The provided content presents various studies and articles related to substance use disorders, including comorbidities with mental illnesses, early intervention strategies, and the impact of age at first alcohol use on the development of alcohol disorders. Additionally, it highlights the importance of relapse prevention, particularly among individuals with severe mental illnesses. The articles also explore the effects of substance abuse on utilization of mental health services, costs of care, and violence associated with severe mental illness. Furthermore, it discusses prenatal substance abuse, its short- and long-term effects on the exposed fetus, and the potential impact of the baby-boom generation on substance abuse among elderly persons.