1CLINICAL REASONING CASE STUDY Question 1) Asthma pathophysiology is dynamic and includes airway irritation, occasional ventilation blocking, and bronchial hyper responsiveness(Sullivan et al., 2016). Inflammatory response serves asa key function in the pathophysiology of asthma. Airway inflammation includes the association of several cell types and several mediators with airways that ultimately result in the hallmarkpathophysiologicalfeatures(Baiardinietal.,2015)ofthedisease:bronchial inflammation and airflow restriction that result in repeated symptoms of cough, wheeze and shortness of breath. Allergic reactions remain critical among all social influences(Shams & Epstein, 2019). As described in the case study, Frances says that she had a terrible asthma as a child, but she's been much improved in the last few years. In fact, the new asthmatic condition intensified with the inclusion of their cats in her friend's room. The cats' hair may be one of the allergensresponsible for causing her asthma. The cause of airway inflammation in asthma can be acute, subacute, or persistent, and the involvement of airway oedema and mucus production can also lead to airflow congestion and bronchial reactivity. Question 2) a) The two risks with asthma that Frances may experience involve her being faced with chronic issues affecting her lungs, like pneumonia(Torres et al, 2015)and becoming exhausted, which could result in her under-performance or loss of function. It may contribute to psychiatric issues, including tension, anxiety, and depression. b) Asthma doesn't quite cause pneumonia directly, although patients with recurrent lung conditionsaremorepronetoexperiencepneumoniaduetopriorpulmonarydiseaseor weakening of lung tissue. Of the same cause, a person with asthma can have more serious effects and risks with colds and flu.Numerous studies indicate that inhaled corticosteroids(Bansal et al., 2015), which serve as the primary treatment choice for asthma, may raise the risk of contracting pneumonia or other respiratory infections. Typical asthma flare-ups include hacking,
2CLINICAL REASONING CASE STUDY wheezing and a sense of tightness in the lungs. Decreased lung activity results in trouble breathing and elevated heartbeat. The wheezing may be high-pitched and whistling. While asthma has no remedy, symptoms appear to react well to medication and effective therapies. When microbes or viruses multiply inside the lung tissue, the body's innate immune defenses tend to fill the lungs with mucus(Torres et al., 2015). It makes breathing more difficult and leads a person to cough. The mucus enters the airways that constrict in reaction to infection, creating a loss of oxygen flow in the body. As a consequence, the muscles continue to expend additional energy, which may cause chest pressure worse. Question 3) a) Studies have projectedthat salbutamol(Ullmann, Caggiano &Cutrera, 2015)has a fair and equitable effect on beta2-adrenergic receptors particularly in comparison to isoproterenol. While beta2-adrenoceptors seem to be the prevalent adrenergic receptors in the bronchial smooth muscle and beta1 adrenoceptors are the prominent receptors in the heart, beta2-adrenoceptors in the humanheartare about10% to 50% of theoverallbeta-adrenoceptors.The specific mechanism(Zhou et al., 2017)of these receptors has not been identified, but their existence gives rise to the likelihood that even selective beta2-agonists can have cardiac consequences. Regulation of beta2-adrenergic receptors on the smooth muscle of the airway contributes to the development of adenyl cyclase and an rise in the intracellular concentration of cyclic-3′,5′- adenosinemonophosphate(cyclicAMP).Salbutamolrelievestherelaxedtissuesofboth airways, from trachea to terminal bronchioles.This rise in cyclic AMP contributes to the activation of protein kinase A, which also prevents myosin phosphorylation and reduces intracellular ionic calcium concentrations, culminating in stabilization. b) Anxiety and palpitation are the most frequent side effects(Baiardini et al., 2015) associated with salbutamol. c) With side effects, Frances can feel anxious or nervous along the way and experience an irregular heart rate. The primary duty of the nurses will be to test(Cabilan & Boyde, 2017)and
3CLINICAL REASONING CASE STUDY validate the order of the doctor. Secondly, there is a need to uphold the freedoms in the administration of drugs, such as providing the correct drug to the correct individual and trying to use the best path and at the right moment. Surveilling the vital stats of the patient as well as the serum electrolytes, ECG and thyroid function test results need to be monitored and prescribing the drug correctly must be achieved, because adverse reactions and tolerances that occur with any administration(de Sousa et al., 2015). The side rails must be lifted as the patient can feel anxious and drowsy due to this medication. In fact, it will be ensured that the space is well illuminated and that the individual has a person next to them in the event of vertiges. This should be monitored to determine the pulse for pacing and to include oral treatment. Eventually, upon inhalation, the patient must gurgle to get rid of the uncomfortable aftertaste of the inhalation. Nurses may need to auscultate the lungs for the occurrence of adventitious breathing noises that may signify pulmonary edema, airway obstruction or bronchospasm.In fact, the person will be checked in a certain relaxation role to promote optimal rest and sleep. Question 4) The nurses will track critical data and determine France's respiratory condition by tracking the extent of signs, as well as by observing the rhythm of coughing and wheezing. Nurses will track critical data and determine France's respiratory condition by tracking the extent of signs, as well as by observing the rhythm of coughing and wheezing(de Sousa et al., 2015). It is important to determine the respiratory condition of the patient by evaluating the extent of the symptoms. In fact, the description of the medications that Frances is actually consuming and prescribing as indicated. Frances need to be continuedto be checked onfor reactions to such drugs, so an antibiotic might be used if the patient has an ongoing respiratory infection. Question 5) Wheezing(Shimodaetal.,2017)canresultfromconcentratedordiffuseairway restriction or congestion from either the larynx level to the small bronchi. Airway restriction can be induced by bronchoconstriction, mucosal edema, exterior compression, or partial blocking of the tumor, foreign body, or tenacious secretions. Oscillations or movements of nearly closed airway walls are assumed to induce wheezes. Air flowing through a compressed part of the
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4CLINICAL REASONING CASE STUDY airway at high velocity induces a reduction in gas pressure and flow in the constricted region. By the end of the day, the internal airway pressure starts to rise and scarcely reopens the airway lumen. Question 6) Studies have shown that sensitivity to pet dander may trigger symptoms of asthma in people with asthma, but pets and dander do not trigger asthma to grow(Farrokhi et al., 2015). Frances has been known to have asthma, which indicates that she is vulnerable to periods of airway narrowing (bronchoconstriction) or acute airway spasm (bronchospasm) due to a number of causes. Animal Dander or fur extracts produce endotoxin, which is a compound that induces a negative physical reaction. These endotoxins stimulate the immune cells and proteins, especially IgE.Thereby,forthosewhohaveasthma,theinflammatoryreactionconsistsin bronchoconstriction or bronchospasm, which can be a cause in Frances. Question 7) The three high priority nursing problems can be considered as firstly the ineffective breathing pattern(Borge et al., 2015)of Frances that can be triggered by swelling and spasm of thebronchialtubesinreactiontoinhaledirritants,pathogens,medications,allergiesor pathogens. Secondly, inadequate airway clearing(Chaves et al., 2016)can be regarded as anotherproblemwhereFranceshasbeenshowntobeunabletoremovesecretionsor obstructions from the respiratory tract in order to preserve a remove airway. Thirdly, the lack of awareness or contextual details(Mammen et al., 2018)on France's asthma could be one of the main challenges. Question 8) Nurses need Frances to recognize and teach her about the asthma symptoms that will make her mindful of them and make her capable of managing those(Mammen et al., 2018). Having Frances think about the proper usage of spacers through long, deep inhalation and relaxing during inhalation can insure the effectiveness of the drug. This should be made clear to Frances that the excessive application of MDI would result in medicines not going far enough to
5CLINICAL REASONING CASE STUDY reach the airway. Assessing respiratory patterns and adventitious noises such as wheezes and stridor is believed to be one of the key strategies to be sought in the case of an inadequate breathing pattern. Question 9) In order to prevent potential asthma attacks, informing Frances on the causes and specifics of asthma is quite necessary(Leung et al., 2015). Frances should be educated to learn how to treat treatment will save time coupled with knowledge about what has been successful in the past decides the correct action required. A fallacy of an asthma attack is that it can be treated withoutmedicationsbyself-controlandtraining.Knowledgeinasthmaself-management (MacLeodetal.,2018)eliminatestheneedforrepeatedhospitalizations.Realizingand recognizing allergen regulation, preventing pollution control, eliminating chemical contaminants such as perfumes, aerosol sprays, powders, precipitators, and dietary practices may help deter asthma attacks from happening. Question 10) a) The two indicators of progress of France's situation are, first, the preservation of an optimal breathing routine, as indicated by balanced breathing, regular respiratory rate or rhythm, and the lack of dyspnea, and, second, the preservation of the airway system as illustrated by consistent breathing patterns, increased oxygen circulation, usual pace and duration of breathing, and the capacity to cough efficiently. b) The following outcomes can be predicted by urging Frances to perform deep breathing and coughing exercises. It tends to remove and also expectorate residual secretions and add to the successful clearance of mucus from the lungs. In fact, nurses will insure that Frances gets as much downtime as practicable(Chaves et al., 2016). Fatigue is reported to be normal of intensified breathing activity from an inadequatebreathing method. Movement raisesthe
6CLINICAL REASONING CASE STUDY metabolic rate and demands for oxygen. Controlling the physical resistance will help her strengthen her health. Question 11) Anxiety is most often seen in asthma, and when focusing on Frances' treatment, nurses will remain with her and help her to exercise steady, deep breathing. In addition, to remind Frances and her important closed ones of regular supervision that will guarantee timely intervention. The involvement of a trustworthy individual(Sweeney et al., 2016)may offer her a sense of protection. In addition, promoting the use of relaxation strategies such as progressive muscle relaxation, diaphragm and bagged lip breathing that help her relax as a study project that relaxation techniques are one of the most successful ways to relieve anxiety in patients.
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7CLINICAL REASONING CASE STUDY References: Aderogba, A. I., Ladipo, M. M. A., & Ige, O. M. (2016). Assessment of knowledge and attitude of adult asthmatics towards asthma and impact of family support on adherence to the use of inhalers.Afr. J. Med. med. Sci,45, 349-355. Alotaibi, H. S., Shivanandappa, T. B., & Nagarethinam, S. (2016). Contribution of community pharmacists in educating the asthma patients.Saudi Pharmaceutical Journal,24(6), 685- 688.doi.org/10.1016/j.jsps.2015.06.002 Baiardini, I., Sicuro, F., Balbi, F., Canonica, G. W., & Braido, F. (2015). Psychological aspects in asthma: do psychological factors affect asthma management?.Asthma research and practice,1(1), 7. doi.org/10.1186/s40733-015-0007-1 Bansal, V., Mangi, M. A., Johnson, M. M., & Festic, E. (2015). Inhaled corticosteroids and incident pneumonia in patients with asthma: Systematic review and meta-analysis.Acta medica academica,44(2), 135DOI: 10.5644/ama2006-124.141. Borge, C. R., Mengshoel, A. M., Omenaas, E., Moum, T., Ekman, I., Lein, M. P., ... & Wahl, A. K. (2015). Effects of guided deep breathing on breathlessness and the breathing pattern in chronic obstructive pulmonary disease: A double-blind randomized control study.Patient education and counseling,98(2), 182-190.doi.org/10.1016/j.pec.2014.10.017 Cabilan, C. J., & Boyde, M. (2017). A systematic review of the impact of nurse-initiated medicationsintheemergencydepartment.AustralasianEmergencyNursing Journal,20(2), 53-62.doi.org/10.1016/j.aenj.2017.04.001 Chaves, D. B. R., Beltrão, B. A., Pascoal, L. M., de Souza Oliveira, A. R., Andrade, L. Z. C., dos Santos, A. C. B., ... & da Silva, V. M. (2016). Defining characteristics of the nursing diagnosis “ineffective airway clearance”.Revista Brasileira de Enfermagem,69(1), 92- 98.DOI:http://dx.doi.org/10.1590/0034-7167.2016690114i Cipriani, F., Calamelli, E., & Ricci, G. (2017). Allergen avoidance in allergic asthma.Frontiers in pediatrics,5, 103.doi.org/10.3389/fped.2017.00103 Clark, V. L., Gibson, P. G., Genn, G., Hiles, S. A., Pavord, I. D., & McDonald, V. M. (2017). Multidimensionalassessmentofsevereasthma:asystematicreviewandmeta‐ analysis.Respirology,22(7), 1262-1275.doi.org/10.1111/resp.13134
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9CLINICAL REASONING CASE STUDY Patel, P. H., & Sharma, S. (2019). Wheezing. InStatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482454/. Prado, P. R. D., Bettencourt, A. R. D. C., & Lopes, J. D. L. (2019). Defining characteristics and relatedfactorsofthenursingdiagnosisforineffectivebreathingpattern.Revista brasileira de enfermagem,72(1), 221-230.doi.org/10.1590/0034-7167-2018-0061. Radhakrishna, N., Tay, T. R., Hore-Lacy, F., Hoy, R., Dabscheck, E., & Hew, M. (2016). Profile of difficult to treat asthma patients referred for systematic assessment.Respiratory medicine,117, 166-173.doi.org/10.1016/j.rmed.2016.06.012 Shams, M. R., & Epstein, T. E. (2019). Controlling Triggers for Asthma in Older Adults: Environmental Allergens, Indoor and Outdoor Air Pollutants, and Infection. InTreatment of Asthma in Older Adults(pp. 119-134). Springer, Cham.doi.org/10.1007/978-3-030- 20554-6_11 Shimoda, T., Obase, Y., Nagasaka, Y., Nakano, H., Kishikawa, R., & Iwanaga, T. (2017). Lung soundanalysiscanbeanindexofthecontrolofbronchialasthma.Allergology International,66(1), 64-69.oi.org/10.1016/j.alit.2016.05.002 Sullivan, A., Hunt, E., MacSharry, J., & Murphy, D. M. (2016). The microbiome and the pathophysiology of asthma.Respiratory research,17(1), 163.doi.org/10.1186/s12931- 016-0479-4 Sweeney, J., Patterson, C. C., Menzies-Gow, A., Niven, R. M., Mansur, A. H., Bucknall, C., ... & Heaney, L. G. (2016). Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the BritishThoracicDifficultAsthmaRegistry.Thorax,71(4),339-346. doi.org/10.1136/thoraxjnl-2015-207630 Torres, A., Blasi, F., Dartois, N., & Akova, M. (2015). Which individuals are at increased risk of pneumococcal disease and why? Impact of COPD, asthma, smoking, diabetes, and/or chronic heart disease on community-acquired pneumonia and invasive pneumococcal disease.Thorax,70(10), 984-989.doi.org/10.1136/thoraxjnl-2015-206780 Ullmann, N., Caggiano, S., & Cutrera, R. (2015, December). Salbutamol and around. InItalian journal of pediatrics(Vol. 41, No. 2, p. A74). BioMed Central. doi.org/10.1186/1824- 7288-41-S2-A74
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10CLINICAL REASONING CASE STUDY Uwaoma, C., & Mansingh, G. (2015, January). Towards real-time monitoring and detection of asthma symptoms on resource-constraint mobile device. In2015 12th Annual IEEE Consumer Communications and Networking Conference (CCNC)(pp. 47-52). IEEE. DOI:10.1109/CCNC.2015.7157945 Zhou, L., Wang, Q., Zhang, Y., Ji, Y., & Yang, X. (2017). Aquatic photolysis of β2-agonist salbutamol:kineticsandmechanismstudies.EnvironmentalScienceandPollution Research,24(6), 5544-5553.doi.org/10.1007/s11356-016-8207-7