1BIOETHICS Introduction: Bioethics is the analysis of the traditionally divisive ethics brought on by biological and scientific advancements. When it applies to medical procedure, practice and science, it is often spiritual discernment. The paper below analyses autonomy and the limits to autonomy(Dive & Newson, 2018)in relation to issues relating to normal and pathological. Additionally, the paper also reviews the principal of autonomy and the reason of their being in conflict with the principle of beneficence along with the presentation of arguments on why the slippery slope can be a persuasive argument in bioethics and critically discuss its use in debates about euthanasia and genetic revolution. Lastly, the technological imperative is explained in a detailed manner using as examples the issue of xenotransplantation(Sautermeister, Mathieu & Bogner, 2015)and issue of severely impaired newborns. Discussion: ‘’One person’s abnormality is another person’s life”: Normality is a behavior that may be expected for an entity (intrapersonal normality) because it is compatible with the person's more typical behavior. Common is often used to characterize human actions that are compatible with the most prevalent behavior of culture (called conformity). Normality meanings differ by person, period, place, and circumstance, which continue to shift along with evolving social expectations and norms. Normality is seen as nice at its simplistic form while abnormality is seen as poor(Roskies, 2019). Many human actions would fit what is considered the standard curve. Looking at a bell-shaped curve, several people are grouped near the top of the curve, defined as the average. Individuals that fall too
2BIOETHICS much at either end of the average continuum may be deemed "extreme." It's necessary to remember that the differences between average and extreme are not associated with good or poor. An individual who fell at the very top end of the curve would suit within our peculiar definition; that individual would also be called a genius. Clearly this is a situation where it is potentially a positive idea to be outside of the standards. Amongalltheskepticismleveragedoverthecomplexitiesofthecycleof institutionalizing and socializing medication, findings show the need to examine the basic definitions of safety and disease. Thus, analyzes on topics such as wellness, illness, existence, autonomy remain important in our profession, while-or perhaps, since-in biomedicine, medical science is still essential and deemed impartial and objective; therefore, the social and cultural aspects that are also present in the therapeutic process are often ignored.(Blasimme & Vayena, 2016) states in his paper about thedifferent characteristics of autonomy that are often not mutually reinforcing on each other; there might be patients with problems in one dimension, while in others being fully autonomous. One of such evidence offered, is that of psoriasis, a progressive skin condition with an exceedingly weak record of commitment. Since there are several potential reasons for non-adherence in patients with psoriasis, evaluating their decision- making, administrative, and narrative capacities and taking corrective action based on the findings that help to improve adherence levels(Caldarola et al., 2017). According to(Hess et al., 2015),key theme in the history of bioethics and, more precisely, health ethics was the discussion on patientautonomy.However, thelegislativeelement,i.e.,thetheory of reverencefor autonomy, was generally more concerned with medical ethics than with the theories of autonomy underpinning the concept. It emphasized the first aspect (the right that subjects must be permitted to select and act) and ignored the second element (their willingness to execute the choices they
3BIOETHICS chose freely). Most of the scientific literature focuses mainly on technical considerations of how to secure a right than on the psychological or contextual factors that underlie the capacity of patients to make independent decisions. This decision-making process can be propositioned in a manner similar to that usually practiced by sustainable and willing-bodied individuals, and accordingly, legal or legal notions of autonomy can be adequate and beneficial. However, these autonomy frameworks are much less suitable when it comes to chronic illness and primary medicine conditions(Blasimme & Vayena, 2016), where the contact between practitioners and patientsisdrasticallydifferent,andparticularchoicesaregenerallylessimportantthan preserving the partnership itself continuously. How and why the principal of autonomy is so often in conflict with the principle of beneficence (Using the issues of refusal of treatment and maternal fetal conflicts)? Pregnancy is exceptional in medical ethics because of the utter requirement to view the child only by the pregnant woman's influence in or diagnosis. Increasingly, when scientific developments give the child the possibility of treatment(Edvardsson et al,. 2015), physicians, decision leaders and the bioethics profession have regarded fetal needs independently from maternal interests. Despite this difference of priorities, maternal and fetal desires are generally related, and fetal treatment is associated with the pregnant woman and relies on her safety. Emerging treatments now provide the possibility of care for "fetal victims." Because of this emphasis, physicians, policy-makers and the bioethics profession have generally regarded fetal needsindependentlyfrommaternalinterests.Nonetheless,abortionpresentsaspecial professional morality situation, as the embryo can only be reached by the pregnant woman's involvement. While maternal and fetal interests are generally compatible, fetal treatment is
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4BIOETHICS interconnected and dependent on the treatment of the pregnant woman and often tension between fetal and maternal interests will occur. Where there is a dispute between maternal and fetal preferences(Meredith, 2016)(e.g., maternal rejection to care that would help the fetus), therefore a number to ethical mechanisms may guide therapeutic decision-making, in addition to strategies focused on theory. Helpful methods include feminist philosophy, case-based research, and treatment ethics, as well as values of dignity,charity or nonmaleficence, and fairness.Further states in his book about the maternal-fetal dispute issues are frequently emotionally motivated, and may benefit from a thorough study that involves a range of viewpoints. Basically, moral philosophy instructs the health care professional to recognize the informed consent or refusal of service of the pregnant patient due to her dignity and physical integrity, as well as her beliefs about the result of the birth. In situations where a woman's action may injure her child, violence to compel care is rarely acceptable in ethical terms. Judicial procedures have been tried in exceptional situations. Nonmaleficence(Al-Bar & Chamsi-Pasha, 2015)is the obligation not to injure or inflict injuries, which is well understood in the full, primum non nocere ("Do no damage first."). Although there are certain nuanced differences between nonmaleficence and beneficence, they are mostly viewed as embodiments of a common concept. Taken together, these two concepts are applicable with nearly any care choice as each medical or surgical operation involves both advantages and hazards that need to be handled knowledgeably and carefully. Beneficence, the obligation to support the well-being of the individual, may also clash with the responsibility to maintain individual autonomy. As an example one can consider a woman will choose to deliver a critically malformed infant via cesarean as she thinks this operation would improve the likelihood of life for the
5BIOETHICS newborn, if only for a few hours(Levin, 2019). Nevertheless, the potential advantage to a "unviable" child cannot mitigate the dangers of surgical delivery to the mother, in the best judgment of the physician. In such a case, the role of the practitioner is further complicated by the need to acknowledge the social, physical, and moral well-being of the individual. Those are problems that are socially laden and include upholding women's freedoms and the fetus' best interests. Evidence suggests that maintaining a trustworthy, caring, competent partnership with the pregnant women usually contributes to greater maternal and infant safety changes.(Saunders, 2019) aids in exploring provider principles can uncover implicit, gender-based differences in the strategies of physicians to dispute management and promote collective decision-making for the pregnant patient and her health care family, while upholding the fundamental ethical concept of maternal autonomy. Why the slippery slope can be a persuasive argument in bioethics and critically discuss its use in debates about euthanasia and genetic revolution? In biomedical ethics the slippery slope theory has been a common and contentious method of logic. The slippery slope (de Beaufort & Hermeren, 2017)claim has been used in global bioethics of topics such as pregnancy, drug reform, doctors needing to report their HIV status, euthanasia and gene therapy. The applications for the above two subjects of legal debate have been more common, and the key cases addressed in this article are slippery slope claims regarding euthanasia and gene therapy. These are slippery slope claims precisely because, relying on a fact, these suggest that doing one thing can lead to a downward fall into something else that is undesirable. Most individuals actually don't believe there is something about human cloning that is ethically questionable. One might claim that there's nothing wrong with human cloning, and then question the slopist as an evidence to believe there is and thereby, by doing so
6BIOETHICS a person will weaken the argument's persuasiveness. The SSA is often frequently viewed as fallacious in terms of probability and confidence, since it is not realistic for us to look into the future and to predict that the resulting occurrence will arise. In the other side, denying the argument for the same purpose, too, is challenging! Yet no argument automatically renders this 'if, then' conditional suggestion irrational to say-it merely needs plausibility evaluation. Euthanasia(Fratschko, 2016)opponents also argue that allowing some type of procedure would result in a slippery slope trend, which would inevitably lead to non-voluntary or even involuntary euthanasia. The downward slope theory (de Beaufort & Hermeren, 2017), as extendedtotheeuthanasiacontroversy,arguesthatendorsingsuchprocedures,suchas physician-assisted suicide or voluntary euthanasia, would inevitably contribute to the adoption or executionofideasnowconsideredinacceptable,suchasnon-voluntaryorinvoluntary euthanasia. According to the article by (Porter, 2017)transhumanism is viewed as a quasi-medical philosophy aimed at encouraging a number of medicinal and human-enhancing purposes. Weak conceptions are distinct from strong conceptions in transhumanism, and it has been observed that strong conceptions are more controversial than mild ones. A specific critique is raised on Boström's support of transhumanism. It addresses different types of slippery slope arguments that can be used for and against transhumanism(Porter, 2017), and highlights one specific critique, moral arbitrariness, which undermines both weak and strong transhumanism. Eugenics (Powell, 2015)is a collection of values and behaviors aimed at increasing a human population's genetic consistency, usually by removing individuals and communities considered to be inferior, and encouraging those considered superior. Individuals from across the political spectrum were promotingeugenicproposalsduringthistime.Asaconsequence,severalnationshave
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7BIOETHICS implemented eugenic programs intended to enhance the consistency of the genetic resources of theircommunities.Theseinitiativescontainedbothoptimisticsteps,theseaspromoting individuals deemed especially "worthy" to replicate, and punitive measures, such as marriage prohibitions and compulsory sterilization of people judged inadequate for reproduction. Some also described future "eugenics battles" as the worst-case eugenics scenario. This scenario would mean the restoration to systematic state-sponsored racial apartheid and abuses of human rights, such as forced sterilization of people with genetic disabilities, murdering the institutionalized and, actually, racism and genocide of races viewed as inferior, which gradually developed into a slippery case. What is meant by technological imperative and show how it is at work in bioethics? During a medicine and technology colloquium conducted in 1980(Tobbell, 2018), it was claimed that medicine had a scientific imperative. This can be described when basic instruments and strictly functional extensions of the physician's personal approach to the patient have become fundamental,self-propagating,essentialandalmostautonomouselementsofpresent-day biomedicine, particularly in the last 80–100 years. Medical technology(Meskó et al., 2017)has evolved from being a tool to being a partner and, in some instances, a practitioner master. There is no evidence, though, that the technical urgency problem has become less urgent, or that technology is being implemented more rationally in health care in the 21st century than it was in the 1980s. In the opposite, it is claimed that technological use has been widespread, and that health care practitioners are fascinated with technological. There is a new ownership and drive of education, and a demand and traction of manufacturing. In fact, it is believed that there is undue inquisitiveness regarding technology, and that doctors appear to be wedded to technology. A
8BIOETHICS unhealthy dependence on technology appears to occur, because technology has become the ideology of our society. (Forsberg et al, 2016) discusses in his study about how organ transplantation has gained much media nowadays, and has created a great deal of anxiety socially. The biggest concern is the disparity between the need for an organ donation and the amount of organs available for transplantation. Patients usually endure not only the discomfort induced by organ failure, but also social stresses when waiting for stable organs to be provided. There are significant improvements in different organ donation procedures today, which are divided into two general groups. Homograft(Sreevidya & Rejimon, 2017)is used because, given their hereditary variations, both the donor and the cell receiver have tissue, or the organ belongs to one biological group. Another approach is implemented where the sender and the receiver belong to the two same biological groups, termed Xenografts(Hoffman, 2015). Newborn infants are among the hardest affected by humanitarian crises. Aid agencies are becoming particularly mindful of the need to pay for newborns' medical needs, however this may raise distinctive ethics concerns for those offering emergency medical care. Despite the complexity and uncertainty of humanitarian crises,andthesevereresourceconstraintstypicallyencounteredbyhumanitarianrelief operations, professional ethical solutions to neonatal treatment popular in other settings might not be suitable. Developing detailed ethical principles in international environments pertaining to premature babies(Levin, 2019)faces a significant challenge. A signature aspect of humanitarian medical ethics is the challenge in identifying a consistent collection in standard procedures of humanitarian medicine.
9BIOETHICS Conclusion: The concept of not doing damage to anyone offers the justification for a patient's legal right to deny medical care, and for a practitioner to withdraw from interfering against the interests of the patient. Nevertheless, many scientistsclaimed that stopping individuals from injuring themselves was appropriate, because their acts were not completely aware. Nowadays, an autonomous decision may be defined by a reasonable individual as one that is taken freely / without unreasonable interference, in complete awareness and comprehension of the related facts required for such a decision. Self-determination is a core concept of health care, which increasingly shifts away from a paternalistic model to a more individualistic, customer-centered system where the patient takes a more active part of his / her own safety and well-being. Such an strategy allows patients to accept accountability for their own decision taking and therefore to face the implications of such decisions.
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12BIOETHICS Hoffman, R. M. (2015). Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneousxenografts.NatureReviewsCancer,15(8),451-452. doi.org/10.1038/nrc3972 Kalra, J. J., Campos-Baniak, M. G., Saxena, A., & Rafid-Hamed, Z. (2019, July). Medical Error Disclosure-A Canadian Perspective in Improving Quality of Health Care. InInternational Conference on Applied Human Factors and Ergonomics(pp. 26-34). Springer, Cham. doi.org/10.1007/978-3-030-20451-8_3 Levin, B. W. (2019). Catastrophically Ill Newborns: The Use of Technological Criteria.New Approaches To Human Reproduction: Social And Ethical Dimensions, 8. . Meloni, M. (2016).Political biology: Science and social values in human heredity from eugenics to epigenetics. Springer. Meredith, S. (2016).Policing pregnancy: The law and ethics of obstetric conflict. Routledge. Meskó, B., Drobni, Z., Bényei, É., Gergely, B., & Győrffy, Z. (2017). Digital health is a cultural transformation of traditional healthcare.Mhealth,3.doi:10.21037/mhealth.2017.08.07 Ong-Flaherty, D. N. P., Banks PhD, A., Doyle, M. S. N., & Sharifi, C. O. (2016). The meaning ofevidenceandnonmaleficence:casesfromnursing.OnlineJournalofHealth Ethics,12(2), 2.. doi.org/ 10.18785/ojhe.1202.02 Porter,A.(2017,June).Bioethicsandtranshumanism.InTheJournalofMedicineand Philosophy: A Forum for Bioethics and Philosophy of Medicine(Vol. 42, No. 3, pp. 237- 260). Oxford University Press.doi.org/10.1093/jmp/jhx001 Powell, R. (2015, December). In genes we trust: germline engineering, eugenics, and the future of the human genome. InThe Journal of Medicine and Philosophy: A Forum for
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13BIOETHICS Bioethics and Philosophy of Medicine(Vol. 40, No. 6, pp. 669-695). Journal of Medicine and Philosophy Inc..doi.org/10.1093/jmp/jhv025 Roskies, E. (2019).Abnormality and normality: The mothering of thalidomide children. Cornell University Press. Saunders, K. (2019).Relational reproduction: exploring women's reproductive decision making inthecontextofindividualization,neoliberalism,andpostfeminism(Doctoral dissertation, University of Glasgow).DOI:10.5525/gla.thesis.72988 Sautermeister,J.(2015).Xenotransplantationfromtheperspectiveofmoral theology.Xenotransplantation,22(3), 183-191.doi.org/10.1111/xen.12157 Sautermeister, J., Mathieu, R., & Bogner, V. (2015). Xenotransplantation—theological–ethical considerations in an interdisciplinary symposium.Xenotransplantation,22(3), 174-182. doi.org/10.1111/xen.12163 Searight, H. R. (2016). Guantanamo, anorexia nervosa, and death row: What are the limits of autonomy?.doi.org/10.1037/a0040316 Sorrell, J. M. (2017). Ethics: Ethical issues with medical errors: Shaping a culture of safety in healthcare.OJIN:TheOnlineJournalofIssuesinNursing,22(2). DOI:10.3912/OJIN.Vol22No02EthCol01 Sreevidya, P. S., & Rejimon, P. K. Transplanting Animal Organs Into Humans: The Ethics Of Xenotransplantation. Tobbell, D. A. (2018). Nursing’s Boundary Work: Theory Development and the Making of NursingScience,ca.1950–1980.Nursingresearch,67(2),63-73.doi: 10.1097/NNR.0000000000000251
14BIOETHICS Vangeli, E., Bakhshi, S., Baker, A., Fisher, A., Bucknor, D., Mrowietz, U., ... & Weinman, J. (2015). A systematic review of factors associated with non-adherence to treatment for immune-mediatedinflammatorydiseases.Advancesintherapy,32(11),983-1028. doi.org/10.1007/s12325-015-0256-7