Diabetes and Alzheimer's Disease: Shared Pathology

The provided document is a comprehensive analysis of the relationship between diabetes and Alzheimer's disease. It includes various references from books and journals that discuss the shared pathology and treatment implications between these two conditions. The document also explores how diabetes can be a risk factor for dementia and mild cognitive impairment, and how certain medications may have protective effects on the brain. A summary of key points and a discussion of relevant studies are included in the document.

ESSAY

TABLE OF CONTENTS
INTRODUCTION...........................................................................................................................1
MAIN BODY...................................................................................................................................1
CONCLUSION................................................................................................................................4
REFERENCES................................................................................................................................6

INTRODUCTION
Diabetes is a severe disease due to which ability of an individual to respond to hormone
insulin is impaired. Food which is intake by different individuals gets converted into glucose
which helps human body in performing different functions as through this, energy is produced in
body. There were earlier 2 types of diabetes but now in the recent era, researchers have
introduced type 3 diabetes which is known as Alzheimer's disease (Akter and et. al., 2011).
Following essay will discuss Alzheimer's type 3 diabetes in special reference to the potential
detrimental role of a high carbohydrate diet.
MAIN BODY
Alzheimer's is a disease in which person suffering face problem in remembering things.
There recognising power gets reduced and other memory related issues also arise . Once an
individual is affected by this disorder, it keeps on developing and no permanent solutions are
present in the existing medical science. Alzheimer's is a mental deterioration which is mostly
found in the people falling under age group of above seventy or eighty. It is a dangerous health
issue as person suffering from same comes across various problems which make it difficult for
the victim to carry out day to day operations (McClean and wt. al., 2011). It gets worse over a
period of time and makes the life of patient imaginable. Different side effects of this disease are
problems in maintaining focus, finding it difficult to perform day to day operations, developing
irritating feelings with the surroundings and others which are associated with physical problems
like development of already available door health. It is considered as type 3 disease in which
having much of carbs and less of fat create damage in the brain. It is prevented by substituting
carbs whit fat. According to research, it is said that people suffering from diabetes are more
prone to get affected by this health issue. Doctors say that victims of pre- diabetes can easily get
affected by pre – dementia. Excess of sugar is found in brain that develops diabetes (Barbagallo
and Dominguez, 2014). It shows that this disease is another form of diabetes curing process of
which is also similar. Due to lack of glucose in body, the whole functioning gets disturbed and it
becomes important that precautions are taken against the same. It is the major reason behind why
it is termed as diabetes and specially brain disease. Earlier, it was difficult to construct a
connection between type 2 diabetes and dementia but now due to the availability of research
results it is said that Alzheimer's disease is a sub part of the discussed health problem. People
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suffering with diabetic issue are more prone to get effected by dementia disease because due to
problem in the flow of blood in the body this health issue take place.
By taking corrective measures on time, person suffering with diabetes can save himself
from Alzheimer. Role of blood relations is also much in getting effected by diabetes and then
dementia and therefore similar precautions are taken in both the cases (Liu and et. al., 2011).
people inherit sugar problem from their parents or from blood relatives and transfer same in
future generation. Regular exercise is suggested to the patients of Alzheimer's. It helps in both;
controlling diabetes level and boosting control over mind too. Specifically aerobic exercises are
of great use as it facilitates usage of illness more effectively. Eating habits also play a major role
in recovering or minimising the effect of Alzheimer's. Intake of herbs and spices are suggested to
person suffering from these diseases as it lowers the added sugar quantity in human body.
Excessive weight leads to major issue like obesity, diabetes and fat around tummy raises the
heart related issues in a person which can be managed by adopting healthy physical habits which
can help in reducing the overall fat from body (Bomfim and et. al., 2012). Doctor suggests to
maintain tight blood sugar control so that the chances of being affected by dementia can be
reduced to minimum. Injections which are taken in use to control diabetes are also helpful in
protecting brain from various toxic amyloid proteins. Stress is a basic cause that increases the
degree of diabetes as well as other Alzheimer's related issues and hence the affected person
needs to do mediation so that mental peace is achieved and hence, there will be reduction in the
degree of risk (Hsu and et. al., 2011). Doing yoga provides inner satisfaction to an individual
which is important specially in case of diabetes. Tension is another major cause of this health
problem which gets reduced if proper mediation yoga's are done. There are the precautions
which if taken before hand then are of better use as maintaining a healthy mind is easier than
repairing an affected mind as in that case, degree of risk involved is higher. Other factors that
develop a strong relation between diabetes and the Alzheimer's is that due to type two diabetes,
abnormalities in brain occurs which are needed to be managed to avoid future issues. There are
common symptoms which are found in the person suffering from both diseases like obesity
(Type 3 Diabetes Symptoms, 2017). It is suggested to people suffering from both these problems
to get dementia tested so that level of glucose in body is determined. Apart from this, the other
similarity between both these health issues are that they are prevalent with age.
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The possible links are insulin processing, insulin receptors, acetylcholine inflammation
etc. almost similar mechanism is done in both the cases and glucose level is maintained so that
maintenance of sugar minimum sugar level is done. It is assure in each case that no defects is
made in the process as this way it would be easy to minimise the risk of loss. It is important for
human body to use insulin in an appropriate manner as it is the major hormone that regulates the
glucose level in a human body (Cheng and et. al., 2012). This way it becomes a basic
requirement in both the problems as maintenance of minimum glucose body level is of very
crucial nature. The different cardiovascular problems that are common in diabetes are also a part
of Alzheimer's which further makes the link between both stronger. Impaired blood vessels,
circulation problems, high cholesterol, obesity, high blood vessels and other heart related issues
are common in both the discussed health issues. Study says that people suffering from
Alzheimer's are incapable of making use of glucose efficiently which creates more health related
issues similarly like in case of diabetes. The cells which are responsible for making the message
understandable for user get effected and hence the ability of an individual to understand and
remember things gets effected. Patients of Alzheimer's are considered to be going through
diabetic state. Insulin resistance is shown by the people suffering from Alzheimer's which is
same in case of other mentioned disease which shows in what manner the mechanism of both the
problems are similar in a human body. As the disorder is same the treatment for both are similar
to one another to a great extent. Drugs that are capable of evaluating the blood brain barrier are
used so that normal functioning is maintained to the great extent to which it is possible (Ellison
and et. al., 2012).
The role of high carbohydrate diet is crucial in Alzheimer's which has now become a type
3 diabetes. It is a diet in which the amount of carbohydrates is either fixed or set to a limited
value. The Alzhimer is the disease which is occurred in human and characterized a chronic
neuro-degenerative disease which usually starts slowly and ends so badly over the time. If
anyone have this kind of disease, then the patients does not remember the things for the long
time. It is also called as the short term memory loss. Alzheimer is also occurred due to
the inadequate supply of insulin in the human brain and this can lead to create problems and
generate type 3 diabetes in human beings. This is mostly occurred genetically and also does not
have control over the diet. There is a need to have strict diet which contains low carbohydrates
and balanced fat diet as it will help in maintaining control effectively and patients can fight
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against the health issue with higher potential. However, the high carbohydrates diet adversely
affects the person who is having this disease. There are other risk factors which are also cause
Alzheimer which are: head injuries, depression or hypertension. This is linked with plaques and
tangles in the brain. It is of great importance for people suffering from both the discussed
disease to follow strict diet so that risk of this disease is minimised. It assist the victim to
maintain required level of insulin which is very much important to ensure proper functioning of
body. The best diet for the person going through each type of sugar problem is one which is best
integrated into the person’s lifestyle. It should be in accordance with the insulin regimen which is
required in a particular body (Holt and Kumar, 2015). An individual’s diet should be such that it
is high in carbs like taking oatmeal, beans and lots of other food products which are not starchy.
Food product that are rich in carbohydrates are helpful in developing the level of glucose in body
which is very much important. It is important that the quantity of carbohydrate intake is done as
per the prescription. To manage obesity also the use of same diet is done as it helps in keeping
control over the level of different nutrition so that a balanced diet is achieved which is capable of
fighting against the health issue (Fillit, Rockwood and Young, 2016). This concept is of such
importance that American diabetes association suggest that monitoring should be kept over
consumption of carbohydrate so that required level of proteins are received by the body. In order
to reduce the total fat of body strict low carbohydrate diet is being followed. If care is not given
to the level of intake than a person may find it difficult to find against the disease. Carbohydrate
diet is of great importance as it reduce the risk of this health problem and helps an individual to
fight against the problem. By including food products that are rich in carbohydrate regulates
proper functioning of body and helps in fighting against the illness. But on the same hand it also
creates problem for Alzheimer's as it worsen the condition if intake is done in excess quantity. It
has to be maintained in balance so that the unfavourable results are avoided and required level of
body requirements are met (Pan and et. al., 2011).
CONCLUSION
From the above discussion this has been summarised that Alzheimer's is one of the most
common form of dementia which is a common name use for problem associated with memory.
Gradually a person suffering from this health issue losses ability to perform different simple
tasks that are of daily routine nature. It occurs due to the reason that body of an individual
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develops non-acceptance against insulin which is important for the generation of glucose. It has
directly connection with the age of an individuals as mostly people above age of eighty five are
found with this health problem. It is not necessary that every person suffering from diabetes has
this disorder but a diabetic person is more prone to fall under the category of this issue due to the
fact that both of them share same physical disorders.
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REFERENCES
Books and Journals
Akter, K. and et. al., 2011. Diabetes mellitus and Alzheimer's disease: shared pathology and
treatment?. British journal of clinical pharmacology. 71(3). pp.365-376.
Barbagallo, M. and Dominguez, L. J., 2014. Type 2 diabetes mellitus and Alzheimer’s disease.
World journal of diabetes. 5(6). p.889.
Bomfim, T. R. and et. al., 2012. An anti-diabetes agent protects the mouse brain from defective
insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers. The Journal of
clinical investigation. 122(4). p.1339.
Cheng, G. and et. al., 2012. Diabetes as a risk factor for dementia and mild cognitive
impairment: a meta‐analysis of longitudinal studies. Internal medicine journal. 42(5).
pp.484-491.
Ellison, D. and et. al., 2012. Neuropathology E-Book: A Reference Text of CNS Pathology.
Elsevier Health Sciences.
Fillit, H. M., Rockwood, K. and Young, J. B., 2016. Brocklehurst's Textbook of Geriatric
Medicine and Gerontology E-Book. Elsevier Health Sciences.
Holt, T. and Kumar, S., 2015. ABC of Diabetes. John Wiley & Sons.
Hsu, C. C. and et. al., 2011. Incidence of dementia is increased in type 2 diabetes and reduced by
the use of sulfonylureas and metformin. Journal of Alzheimer's Disease. 24(3). pp.485-
493.
Liu, Y. and et. al., 2011. Deficient brain insulin signalling pathway in Alzheimer's disease and
diabetes. The Journal of pathology. 225(1). pp.54-62.
McClean, P. L. and wt. al., 2011. The diabetes drug liraglutide prevents degenerative processes
in a mouse model of Alzheimer's disease. Journal of Neuroscience. 31(17). pp.6587-
6594.
Pan, A. and et. al., 2011. Red meat consumption and risk of type 2 diabetes: 3 cohorts of US
adults and an updated meta-analysis. The American journal of clinical nutrition. 94(4).
pp.1088-1096.
ONLINE
Type 3 Diabetes Symptoms. 2017. [Online]. Available
through<https://www.diabetesselfmanagement.com/blog/type-3-diabetes-symptoms/>.
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