Clinical Treatment of Rheumatoid Arthritis

Running head: CLINICAL TREATMENT OF Rheumatoid Arthritis
Clinical Treatment of Rheumatoid Arthritis
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1CLINICAL TREATMENT OF RHEUMATOID ARTHRITIS
Introduction:
Rheumatoid Arthritis (RA) is a form of autoimmune disease where the patient’s
immunological cells fail to distinguish between self-cells and antigens and attack body tissues.
This condition causes inflammation in the joints of the body leading to stress and pain followed
by swelling. The case study provided shows a similar situation where the patient fails to feel any
better even after prescription of analgesics. The disease may also spread to other parts of the
body in severe conditions (Furst & Emery, 2014). The patient that needs to be analyzed is
informed to have a history of RA and is currently undergoing pain even after regular dose of
Motrin 400 mg and occasional dose of Acetylsalicylic Acid or ASA.
Discussion:
The patient is shows the clinical symptoms of RA, that involve swelling of joints due to
inflammation causing pain. Severe progression of the disease may lead to stiffness and lack of
movement in the area. In some cases, the disease becomes a chronic inflammatory condition,
which can permanently destroy joint tissues and cause joint deformity (Arcangelo, Peterson,
Wilbur & Reinhold, 2017). The usual clinical trials include commencement of Non-steroidal
Anti-inflammatory drugs or NSAIDs (Lindhardsen et al., 2013) as well as disease-modifying
anti- rheumatic drugs or DMARDs.
Analysis of the medical history of the patient in the question reveals that he or she is
prescribed, Motrin 400 mg which is a common drug administered to patients suffering from RA.
This particular medicine is a brand name of Ibuprofen type of drugs (Kasper 2015). It is known
variant of NSAID to stop pain dental, menstrual, headaches as well as arthritic pain. The working

2CLINICAL TREATMENT OF RHEUMATOID ARTHRITIS
mechanism of Ibuprofen is not clearly known, but it suggested that Ibuprofen blocks the action
of an enzyme called cyclo-oxygenase or COX, which is essential for the synthesis of
prostaglandins through the arachidonic acid pathway (Echizen et al., 2018). Prostaglandins are
the chemicals responsible for the pain sensation in the body. Inhibition the COX enzymes ensure
the decrease of the lowered levels of prostaglandin.
The patient in question was also previously prescribed to take ASA occasionally for the
lowering of pain caused by the inflammation. Acetylsalicylic Acid or ASA is another drug that is
administered in patients with RA and also other general painful medical conditions. It is an
established analgesic that regularly prescribed for pain, fever and headache, also in some cases
lowers the risk of fatality due to heart failures when given in low doses (Crofford, 2013).
Recommendation:
Analyzing the patient’s clinical history and evaluating the current condition, it can be
deduced that the patient is not showing signs of improvement which means the disease has
significantly progressed and right now alternative drugs, like Disease modifying Anti-rheumatic
Drugs (DMARD) and Biologics need to be administered which will slower the disease
progression. Progression of the diseases needs to be stopped to inhibit tissue injury and
permanent damage (Furst & Emery, 2014).
DMARD are implemented to patients with RA that effectively slow down the progression
of the disease. There are many variants of this drug whose mechanism of action differs from one
another. Traditionally these modifying drugs suppress the immunity of the patient by blocking
the inflammation in the affected areas. Some other variants of these drugs block specific
pathways of the body which alter the signaling cascade inside the immune cells. Biological