Epidemiology: Control of Confounding Variables and Outcomes Measurement
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This paper discusses the control of confounding variables in epidemiology and the measurement of outcomes. It identifies the confounding factors and strategies for controlling them. The paper also highlights the limitations of the study, such as unreliable and invalid outcomes measurement and a long exposure period.
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Running head: EPIDEMIOLOGY Epidemiology Name of student: Name of university: Author note:
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1 EPIDEMIOLOGY 6. Confoundingvariablesarethefactorsthattheresearchersarenotsuccessfulin controlling or eliminating, thereby leading to an influence on the internal validity of the experiment(Pope andStanistreet2017;Berkmanetal.2014). Inthepresentpaperthe researchers were successful in identifying the confounding factors. These were age, first-degree family history of PCa, ancestry, education, reported family income, marital status, smoking, dietary habits, alcohol consumption, history of diabetes and neighborhood material and social deprivation (Demoury et al., 2017). 7. ControlofconfoundingvariablescanbeachievedbymeasuresofRestriction, RandomizationandMatching(Bowling2014;DePoyandGitlin2015).Theresearchers mentionedthatstrategiesforcontrollingtheconfoundingvariables.Threemodelswere considered and developed for adjusting for age, ecological characteristics, and individual characteristics through estimation of relative risks associated with increase of normalized difference vegetation index NDVI andinterquartile range (IQR). 8. The outcomes were not measured in a reliable and valid method. Interviews were conducted for data collection that increased the chances of under reporting or over reporting of the outcomes. It is noted that when data collection is done with self-reporting tools, the
2 EPIDEMIOLOGY objectivity of the study is highly compromised (Westfall and Yarkoni 2016; Szklo and Nieto 2014). 9. Data collection was done between the years 2005 and 2012. This implies that the exposure period of the study participants were too long. Risks are likely that the starting point and end point of the experiment, certain factors might have influenced the variables measured (Koch 2014;Greenland and Pearce 2015).
3 EPIDEMIOLOGY Reference Berkman, L.F., Kawachi, I. and Glymour, M.M. eds., 2014.Social epidemiology. Oxford University Press. Bland, M., 2015.An introduction to medical statistics. Oxford University Press (UK). Bowling, A., 2014.Research methods in health: investigating health and health services. McGraw-Hill Education (UK). Demoury, C., Thierry,B., Richard,H., Sigler,B., Kestens, Y. and Parent, M.E., 2017. Residential greenness and risk of prostate cancer: A case-control study in Montreal, Canada. Environment international,98, pp.129-136. DePoy,E.andGitlin,L.N.,2015.IntroductiontoResearch-E-Book:Understandingand Applying Multiple Strategies. Elsevier Health Sciences. Greenland, S. and Pearce, N., 2015. Statistical foundations for model-based adjustments.Annual review of public health,36, pp.89-108. Koch, G., 2014.Basic allied health statistics and analysis. Nelson Education. Pope, D. and Stanistreet, D., 2017.Quantitative methods for health research: a practical interactive guide to epidemiology and statistics. John Wiley & Sons. Szklo, M. and Nieto, F.J., 2014.Epidemiology. Jones & Bartlett Publishers. Westfall, J. and Yarkoni, T., 2016. Statistically controlling for confounding constructs is harder than you think.PloS one,11(3), p.e0152719.