Non Hormonal Cancer: Triple Negative Breast Cancer

Cancer
(Non
hormonal)
NAME OF THE STUDENT:
NAME OF THE UNIVERSITY:

Introduction
▪ Non hormonal cancer is not fueled by
hormones like estrogen and
progesterone.
▪ There is no role of the HER protein in
cancer.
▪ The most common type of non hormonal
cancer is triple negative breast cancer.
▪ Almost 10-20 % of the cancers are triple
negative breast cancers (Gross et al.,
2014).

General Physiology
Estrog
en
Proges
terone
Hormo
ne
Epider
mal
Growth
Factor

Homeostasis and Energy Balance
▪ Increased leptin levels and decreased
levels of adinopectin lead to an
imbalance in homeostatsis.
▪ The LPIN1 gene encoding lipin-1 is a
phosphatic acid phosphatase which
plays a role in energy balance through
the disruption of the phosphate bonds.
Regulation of Lipin-1 helps in the
maintainance of endoplasmic reticulum
homeostasis (Fan et al., 2015).