This assignment involves a systematic review and meta-analysis of transitional care interventions to prevent readmissions for persons with heart failure. It also covers top ten risk factors for morbidity and mortality in patients with chronic systolic heart failure and elevated heart rate, as well as guidelines for the management of patients with atrial fibrillation. The assignment includes recommendations on pre-hospital and early hospital management of acute heart failure, determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure, and effectiveness of a nurse-led home-based heart failure management program.