This article critically discusses the possible role of the Mesotelencephalic Dopamine System in addiction. It explores the components of this system, such as the nigrostriatal, mesolimbic, and mesocortical pathways, and their involvement in regulating incentive salience, motivation, and fear. The article also examines the mesolimbic pathway's connection to the development of rewarding effects of drugs and its association with addiction. Additionally, it discusses the role of dopamine as a neurotransmitter in the addiction pathway and its impact on behavior and reward processing.