This paper compares the effectiveness of hand washing with soap and water versus alcohol based sanitizers in preventing the spread of infections and microorganisms. The study was conducted in Aden Brookes hospital in United Kingdom. The study involved women with children below the age of 10 years suffering from diarrhea. After the experiment, they swabbed their hands to see if the bacteria has been swiped away. The study showed that, hand wash with water and soap gave the best results whereby the e-coli bacteria was swiped away. In this case, water and soap was seen as the best ingredients for washing hands.