Advantages and Disadvantages of Therapeutically Inhibiting CDK5 in Cancer Patients and Alzheimer's Disease

Critically discuss advantages
and disadvantages of
therapeutically inhibiting
CDK5 in cancer patients and
in those suffering from
Alzheimers disease

Table of Contents
INTRODUCTION......................................................................................................................3
MAIN BODY.............................................................................................................................3
CONCLUSION..........................................................................................................................7
REFERENCES...........................................................................................................................8
Books and journals.................................................................................................................8

INTRODUCTION
Biomedical sciences are a group of disciplines that utilise elements of natural science,
organised science, or both to establish information, interventions, or technologies for
healthcare and public health (Allnutt and et.al, 2020). Medical sciences include fields
including medical microbiology, clinical virology, clinical epidemiology, genetic
epidemiology, and biomedical engineering. Pathophysiology, on the other hand, may be
considered natural science when it comes to explaining biochemical pathways that operate in
pathological processes. This essay is based on discussion critically discuss advantages and
disadvantages of therapeutically inhibiting CDK5 in cancer patients and in those suffering
from Alzheimers disease.
MAIN BODY
Cancer is a term used to describe a category of diseases characterised by irregular cell
growth that has the ability to infiltrate or spread to other areas of the body. Benign cancers,
on the other hand, do not multiply. A lump, unusual bleeding, a persistent cough, sudden
weight loss, and a decrease in bowel movements are all possible signs and symptoms. While
these signs and symptoms can signify cancer, they may also indicate something else. Humans
are affected by over 100 different forms of cancer. On the other side, Alzheimer's disease is
an irreversible, cumulative brain disease that gradually erodes memories and cognitive
abilities, as well as the capacity to perform even the most basic activities. Symptoms occur in
the mid-60s in the majority of patients of the disease (those with the late-onset type). The
protein encoded by this gene is a prolife-directed serine/threonine kinase that belongs to the
cyclin-dependent kinase family (Brandt and Mansour, 2016). Contrary to other family
members, the protein encoded with the gene does not specifically regulate the regulation of
the cell cycle. Instead, the enzyme, often expressed in neurons of the postmitotical
mammalian central nervous system at high concentrations, acts in various processes such as
synaptic plasticity and neuronal migration through phosphorylation of the proteins required in
cytoskeletonal organisations, endocytosis, exocytosis and apoptosis. Although most CDK5
research has focused on the nervous system, its non-neuronal mechanisms have long been
neglected. CDK5 appears to control a wide range of functions outside of the nervous system,
including cell cycle progression, apoptosis, DNA damage response, metabolism,