A clinical decision support system (CDSS) is a crucial tool for making informed decisions in healthcare. It consists of three main components: data repository, rules engine, and interface. The data repository stores structured data to provide relevant information on drug-related topics. The rules engine helps develop and manage information, providing insights into various clinical contexts. The interface connects patients with healthcare professionals, enabling them to access the CDSS. This system has several benefits, including improving patient safety, reducing medication errors, and decreasing misdiagnosis. Additionally, it enables healthcare professionals to assess all relevant information for a particular area. To implement an effective CDSS, standards and regulations must be followed, such as the Food and Drug Safety Act of 2012 and the American Recovery and Reinvestment Act of 2009.