This literature review focuses on the assessment and management of CRE infection in hospital settings. It discusses various studies that highlight the importance of hand hygiene, environmental cleanliness, and other interventions in preventing the spread of multidrug-resistant organisms. The review also explores the impact of colonization pressure and the efficacy of antibiotic therapy for sepsis care. Overall, the findings emphasize the need for cultural practices and timely interventions to effectively manage CRE in healthcare facilities.