Assignment On Challenge into Body Integrity.

Running head: CHALLENGE INTO BODY INTEGRITY 1
Challenge into Body Integrity
Name
Institutional Affiliation

CHALLENGE INTO BODY INTEGRITY 2
1. Pathophysiology
Mr. David has localized chronic lower back pain from somatic nociceptive activity that
originates from thoracic and lumbar spine caused by internal damage. The vertebral lesions
affect the molecular pain mediators like chemokines, protons, neurotrophins and ATP (Finucane,
2013). The multimodal messaging takes place through chemical or molecular of pain as part of
the nociception neural endings innervating periosteum via spinal dorsal horn neurons, which is
activated by stimuli to a bone (Finucane, 2013).
The metastatic lesions might develop through tumour cells alongside bone interacting via
a process like embolization and vascularization that disrupt normal repair of skeletal (Aielli,
Ponzetti & Rucci, 2019). Nociceptors in the spinal areas before the differing MRI outcome might
have had a causal reason of the degenerated disc, lesions, inflammation, or mechanical injury
arising from the benign aneurysmal bone cysts or ABCs (Finucane, 2013).
Using NSAIDs supports reduction of pain with safe therapeutic use in elderly population.
Minimal, but consistent relief of symptoms remains feasible with intervention of up to 3-months
in mild to moderate reported pain. Variances to psychology rises with increase in age, hence
adverse effects (AE) with NSAIDs utilization surges (Enthroven, Roelofs, & Koes, 2017).
Elderly population need individualized treatment planning, accounting for
gastrointestinal (GE) tolerability, surged probability of polypharmacy/contraindications and
reduced adaptive motility, blood movement, secretions, and surface degradation when NSAIDs
is being prescribed. Adverse effects like GE bleeds, cardiac and respiratory distress and toxic
buildup linked to NSAIDs might counter gains of proven pain reduction effectiveness.
2. Analgesics