THE END POINT DETERMINATION

Running head: END POINT DETERMINATION
End point Determination and study of Developmental Neurotoxicity
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END POINT DETERMINATION1
Neurotoxicology is the knowledge of the detrimental factors on the nervous system
by actions of pesticides, biological, and certain physical agents throughout growth and
maturity. Several specific chemicals, like arsenic, mercury, contaminants, and ethanol, are
toxic to the nervous system [1].
Neurotoxicity is a significant hazard target for many regulatory body functions that
must be assessed. To identify potential neurotoxic agents, neurotoxicity testing is used.
Neurotoxicity monitoring is often considered as an element of location bound organ toxicity;
one of the prime target body systems is the central nervous system (CNS). Pesticide and
medication exposure in utero can also have harmful effects on the growth of the nervous
system, which is considered as developmental neurotoxicity [2].
The end points studies for various toxicity include the study of developmental toxicity
which is the toxicity in the fetus which are death, retardness of development, anatomical
changes, extreme external deformities, soft tissue / major organ abnormalities. Another
toxicity refers to the reproductive toxicity that is the toxicity by the parents which impacts the
deformities in the organs for reproduction which can lead to changes in sex ratio, the viability
of the offspring, development and characters.
Moreover, carcinogenicity neurotoxicity is one of the most impactful neurotoxicity,
which implements the formation of carcinogens in individual producing tumors in them. In
addition, mutagenicity is the last count among the effects of toxicity which impacts by
flowing from the generations and can even alter with the phenotypes of the offspring.
First-tier evaluation is designed to evaluate how well a chemical has the capacity to
produce any neurotoxic effects, i.e., the first phase of the risk management process to enable
risk detection. The next stage is dealing with neurotoxicity classification, such as the form of
structural or operational damage caused and the extent and position of synaptic failure. Tests