Pathophysiology of Diverticulitis

This article explains the pathophysiology of diverticulitis, including chronic inflammation, altered microbiomes, alterations in colonic neuromusculature, and genetics. It also discusses the connection between diverticulitis and intestinal mucosal inflammation, as well as the role of gut microbiota in the disease.

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Pathophysiology of Diverticulitis
Pathophysiology for Diverticulitis is explained as follows:
Chronic Inflammation,There are several studies which are related to diverticulitis which
is a chronic inflammatory state. There are various risk factors related to diverticulitis which are
related to chronic and systemic inflammation which is indirect evidence for the disease. there is
various expression which are related to the diverticulitis which are increasing such as Matrix
metalloproteases and histamine are one of them. The disease of intestinal mucosal inflammation
which is present in the patients consist of morphological and clinical overlap with the IBD. There
is no connection of diverticulosis with the Irritable Bowel Syndrome (Schieffer, K. M & et.al.
2018).
Altered Microbiomes, Pathogenesis is implicated in various intestinal disorder when
alterations are made in the gut microbiota. Mucosal inflammation and diverticulitis takes place
due to diet and lifestyle which is inducing alterations in the gut microbiome. There are various
evidence which are in support that gut microbiota has a role in diverticulitis. Acute diverticulitis
consists of micro and macro perforation which are there in translocation of commensal bacteria.
These bacteria are present in colon mucosal barrier which is providing results in frank infections.
This infection can be of abscess formation and peritonitis (Munie, & Nalamati, 2018).
Alterations in Colonic Neuromusculature, The diverticulitis can be increased when there
is a change in the neuromusculature which can result into the formation of the diverticula in the
weak spots that can be seen in the colonic musculature (Craft and et.al., 2017). The diverticulitis
can be seen mostly in the sigmoid where the amount of colon is less than proximal colon and
rectum. The early diverticulosis is mostly found in the patients who are suffering with the
problems of the connective tissue disorders. It can be identified that the problem of connective
tissue metabolism is been identified in the patients who are suffering with the disease of the
diverticulosis.
Genetics, The various studies have provided that the diverticulitis can also be seen as the
disease that is being founded in the patient because of the genetics. The odds of developing the
disease of the diverticulitis can be seen if the co-twins have the disease. The chances of the
disease in the co-twins is significantly higher among the monozygotic twins than the dizygotic
twins. However, the studies is still not able to clearly identify the difference between the

diverticulitis and the diverticulosis disease which still makes it difficult to understand that
whether the disease can be a result of genetics or not.
REFERENCES
Books and journals

Craft, J. and et.al., 2017. Understanding pathophysiology - ANZ adaptation (3rd [Australian and
New Zealand edition]. ed.). Chatswood, N.S.W: Elsevier.
Schieffer, K. M & et.al. (2018). Pathophysiology of diverticular disease. Expert Review of
Gastroenterology & Hepatology. 12(7). 683-692.
Munie, S. T., & Nalamati, S. P. (2018). Epidemiology and pathophysiology of diverticular
disease. Clinics in Colon and Rectal Surgery. 31(04). 209-213.