Clinical Epidemiology Assessment

Clinical Epidemiology Assessment
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Question 1
a. What is effect of Liraglutide, a glucagon-like peptide-1 analogue compared top other
medication regimes on weight change among type II diabetes adults over time?
b. PICO elements in the research question
Population : Type II diabetes adults
Intervention : Liraglutide, a glucagon-like peptide-1 analogue
Comparison : Other type II diabetes
Outcome : weight reduction
Time : Medication period
Question 2
a. What are the risk factors associated to multi drug tuberculosis resistances among the
migrant populations after regular tuberculosis management?
b. PICO elements in the research question
Population : Migrant Populations
Intervention : Risk factors
Comparison : Other type II diabetes
Outcome : multi drug tuberculosis resistances
Time : -
Question 3
I : b
II : a
III : a
IV : a
V : e
VI : a
VII : d

Question 4
What is the effect of Liraglutide, a glucagon-like peptide-1 analogue compared to other
medication regimes on weight change among type II diabetes adults over time?
a. Search strategy
The key objective of this study is to assess and find out literature studies undertaken on the
effect of Liraglutide, a glucagon-like peptide-1 analogue on weight status of type II diabetes
patients. Eligible trials for this study were identified through electronic database searches.
Electronic searches were undertaken using pub med and screen articles undertaken in the last
8 years. The search terms entailed Liraglutide, a glucagon-like peptide-1 analogue, weight
and type II diabetes. Usage of Boolean operators will be used interchangeably in the study
such as AND and OR to search the relationship between usage of Liraglutide, a glucagon-like
peptide-1 analogue and weight changes. More specifically “liraglutide”, “glucagon-like
peptide-1”, or “exenatide” were used. Further to narrow down on the design. Pubmed search
database searched studies done between 2015 and 2019. The results obtained yielded 15
searches.
b. Study designs suitable
The inclusion criteria for the study designs suitable for this search will; be published human
studies undertaken as randomised placebo, parallel controlled trials and clinical trails
undertaken. The phrase was used “glucagon-like peptide-1”, “liraglutide”, or “exenatide” and
type II diabetes; and “Randomised Controlled Trial” or “random” so as to fir the key design
being sought in the literature search.
c. Best article found
Santilli, F., Simeone, P. G., Guagnano, M. T., Leo, M., Maccarone, M. T., Di Castelnuovo,
A., ... & Cianfarani, S. (2017). Effects of liraglutide on weight loss, fat distribution,
and β-cell function in obese subjects with prediabetes or early type 2 diabetes.
Diabetes Care, 40(11), 1556-1564.