Research and Critical Analysis on Dermal Fillers and Antiwrinkle Injections for Skin Rejuvenation

This research paper provides a critical analysis of the complications associated with using dermal fillers and antiwrinkle injections for skin rejuvenation. It evaluates the effectiveness of different research papers and their methodologies, constraints, and ethical considerations. The paper also discusses the role of citations and the findings of the research.

Research and critical
analysis

Table of Contents
INTRODUCTION...........................................................................................................................3
Research paper 1..............................................................................................................................3
Background of research paper 1: ................................................................................................3
Methodology used in research....................................................................................................3
Research constraints that author might have encountered..........................................................4
Role of ethics in research encountered........................................................................................5
Research makes effective use of citations...................................................................................5
Effectiveness of arguments articulated and findings..................................................................6
Research paper 2:.............................................................................................................................6
Background of the research paper:..............................................................................................6
Methodology used in research....................................................................................................6
Research constraints that author might have encountered..........................................................7
Role of ethics in research encountered........................................................................................7
Research makes effective use of citations...................................................................................8
Effectiveness of arguments articulated and findings..................................................................8
Research paper 3..............................................................................................................................8
Background of research paper 3:.................................................................................................8
Methodology used in research....................................................................................................9
Research constraints that author might have encountered..........................................................9
Role of ethics in research encountered........................................................................................9
Research makes effective use of citations...................................................................................9
Effectiveness of arguments articulated and findings................................................................10
CONCLUSION..............................................................................................................................11
REFERENCES..............................................................................................................................12

INTRODUCTION
The research topic is based on Dermal fillers and antiwrinkle injections treatments for
skin rejuvenation. Presently there is analysis of the complications associated with using of
dermal fillers facial aesthetic procedures that is a expert group consensus report (Nisreen
Mobayed, Julie & Jared Jagdeo, 2020). There is evaluation of two research paper that are
selected based on the laid investigation. There are two research papers which are selected one is
based on preventing the complications that are related with dermal fillers in facial aesthetic
procedures that is a expert group consensus report. Another research paper is a investigation
based on the laid aims and objectives. The main aim is to analyse the another face of dermal
fillers. This research work is based on evaluating the complications of dermal fillers that is
depended on the site of application. This report is based on analysing and evaluating the different
perspectives of the research work.
Research paper 1
Background of research paper 1:
In this research paper there is analysis of the way dermal filers are invasive facial aesthetic
procedures have become increasingly popular. With the increasing number of procedures there is
increasing complications. It includes analysing the way dermal fillers are being used as per the
market requirements and the availability of products (Grand-Vincent & et.al., 2017). The main
aim of this research work is to offer a summary of various factors that might posses a influence
on the results of dermal fillers in aesthetic procedures and the way it can be prevented
(Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic
Procedures: An Expert Group Consensus Report, 2017).
Methodology used in research
The methodology used in the present research is based on secondary available information. In
this method the information related with the way there are number of procedures and the
complications that may arise for patients.

This research is based on 21 may, 2016 there is multidisciplinary group of experts that is used in
aesthetic treatments for the purpose of analysing the main factors that influence the
complications associated with the use of dermal fillers. In this the initial document is drafted by
coordinating committee and it was further reviewed by the panel members (Bell & Kelso,
2021). There was a published literature search for Spanish, English and French articles that was
published and performed by using of terms soft filler decompactions or “decompactions” or
“injectable complications” and “dermal fillers”.
The panel associated with research work address the consensus recommendations related with
the procedure, preparation and the post procedural care. The panel is mainly considered
important to obtain the accurate medical history for prevention of future potential complications.
In addition with the clinical assessment that includes standardised photograph it is also crucial to
evaluate the various outcomes and prevent potential complications. Further, the state of operating
theatre the patients health status and preparation of skill are also critical for prevention of
superficial soft tissue infections (Boen, Alhaddad, Wu & Goldman, 2020). Further in the
research work there is selection of appropriate techniques that is based on the experience of
physician's experience that is the characteristic's of filler and patient to ensure successful
outcomes.
Secondary data analysis is based on using the already existing information that is collected by
someone else for their own purpose. In the present research work researcher is using secondary
data analysis for the purpose of answering the new research question or for the purpose of
examining the alternative perspective of original question that is part of previous study. There
are may benefits associated with using of secondary data analysis such as it helps in storing of
information in proper electronic format that leads to researcher analysing the data and further
preparing its analysis.
In the research work there was more rely on secondary sources accuse secondary sources are
closely linked to primary research. The journal article is presenting the results of the scientific
study of the author and the views that is based on case studies. These sources are adding value
that can help in the process of having proper findings as part of research work.

Research constraints that author might have encountered
In the context of selected research papers there may be some difficulties and constraints that
researcher might have encountered during this process of collecting the information:
There was no presence of primary information as the information base was completely based on
available secondary sources of information. So there can be issue of reliability of information
which may affect the way authenticity of the overall information base in the present report.
Another constraints was related with aesthetic procedures that is usually elective process where
clinical trails may be complex to conduct and organise (Donnell, Woolley & Worthington,
2021). There are few prospective trails but they may not be controlled or randomised, the
knowledge base mainly comprises of case reports & is based on summary of individual
practitioners experiences.
Another research constraint that arise in the process of study was related to dealing with the
situation of plagiarism. The research paper is based on collection of secondary sources that is of
particular topic. The research paper is based on using the information from already existing
sources so it may be difficult to distinguish between the process of conducting the research as the
researcher is planning the paper. In some situation the failure can lead to situation of plagiarism.
When the information and data is collected from already existing information it may lead to
difficulty in the process of reducing the level of similarity. So researcher has to properly consider
that any act in the research work is not leading towards plagiarism.
Role of ethics in research encountered
The role of ethics is related with the aspects that information is not leaked or there is no loss of
information. The research has to be planned in such a way that there are no misleading results
there must be proper following of ethical procedures during the research work. The collected
information must also be validated by ensuring that there are journal articles that are properly
considered by the researcher in the course of collecting the information (Robin & et.al., 2021).
The research is also planned in such a way so that it is not providing any types of results that are
misleading. It is to be ascertained that all the ethical procedures that are to be duly followed in
the research work.

Research makes effective use of citations
In the research paper the references that were cited in the select articles were reviewed for
identification of additional relevant report. There were also published relevant national &
international guidelines that were scrutinised.
Effectiveness of arguments articulated and findings
The main findings of this research paper is based on understanding of the key elements that can
help clinicians who are starting to make use of dermal fillers to employ standard procedures for
the purpose of understanding the best way to prevent potential complications of treatment
(Goldberg, 2017).
The consensus document is based on dermal fillers vary in the composition, ease of
administration, limitations of fillers.
Research paper 2:
Background of the research paper:
In this the main aim of the study is to analyse the possible complications that are related with the
dermal fillers. The main aim is to analyse the aetiology and prevention of treatment and
management of dermal fillers. There are many complications that are associated with using of
dermal fillers (Reinholz & et.al 2020). The main aim of the study is to identify such adverse
effects or creations of injection site, brushing or induration that may arise in the process of using
of dermal fillers.
Methodology used in research
There is use of secondary methodology for the purpose of conducting the research work. There is
no primary form of information that is collected by the researcher. This study is mainly
conducted in the department of oral surgery and periodontology that is the Poznan university of

medical sciences. There is use of already available information that is for the purpose of
conducting this study there is no use of primary form of information or first hand information.
Using of secondary data analysis is a very helpful cost effective alternative that can help in
analysing the process of collecting data and reaching to better
In some instances the use of secondary sources are easy and quick and it also offers higher
credibility and perspective of the research secondary data is very helpful as it provides data with
furthering research through added perspectives and question. In the present research there is
validating of the existing data by revealing of discrepancies. There is a added layer of trust and
credibility that may be created by cross verification of the sources from where the information is
collected by the researcher in the present research work.
Research constraints that author might have encountered
There are several research constraint that may arise in this context that is related to limited
availability of information on the laid research topic. Apart from this there were also issues that
are related to the availability of sufficient information base.
The main constraint of the study are related to the characteristics of methodology or design that
may posses influence or impacted the interpretation of the research findings. There are some of
the constraints that are related with applications of practise, generalizability, utility of findings
that are result of the ways (Guarise & et.al., 2019).
Another constraint is identification of authentic and reliable sources that can also arise in the
present research work where the researcher might face several difficulties with respect to
analysing the reliability of source for the purpose of suing it to have sufficient information base.
A plagiarism a situation that is misrepresenting other or already existing work. Sometimes
writers may plagiarise the work on purpose where they are pasting or copying other persons
original course of work it may lead to instance of negative consequence.
Role of ethics in research encountered
Ethics are related with overall standards of conduct. It is based on ensuring that there is maintain
of proper consideration of all ethical principles in the research work. There is requirement to
disclose about the personal and financial interest that may indirectly or directly affect the work.
Using the research ethics the main focus is related with protection of dignity of subject and the
process of publication information. Ethics is incidental with the branch philosophy that is dealing

with the dynamics of decision making. There is introduction of protecting the human rights that
are part of the research (Dua, & Bhardwaj, 2019). The major weak point of this research was
related to self regulation of researcher that may be abused in some of studies. There can be
issues of anonymity and confidentiality that is related with addressing the confidentiality that is
management of private information in order to protect the identity of the subject.
Research makes effective use of citations
Citing of sources is very important for the purpose of avoiding the instances of plagiarisms, if
there is no proper citing of resources then it might lead to difficulty in the process of phrasing,
information, ideas when they are actual originated by the author. In present research there is use
of proper citations to ensure that there is evidence from where the information is collect by the
researcher for the purpose of achieving the laid aims and objectives of the research.
Effectiveness of arguments articulated and findings
The main argument that are articulated in the report is based on dermal fillers and the site of its
application. The overall classification of dermal fillers is based on major and minor events. The
main aim of the study is to evaluate the possible complications that are related to dermal fillers.
There is understanding of the aetiology and further there is proposing of the preventive treatment
and management (Vedamurthy, 2018). Non-ischaemic compilations are technique independent
and consist of the reactions of the injection site, contour irregularities and the overall infectious
reactions.
The argument have been articulated in such a way that facial fillers are offering adequate volume
of depressed areas of skin. It is helping in having a rejuvenated and youthful approach that has to
be maintained, soft tissue augmentation is getting more popular because of growing interest in
cheek reshaping and facial contouring. In present scenario dream fillers are presented as fluids,
bioecological garments, suspension of microspheres or particles each with a specific
implantation method.

Research paper 3
Background of research paper 3:
This research paper is based review of hydro-lifting that is a new modality for rejuvenation of
skin. Hydro-lifting is a modality of skin rejuvenation that is used for the purpose of enhancing
the facial volume augmentation and then recovering of the way skin thickening through multi
passing of HA injection (Chiang, Pierone & Al‐Niaimi, 2017) .
Methodology used in research
In this research paper there is review of the medical literature. Further, there is analysis of the
authors clinical experience, training and investigation of the skin wrinkles with using of hydro-
lifting method.
The main objective of the research is to define a novel technique of injecting HA and further
clarification of choosing a appropriate HA filler that is based on procedural purposes.
Research constraints that author might have encountered
one of the constraint that may arise in the medical paper is related with giving credit to the
sources the way they are quoted in the manuscripts. The result of a effective research work is
based on providing attention to details at all the levels of research work. So there can be issues
related with having proper evidence which may act as a constraint and can lead towards
difficulty in the process of reaching to relevant recommendations or conclusions.
Plagiarism may be prominent problem that is encounter in the academic process and is a
common issue of compromising the academic integrity of author. Proper referencing signifies the
quality of work and is a indicative of the extent to which information on a particular subject is
available.
Role of ethics in research encountered
Research ethics are related with the set of rules that govern the set of expectations of the author
and others behaviour. It is governing the standards of conduct for scientific researches that is a
guideline for responsibly conducting the research work.

Research makes effective use of citations
in the present research work the main aim of the researcher is to write publications with high
quality prose, argument, exceptional data and conclusions that are embedded in the literature.
With the inclusion of references there is demonstration of the foundation on which the studies
are based and the way they are different from other existing studies. The difference is based on
the literature is disprove or dispute, claims, arguments that are expanded in the research work.
Along with it there is development of suggestions and hypothesis of the published work. This
citation and proper referencing all through the research has helped in helping to understanding of
the source of information (Mlosek and et.al., 2021). Citation are also helpful in the context of
present regimes that is evaluating a particular perspective. The act of including of a particular
references in the study is a subject of value based criteria that is internal to science based on
credibility, relevance of the content, it is also external to science based on performance and
accountability of information.
Effectiveness of arguments articulated and findings
The main findings of the research is based on hydro lifting method that is a newly introducer
anti-ageing treatment modality,. It is covering the blind sports of conventional HA injection.
That includes perioral, infraorbital and hand dorsal wrinkles. However, it is concluded that
further investigation is required to reach a consensus in basic concept of treatment, optima
technique of hydro-lifting and choice of appropriate fillers.
The main results of the stuffy is based on HA fillers serving as a hydration sources, stimulator of
dermal collagen, antioxidants and dermal volumizer.

CONCLUSION
From the above made analysis of the three different types of research work that have
been select by the researcher. It is associated with the different ethical considerations, citations
and evidence that are used as source of referencing the work. Based on different aspects of the
studies conducted further findings are made and the overall laid aims and objectives are achieved
by the researcher.

REFERENCES
Books and Journals
Vedamurthy, M. (2018). Beware what you inject: Complications of injectables—dermal
fillers. Journal of cutaneous and aesthetic surgery, 11(2), 60. Available
through<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128162/>
Chiang, Y.Z., Pierone, G. & Al‐Niaimi, F., (2017). Dermal fillers: pathophysiology, prevention
and treatment of complications. Journal of the European Academy of Dermatology and
Venereology, 31(3), pp.405-413. Available
through<https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.13977>
Mlosek and et.al., (2021). The use of high-frequency ultrasonography for the diagnosis of
palpable nodules after the administration of dermal fillers. Journal of
Ultrasonography, 20(83), p.e248. Available
through<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830082/>
Dua, A. & Bhardwaj, B., (2019). A case report on use of cog threads and dermal fillers for
facial-lifting in facioscapulohumeral muscular dystrophy. Journal of cutaneous and
aesthetic surgery, 12(1), p.52. Available
through<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484573/>
Guarise & et.al., (2019). HA-based dermal filler: downstream process comparison, impurity
quantitation by validated HPLC-MS analysis, and in vivo residence time study. Journal of
applied biomaterials & functional materials, 17(3), p.2280800019867075. Available
through<https://journals.sagepub.com/doi/pdf/10.1177/2280800019867075>
Reinholz & et.al (2020). Dermal fillers do not induce upregulation of NLRP3 inflammasomes or
expression of inflammatory cytokines in granulomas. Journal of cosmetic
dermatology, 19(11), pp.2838-2844. Available
through<https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.13341>
Goldberg, D.J. ed., (2017). Dermal Fillers. Karger Medical and Scientific Publishers. Available
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Robin & et.al., 2021. Efficacy of a biorevitalizing-filler solution on all skin aspects: 10 years
approach through in vitro studies and clinical trials. Journal of Cosmetics, Dermatological
Sciences and Applications, 11(1), pp.18-
37.https://www.scirp.org/journal/paperinformation.aspx?paperid=107606>
Donnell, C. C., Woolley, J. J., & Worthington, S. W. (2021). Advertising and facial aesthetics in
primary care: how compliant are practice websites and social media with published
guidance?. British Dental Journal, 1-9..https://www.nature.com/articles/s41415-021-2718-
4
Boen, M., Alhaddad, M., Wu, D.C. & Goldman, M.P., 2020. A Prospective Double-blind,
Placebo-controlled Clinical Trial Evaluating the Efficacy of a Novel Combination of

Hyaluronic Acid Serum and Antioxidant Cream for Rejuvenation of the Aging Neck. The
Journal of Clinical and Aesthetic Dermatology, 13(11),
p.13.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716741/
Grand-Vincent & et.al., 2017. Clinical assessment of a mesotherapy formulation for skin
rejuvenation in healthy volunteers. Journal of Cosmetics, Dermatological Sciences and
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paperid=80242
Nisreen Mobayed, B. S., ª Julie, K., & Jared Jagdeo, M. D. (2020). Minimally invasive facial
cosmetic procedures for the millennial aesthetic patient. Journal of Drugs in
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online:
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Another face of dermal fillers, 2020 [online], Available
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