Essay on Alzheimer’s Disease

Added on - 26 Nov 2019

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Running head: ALZHEIMER’S DISEASE1ESSAY PLAN FOR ALZHEIMER’S DISEASENameInstitution
ALZHEIMER’S DISEASE2Paragraph 1: Explanation of “positive” lesions and “negative” lesions of Alzheimer’sThe neuropathological hallmark changes of in the brain of a person presenting withAlzheimer’s disease include both ‘positive’ and ‘negative’ lesions. Explain why some of thelesions are regarded as positive whereas others are regarded as negative. Also, differentiatebetween the macroscopic and microscopic features which characterise the condition.Paragraph 2: Research on the “positive” lesionsDiscuss the classical positive lesions of Alzheimer’s disease. These include neurofibrillarytangles, amyloid plaques, dystrophic neurites containing hyperphosphorylated tau, andneuropil threads[ CITATION Alb11 \l 1033 ]. Discuss the composition and themorphological characteristics of these features. Base this research on the papers bySerrano-Pozo, Frosch, Masliah, & Hyman, (2011), and Perl, (2010) as they offer an in-depth researchinto these lesions.Paragraph 3: Research on the “negative” lesionsThese are the classical ‘negative’ lesions present in patients presenting with the disease.According toSerrano-Pozo, Frosch, Masliah, & Hyman, (2011), the core negative features ofAlzheimer's disease includelosses of neurons, neuropil, and synaptic elements. Explain thecomposition and morphological characteristics and relate them to the ‘positive’ lesions. Ontop of the two research papers used in the discussion of the ‘positive’ lesions, an additionalresearch paper byPithadia, (2008) will offer more information.Paragraph 4: Research on a patient's history as one of the clinical features resulting frompathological changes caused by Alzheimer's.
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