This document discusses the pathogenesis of acute exacerbation of chronic systolic heart failure, nursing strategies to manage the condition, and the mechanism of action of IV furosemide and sublingual glyceryl trinitrate. It explains the causes of chronic systolic heart failure, the pathophysiology of heart failure, and the two main compensatory mechanisms that activate the sympathetic nervous system and renin-angiotensin-aldosterone system. It also suggests two high priority nursing strategies to manage the condition, which include administering oxygen therapy and effective medication, and maintaining the pattern of heart rate. Finally, it explains the mechanism of action of IV furosemide and sublingual glyceryl trinitrate.