This research aims to study the impact of drug and alcohol combine consumption on the biochemical activity of the body or internal changes in organ function caused by this. The lack of information on how drugs and alcohol combine use causes death and what changes it possesses on the internal function like biochemical processes of the body is the research gap that this study aims to fill. The research questions include the basic concept of drugs and alcohol combine use and impact, the exact biochemical changes caused by drugs and alcohol in the body, and the types of health conditions caused by drugs and alcohol-induced biochemical changes. The methodology includes primary research in the lab with key methods of biochemistry and secondary research to get relevant information for conducting this research. The timeline for this research is seven months.