Critical Article Analysis Validity Form for RCTs/Therapy studiesGroup Members: Gulzeb Memon and Bing WangPICO Question: Does intra-articular injection of Hyaluronic acid provide more clinical efficacy than standard corticosteroid injection in managing patients with major joint osteoarthritis? Article Citation and Link: Single intra-articular injection of high molecular weight hyaluronic acid forhip osteoarthritis.https://www.ncbi.nlm.nih.gov/pubmed/26449357Critical Appraisal WorksheetYESPARTIAL/UNKNOWNNOSCORESCREENING Did the study’s research design meet your inclusion criteria?If partial or no, explain: Inpatients and outpatients were not defined. Comparison withIntra-articular corticosteroid injection was not carried out. There are a number of relevant peer reviewed articles which were not included.321 2What was the study’s research question? The objective of the research article was to determine the safety and efficacy of intra-articular injection of a high molecular weight hyaluronic acid (Coxarthrum) for the treatment of hip osteoarthritis. Does the study’s research question (PICO) match your question PICO? The question does not compare the efficacy of intra-articular injections of corticosteroid and hyaluronic acid.3212VALIDITY Was the assignment of patients to treatments randomized? Centralized computer randomization is ideal; the METHODS section should tell you how patients were allocated to groups and if randomization was concealed.Explain your answer: The patients were allocated to groups based on the presence of partial hip disease, affected by hip disease for 3 months and those with good joint mobility. However, they carried out an unblinded study which is not favorable for randomized clinical trials.3211Were the groups similar at the start of the trial? Look in the RESULTS section for description of group similarity; a table may compare groups on a number of variables that may affect the outcome – ie age, risk factors, etc.Explain if partial or no: A table is not provided that compares the variable outcomes associated with age of the patients and risk factors.3211Aside from the allocated treatment, were the groups treated equally? YesThere should be no additional treatments or tests; look in METHODS section.Explain if partial or no:3213Blinding: Were patients, health workers, and/or study personnel “blind” to treatment?It was an unblinded study.Double blinding is best – both patients and investigators are unaware of treatment allocation; look in METHODS.3211Subject Mortality: Were all patients who entered the trial properly accounted for and attributed at its conclusion?Yes, it was between 0.5%.Losses to follow-up should be less than 20%; the RESULTS section will clarify the number and reason for losses to follow-up. Patients should be analyzed in the groups to which they were randomized (“intention to treat analysis”).32131
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