This article discusses the various methods to prevent cross infection in dental settings, including standard precautions, HTM 01-05 requirements, cleaning and disinfection, and hand washing. It also covers the importance of clinical area preparation and dental personnel immunization against certain diseases. The article further explains the causes and routes of transmission of microorganisms, and the different infectious conditions that can affect adults, older people, young children, and those with special needs in the dental setting. Lastly, it describes the different decontaminants used in dental surgeries and their effectiveness against microorganisms.