which are known for their fragrant
resin. It is an effective anti-inflammatory which can be act as the painkiller
and can help in preventing the loss of cartilage (Levin and et. al., 2020).
This is the one which can be highly effective and can allow to get better
health impact on individual with any type of inflammation or pain. Arthritis
is a medical condition in which there is swelling along with tenderness of
one or more than one joints within older age people 50 above (Scherer and
et. al., 2020).

Aim
 To understand the effectiveness of Boswelia in rheumatoid arthritis.

Objective
 To analyse the causes and impact of rheumatoid arthritis.
 To determine the effectiveness of Boswelia in rheumatoid arthritis.

Background and Rationale
 According to Weyand and et. al., (2020), Boswellia is highly effective which
can help in reducing the inflammation and allow to lessen the RA. Boswellia
also known by Indian frankincense which is a resin herbal extract from the tree
of boswellia. This resins are used as the natural medicine practices which are
associated with using from different centuries (Kumar and et. al., 2019).
 It has high effectiveness on the inflammation and help to get removal of pain
through the body which are generally caused to the patient with rheumatoid
arthritis (Kumar Singh and et. al., 2021). Arthritis is mainly cause due to
inflammation in joints which are effective and can cause lead to cause pain
and get worsen with time. Here, Boswellia is the extract which is anti-
inflammatory in nature and have the ability to provide high effectiveness in
delivery of better response towards the pain and inflammation (Doaee and et.
al., 2019).

Method
 Search strategy
 Keyword used
 MeSH search term
 Inclusion and exclusion criteria
 PRISMA Flowchart

Search strategy
 The search strategy is defined as the aspect which is refers within the
research process for collection and selection of data and information. The
search strategy usually plays vital role in the collection of data or
information from the reliable and validated source which may include
website, books, journals and many more Singh and et. al., 2020). the major
search strategy which is used within the research process are PubMed,
Science direct, Springer Link and Medline Plus (Divisha and et. al., 2018).
These all are functional search strategy which have millions of article which
help to provide the reliable data and information which play vital role in the
relevance of information. The data and information which is gather with the
context that help to show the accuracy which is collected from the different
source are contain appropriate and reliable information which is valid and
show aspect that produce the context which is evidence based information
Kaur, 2021).

Keyword used
 Rheumatoid arthritis, arthritis, Boswelia in rheumatoid arthritis.

MeSH search term
 Boswelia in rheumatoid arthritis, effectiveness of boswelia in rheumatoid
arthritis,

Inclusion and exclusion criteria
 Inclusion criteria is defined as the characteristic or property which is
related with the prospective subject which must have if they are usually
show the aspect which is related with the included study Karlapudi and
et. al., 2018). It is also summarized with the simple term that the
inclusion contains those subjected which taken part in the research
process. whereas, the exclusion criteria are defined as those
characteristic that usually show the disqualification of prospective
subject form the inclusion in the study Pereira and et. al., 2021). It is
show aspect which is provide the information which is related with the
excluded part that is not considered with research study (Sancheti and
et. al., 2022).

Inclusion and Exclusion
Inclusion criteria Exclusion criteria
 English language is required.
 Randomised controlled trail taken
in the study.
 Older people are taken within the
study.
 The disease which is rated with
the joint pain are associated with
study and boswellia is considered
as natural resin for management
(Tabassum and Siddiqui, 2019).
 Rather than English is excluded from
the study.
 Cohort study and experimental study
is also excluded from the research
process.
 Children and adult are usually not
undertaking within the research
process.
 Allopathic drug and medication are
excluded from the context of study.

PRISMA Flowchart

Records identified from*:
Databases (n = 220)
Registers (n = 110)
Records removed before
screening:
Duplicate records removed (n =
65)
Records marked as ineligible by
automation tools (n = 30)
Records removed for other
reasons (n = 10)
Records screened
(n = 180)
Records excluded**
(n = 30)
Reports sought for retrieval
(n = 110)
Reports not retrieved
(n = 65)
Reports assessed for eligibility
(n = 90) Reports excluded:
Reason 1 (n = 50)
Reason 2 (n = 25)
Reason 3 (n = 10)
etc.
Studies included in review
(n = 45)
Reports of included studies
(n = 45)
Identification of studies via databases and registers
Identification
Screening
Include
d

Result discussion
 There are large number of population who are facing high difficulty due to
getting infected from the RA. It includes the inflammation and cause the within
joint and create pain. This can have high impact on the older people where
they need better and effective medication which can be helpful in getting
better response and relief from the pain and inflammation. Here, Boswellia is
highly effective and can lead to create high impact on the delivery of better
and effective response towards the health improvement for the older age
people over 50. Here, it has been find that due to having anti-inflammatory
property and pain killer effect, it allows to get better and effective response
towards the delivery of better health benefits. There is also need to ensure
about the use of natural medication which are getting use from the effective
response for the RA patient. Through using the research, it can allow to collect
the information about the effectiveness of learning through different studies
which implies about the effectiveness of getting better response toward the
delivery of better health form getting impact on patient with RA. It can allow to
get better relief from the pain and inflammation which are caused due to RA.

Recommendation
 There is need to use the Boswellia which an effective resin that can be
used to reduce the impact of pain and inflammation which are caused
due to RA. Here, Boswellia can be effective when it taken three time a
day with 300 to 400 milligrams orally. It is recommended to use the
Boswellia extract which can used safety with dose less than 1000mg for
up to 6 months.
 It is also recommended to use the intake of Boswellia which can be
effective and allow to get better response towards the delivery of
getting better positive impact on the older people over 50. It effective
can be observed after 4 week of continuous dose within limits. There
can also be some risk which are associated with taking care of patient
needs and their dose with better impact.

REFERENCES
 Divisha and et. al., 2018. Modulation of Oxidative Stress Mediators in Adjuvant
Induced Arthritis by Herbal Adaptogen Boswellia serrata. Toxicology International
(Formerly Indian Journal of Toxicology), 25(4), pp.193-197.
 Doaee and et. al., 2019. Effects of Boswellia serrata resin extract on motor dysfunction
and brain oxidative stress in an experimental model of Parkinson’s disease. Avicenna
journal of phytomedicine, 9(3), p.281.
 Erusappan and et. al., 2021. Investigation of Alpinia calcarata constituent interactions
with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and
network approach. Journal of Molecular Modeling, 27(1), pp.1-14.
 Gaikwad and et. al., 2019. Formulation and evaluation of Boswellia serrata resin gel by
using different gelling agents. International Journal of Bio-Pharma Research, 8(8),
pp.2763-2768.
 Gomaa and et. al., 2021. Boswellic acids/Boswellia serrata extract as a potential
COVID-19 therapeutic agent in the elderly. Inflammopharmacology, 29(4), pp.1033-
1048.
 Kumar and et. al., 2019. Effect of Boswellia serrata extract on acute inflammatory
parameters and tumor necrosis factor-α in complete Freund's adjuvant-induced animal
model of rheumatoid arthritis. International Journal of Applied and Basic Medical
Research, 9(2), p.100.
 Levin and et. al., 2020. Assessing the age specificity of infection fatality rates for
COVID-19: systematic review, meta-analysis, and public policy implications. European
journal of epidemiology, 35(12), pp.1123-1138.
 Pannu and et. al., 2019. Therapeutic Potential of Thymoquinone in Treatment of
Rheumatoid Arthritis and Related Autoimmune Diseases. In Bioactive Food as Dietary
Interventions for Arthritis and Related Inflammatory Diseases (pp. 575-587). Academic
Press.
 Sancheti and et. al., 2022. Herbs Used In Treatment of Arthritis: A Review. International
Journal of Chemical and Lifesciences, 11(2), pp.2332-2340.
 Scherer and et. al., 2020. The etiology of rheumatoid arthritis. Journal of
autoimmunity, 110, p.102400.
 Tabassum, K. and Siddiqui, A., 2019. Kundur (Boswellia serrata Roxb)-A boon of nature in
the world of Unani system of medicine. International Journal for Advance Research and
Development, 4(2), pp.10-14. Kaushik, S., Roy, A., Purabiya, P. and Satapathy, T., 2020. Anti
Bacterial and In Vitro Anti-inflammatory Potential of Boswellia seratta: A Potent Bioactive
Compound. Research Journal of Pharmacy and Technology, 13(3), pp.1079-1082.
 Wang and et. al., 2021. Traditional herbal medicine: Therapeutic potential in rheumatoid
arthritis. Journal of ethnopharmacology, 279, p.114368.
 Weyand and et. al., 2020. Immunometabolism in the development of rheumatoid
arthritis. Immunological reviews, 294(1), pp.177-187.
 Ytterberg and et. al., 2022. Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid
Arthritis. New England Journal of Medicine, 386(4), pp.316-326.

 Kumar Singh and et. al., 2021. RHEUMATOID ARTHRITIS AND GOUT: MEDICINAL PLANTS AS
A DRUG ALTERNATIVE. Journal of Advanced Scientific Research, 12.
 Ayub and et. al., 2018. Biological activity of Boswellia serrata Roxb. oleo gum resin
essential oil: effects of extraction by supercritical carbon dioxide and traditional
methods. International Journal of Food Properties, 21(1), pp.808-820.
 Mirza and et. al., 2021. Osteoarthritis in Dogs—Effect of Diet.
 Kaur, 2021. Rheumatoid arthritis: Pathophysiology, treatment and improved efficacy of
targeted treatment using novel herbal therapeutics formulations. International Journal of
Green Pharmacy, 15(3).
 Singh and et. al., 2020. Medicinal plants used against various inflammatory biomarkers for
the management of rheumatoid arthritis. Journal of Pharmacy and Pharmacology, 72(10),
pp.1306-1327.
 Karlapudi and et. al., 2018. A placebo-controlled double-blind study demonstrates the
clinical efficacy of a novel herbal formulation for relieving joint discomfort in human
subjects with osteoarthritis of knee. Journal of medicinal food, 21(5), pp.511-520.
 Pereira and et. al., 2021. Pharmacological Modulators of Autophagy as a Potential Strategy
for the Treatment of COVID-19. International journal of molecular sciences, 22(8), p.4067.