Calcium Channel Blockers and Anti-Coagulant

Running head: CALCIUM CHANNEL BLOCKERS AND ANTI-COAGULANT 1
Calcium Channel Blockers and Anti-Coagulant
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CALCIUM CHANNEL BLOCKERS AND ANTI-COAGULANT 2
1. Calcium channel blockers (calcium antagonists)
Body System:
Drug
Classification
Drug
Examples
Mechanism of action
“What will it do to
me? (benefit)
Indications for
use “What is the
drug for?”
Adverse effects
“What might it do to
me? (risks)”
Key
Contraindication
s & Drug-drug
interactions
Special consideration
(administration times
monitoring
therapeutic effects)
Calcium channel
blocking agents
(dihydropyridines
)
Amlodipine
Diltiazem
Felodipine
Isradipine
Nicardipine
Nifedipine
The drug works
through relaxation and
vasodilation of the
blood vessels, which
improves the oxygen
supply and lowering
the blood pressure
(Bladen, Gündüz,
Şimşek, Şafak &
Zamponi, 2014).
By lowering the blood
pressure, the drugs
relieve chest pain
(Angina) and control
The drugs work
by restricting the
amount of
calcium entering
the cardiac and
smooth muscle
cells by blocking
voltage-gated
calcium
channels.
Calcium channel
blockers are
mainly used to in
the treatment of
The drug has various
side effects including
constipation, nausea,
drowsiness, low blood
pressure and Sexual
dysfunction
(Godfraind, 2014).
The drugs are
contraindicated in
individuals with
known
hypersensitivity to
the medication or
its component.
Some drugs
examples in this
category have
many listed drug
interactions; for
instance,
Amlodipine has
A patient using the
drug should be
monitored keenly.
Checking for
symptoms
improvement or
maintenance of blood
pressure is essential to
determine
efficacy(Godfraind,
2014). The medication
are titrated quickly;
hence, patient
assessment should be

CALCIUM CHANNEL BLOCKERS AND ANTI-COAGULANT 3
irregular heartbeat. hypertension.
The drugs work
by slowing the
movement
of calcium into
the heart cells of
and walls of the
blood vessel,
making it easy
for the heart to
pump blood and
widens
the blood vessels.
Hence the heart
does not struggle
to pump blood,
and the blood
pressure is
lowered
600 registered
interactions
(Graudins, Lee &
Druda, 2016).
Patients should
avoid grapefruit
juice as some of
the drugs in this
category interacts
with the juice and
can have an
adverse impact of
blood pressure and
heart rate.
done regularly.