Evidence Based Template Fill Up

This template provides a step-by-step guide for developing a search strategy and analyzing literature for evidence based practice. It includes references and limitations for each study reviewed.

Running head: EVIDENCE BASED TEMPLATE FILL UP
Evidence based template fill up
Name of the student:
Name of the university:
Author note:

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EVIDENCE BASED TEMPLATE FILL UP
Critical Literature Review Template
Step 1: Choosing the topic for your review (the topic should relate to your clinical project)
Topic: Evaluation and analysis of the hypoglycaemia in type 1 and type 2 diabetes patients, and the
effect of various physical, social and psychological factors associated with it.
Developing your Topic Question
Use http://latrobe.libguides.com/ebp/Ask to assist you in planning your question and identifying
your key search terms
Population/Patient/Problem
Type 1 and type 2 diabetes patients
Intervention/Issue
The occurrence of hypoglycaemia or nocturnal hypoglycaemia and its proper understanding
Comparative Intervention/Issue (if applicable, describe a comparative or alternative intervention)
Not applicable
Outcome
To successfully and effectively predict, avoid and manage hypoglycaemia attacks
Research Question in Full
Not applicable

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EVIDENCE BASED TEMPLATE FILL UP
Step 2: Developing your search strategy
The second step is to develop the search terms you will use and identify the databases you
will search to find your literature.
Search Plan (write your search terms, including synonyms, truncations).
Population Intervention/Issue Comparison (if
applicable)
Outcome
Type 1 and type 2
diabetes patients
Better prediction and
management of
hypoglycaemia and
nocturnal
hypoglycaemia
Not applicable Better prediction and
management of
hypoglycaemia in
target population.
Search Strategy
Your search strategy using Boolean operators:
A thorough search strategy had been employed involving phrase research and terms, with thorough
usage of Boolean operators such as “AND” and “OR”. At first 778 articles were identified which
was narrowed down using different limiters and the results were narrowed to 15 studies which have
been reviewed in the study.
Limits applied to your search
Articles not written in English, Published in 2012 and before, and Non-Human subject research.
Identify the 2 databases for searching:
Google scholar and COCHRANE

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Step 3: Document your Search
PRISMA Flow Diagram*
Records identified through database
searching (n= 778)
(n = )
Sc
re
en
in
In
cl
ud
ed
Eli
gib
ilit
y
Id
en
tifi
ca
Records after duplicates removed
(n = 145)
Records screened
(n = 145 )
Records excluded
(n = 85)
Full-text articles assessed
for eligibility
(n =60)
Full-text articles excluded,
(n = 45)
Studies included in review
(n = 15)

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EVIDENCE BASED TEMPLATE FILL UP
Step 4: Analyse the Literature
For each of the 15 references you have included in your review, please complete the following.
Reference 1
Reference citation in APA
6th Style
Brown, J. B., Reichert, S. M., Valliere, Y., Webster-Bogaert,
S., Ratzki-Leewing, A., & Harris, S. B. (2018). A
Qualitative Enquiry of Hypoglycemia and the Social
Determinants of Health: The InHypo-DM study,
Canada. Families, Systems, & Health.
https://doi.org/10.1037/fsh0000355
20 words describing the
main focus of the article
The focus of the article is on discovering the relation or effect of the
social determinants of health and type1 or type 2 diabetes and the
probability of hypoglycaemia.
Type of study: quantitative
or qualitative study
descriptive qualitative study
Brief description of study This descriptive qualitative study is based on the InHypo-DM
(Canada) research program. The study uses purposive sampling with
a 30-40 minute semi-structured interview.
Brief description of
findings
Two overarching constituents of the SDoHs were identified,
patients’ socio-economical and psychosocial issue, along with two
social issues poverty and occupation type. The psychosocial issues
identified include life cycle stage (e.g., elderly), social separation,
and status of mental health.

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Brief description of study
limitations
The authors do not outline the limitations of the study although small
sample size and recall bias can be considered as notable limitations.
Reference 2
Reference citation in APA
6th Style
Coca, A., Valencia, A. L., Bustamante, J., Mendiluce, A., &
Floege, J. (2017). Hypoglycemia Following
Intravenous Insulin Plus Glucose For Hyperkalemia in
Patients with Impaired Renal Function. PLoS ONE,
12(2), 1–12.
https://doi.org/10.1371/journal.pone.0172961
20 words describing the
main focus of the article
To determine the incidence of hypoglycemia and severe
hypoglycaemia in a cohort of AKI and non-dialysis dependent CKD
patients that are on intravenous infusion of insulin plus glucose for
treating hyperkalemia.
Type of study: quantitative
or qualitative study
Retrospective cohort study (quantitative)
Brief description of study The authors reviewed charts of all the patients with AKI and the
CKD patients that are non-dialysis dependent that received 10 U of
insulin plus 50 g glucose to manage hyperkalemia from time period
ranging from December 1, 2013 to May 31, 2015 at the Department
of the authors.
Brief description of
findings
Among the one hundred sixty four episodes of hyperkalemia, Eleven
treatments (6.1%) was found to result in hypoglycemia and two

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EVIDENCE BASED TEMPLATE FILL UP
(1.2%) resulted in severe hypoglycemia. A drop of 1.18 ± 1.01
mmol/l was observed in Serum potassium levels.
Brief description of study
limitations
The limitation of the study includes the retrospective design, lack of
ethnic generalizability of results, and measurement bias of insulin
intake.
Reference 3
Reference citation in APA
6th Style
Devries, J. H., Desouza, C., Bellary, S., Unger, J., Hansen, O.
K. H., Zacho, J., & Woo, V. (2018). Achieving
Glycaemic Control without Weight Gain,
Hypoglycaemia, or Gastrointestinal Adverse Events in
Type 2 Diabetes in the Sustain Clinical Trial
Programme. Diabetes, Obesity & Metabolism, 20(10),
2426–2434. https://doi.org/10.1111/dom.13396
20 words describing the
main focus of the article
To determine the potential benefits of semaglutide for type 2
diabetes (T2D) patients to attain glycated haemoglobin (HbA1c)
targets along with evading the range of unwanted outcomes,
including putting on extra weight, hypoglycaemia and
gastrointestinal (GI) adverse effects
Type of study: quantitative
or qualitative study
SUSTAIN clinical trial quantitative.
Brief description of study Data had been extracted from phase IIIa SUSTAIN 1 to 5 clinical
trials. The proportion of participants achieving HbA1c <53

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EVIDENCE BASED TEMPLATE FILL UP
mmol/mol (7.0%) at end of treatment (30 or 56 weeks) without
weight gain had been the Protocol‐specified composite endpoint. The
patients with no severe or considerable blood glucose (BG)‐
confirmed symptomatic hypoglycaemia.
Brief description of
findings
Patients given Semaglutide fared much better in achieving the target
HbA1c in all of the trials, and the unwanted outcomes such as
gaining weight, hypoglycaemia and gastrointestinal (GI) adverse
effects
Brief description of study
limitations
No limitation identified.

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Reference 4
Referenc
e citation
in APA
6th Style
Fang, F., Xiao, H., Li, C., Tian, H., Li, J., Li, Z., & Cheng, X. (2013). Fasting
Glucose Level is Associated with Nocturnal Hypoglycemia in Elderly
Male Patients with Type 2 Diabetes. Aging Male, 16(3), 132–136.
Retrieved from http://search.ebscohost.com/login.aspx?
direct=true&db=s3h&AN=90065484&site=ehost-live
20 words
describin
g the
main
focus of
the
article
The study attempted to identify whether fasting glucose can act as an indicator for the
occurrence of nocturnal hypoglycaemia in elderly male T2DM patients.
Type of
study:
quantitati
ve or
qualitativ
e study
Quantitative study
Brief
descripti
on of
study
291 male T2DM patients receiving continuous glucose monitoring or CGM between
January 2007 and January 2011 was identified and enrolled. the link between nocturnal
hypoglycaemia and fasting glucose was identified by analysing the data, comparing it
with bedtime glucose
Brief Fasting glucose had been identified as a suitable and clinically useful indicator of

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EVIDENCE BASED TEMPLATE FILL UP
descripti
on of
findings
nocturnal hypoglycaemia as observed in elderly male patients suffering from T2DM.
The authors also identified that the nocturnal hypoglycemia risk pointedly increases
when fasting glucose level drops to lower than 6.1 mmol/L.
Brief
descripti
on of
study
limitation
s
No limitation identified.
Reference 5
Reference citation in APA 6th
Style
Gosho, M. (2018). Risk of Hypoglycemia after Concomitant
Use of Antidiabetic, Antihypertensive, and
Antihyperlipidemic Medications: A Database Study.
Journal of Clinical Pharmacology, 58(10), 1324–
1331. https://doi.org/10.1002/jcph.1147
20 words describing the main
focus of the article
The focus of the article had been to explore the clinical drug-drug
interaction and its impact on the occurrence of hypoglycaemia in
diabetes patients.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study The authors have reviewed the JADER and FAERS databases on
suspected ADR incidents and its co-relation with the
hypoglycaemia incidents and the data extracted had been

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EVIDENCE BASED TEMPLATE FILL UP
statistically analysed to arrive at a verdict regarding the link
between drug-drug interaction and occurrence of hypoglycaemia.
Brief description of findings The data findings indicate that the concomitant usage of
sitagliptin/buformin, exenatide/ voglibose, repaglinide/barnidipine,
teneligliptin/barnidipine, teneligliptin/urapidil,
exenatide/candesartan, voglibose/barnidipine,
voglibose/guanabenz, or exenatide/tocopherol, resulting in
combination therapy with potential for causing hypoglycaemia in
the diabetic patients.
Brief description of study
limitations
Lack of information on predisposing risk factors on hypoglycaemia
such as non-compliance to a healthy diet, lifestyle, and alcohol
consumption in the databases.
Reference 6
Reference citation in APA 6th
Style
Korsatko, S., Jensen, L., Brunner, M., Sach, F. S., Tarp, M.
D., Holst, A. G., Pieber, T. R. (2018). Effect of Once‐
Weekly Semaglutide on the Counterregulatory
Response to Hypoglycaemia in People With Type 2
Diabetes: A Randomized, Placebo‐Controlled,
Double‐Blind, Crossover Trial. Diabetes, Obesity &
Metabolism, 20(11), 2565–2573.
https://doi.org/10.1111/dom.13422
20 words describing the main Investigating the impact of semaglutide vs placebo on glucagon

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focus of the article and other counterregulatory hormones while going through
hypoglycaemia for patients with type 2 diabetes (T2D).
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study This double‐blind, placebo‐controlled, single‐centre RCT utilizred
38 male and female samples with 1:1 to 2 12‐week crossover
periods of administering once‐weekly subcutaneous semaglutide or
control, followed by conducting a hypoglycaemic clamp
procedure.
Brief description of findings The data findings indicated that Semaglutide treatment could not
affect the counter-regulatory glucagon response in patients with
T2D during experimental hypoglycaemia.
Brief description of study
limitations
The limitation includes artificial clamp setting in which did not
accurately obtain maximum physiological levels of counter-
regulatory hormones and counter-regulatory response
measurement.
Reference 7
Reference citation in APA 6th
Style
Keiichi Torimoto, Yosuke Okada, Maiko Hajime, Kenichi
Tanaka, & Yoshiya Tanaka. (2018). Risk Factors of
Hypoglycemia in Patients with Type 2 Diabetes
Mellitus: A Study Based on Continuous Glucose
Monitoring. Diabetes Technology & Therapeutics,
20(9), 603–612. https://doi.org/10.1089/dia.2018.0017

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EVIDENCE BASED TEMPLATE FILL UP
20 words describing the main
focus of the article
The study focused on determining the risk factors associated with
hypoglycaemia by the means of continuous glucose monitoring and
glycemic profile of the type two diabetes mellitus patients.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study 294 patients with T2DM receiving inpatient diabetes education was
selected and the mean blood glucose (MBG), coefficient of
variation (CV), mean postprandial glucose excursion, low blood
glucose index (LBGI), and percentage of time with blood glucose
(BG) at <70 mg/dL was carried out. Risk of hypoglycaemia as
measured using transform to Gaussian model
Brief description of findings Results indicated that the patients with low MBG and considerable
fluctuations had been more likely to develop hypoglycaemia, and
these two factors act as considerable assessment factors for
prediction of the disease.
Brief description of study
limitations
Limitations include conducting the research in routine clinical
practice, presence of selection bias, and using only one cut-off
point.
Reference 8
Reference citation in APA 6th
Style
Li, F., Zhang, Y., Zhang, W., Liu, X., Chen, M., Sun, Y., …
Ye, L. (2018). Male Patients with Longstanding Type
2 Diabetes Have a Higher Incidence of Hypoglycemia

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EVIDENCE BASED TEMPLATE FILL UP
Compared with Female Patients. Diabetes Therapy,
9(5), 1969–1977. https://doi.org/10.1007/s13300-018-
0492-3
20 words describing the main
focus of the article
The focus of the research study had been on exploring gender
difference on the risk of hypoglycaemia in T2D patients on
intensive insulin therapy.
Type of study: quantitative
or qualitative study
Quantitative study.
Brief description of study All the selected inpatient participants of the study had to undergo a
standard bread meal test at baseline and underwent a continuous
subcutaneous insulin infusion (CSII) therapy to achieve glycemic
control. Then the participants were given a 4-day retrospective
continuous glucose monitoring (CGM). The primary outcome had
been incidence of hypoglycaemia had been observed by CGM at
the end point
Brief description of findings The result of the study described that male patients with type 2
diabetes for a prolonged period of time led to higher incidence of
hypoglycaemia as compared to female patients that are going
through intensive insulin therapy.
Brief description of study
limitations
Lack of generalizable data due to the study being carried out in a
single city in Northern China, very small sample size, and
observations not being carried out for longer period of time.
Reference 9
Reference citation in APA 6th Murray, P. D., Mckee, B. A., Sainsbury, C. A. R., & Jones,

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EVIDENCE BASED TEMPLATE FILL UP
Style G. C. (2018). Identifying Modifiable Risk Factors to
Reduce Inpatient Hypoglycaemia. Clinical
Pharmacist, 10(8), 251–256.
https://doi.org/10.1211/CP.2018.20205227
20 words describing the main
focus of the article
The focus of the article had been to determine the impact of
modifiable risk factors causing recurrent hypoglycaemia and how
they are generally addressed using specialist advice or not.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study A randomly chosen sample was chosen and data on capillary blood
glucose (CBG) <4mmol/L and diabetes was extracted and analysed
and with comparative analysis of Demographic data, prescribed
medicine and hypoglycaemia treatment.
Brief description of findings The results indicate at advice given to the patients for in-hospital
hypoglycaemia was not frequently followed. Although, proactive
specialist advice triggered by remote CBG review which in turn
could reduce the hypoglycaemia burden.
Brief description of study
limitations
No limitation was addressed in the study by the authors, although
selection and recall bias had not been adjusted in the findings.
Reference 10
Reference citation in APA 6th
Style
Nefs, G., & Pouwer, F. (2018). The Role of Hypoglycemia in
the Burden of Living with Diabetes among Adults

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with Diabetes and Family Members: Results from the
DAWN2 Study in the Netherlands. BMC Public
Health, 18, 1–N.PAG. https://doi.org/10.1186/s12889-
018-5064-y
20 words describing the main
focus of the article
The focus had been to investigate the association between
hypoglycaemic events that are self-reported, the related worrying
and the burden of diabetes among the adults suffering from
diabetes and the family members belonging to Netherlands.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study The study had been a part of DAWN2 study, 412 Dutch adult
diabetics and 86 family members were selected in the study and
completed the questionnaires on burden of living with diabetes,
frequency of hypoglycaemia, worrying, and the different associated
demographic and clinical factors.
Brief description of findings The results indicated that 50% of the diabetics and their family
members experienced diabetes burden and it was associated with
severe worrying about hypoglycaemia, at least occasionally.
Brief description of study
limitations
The limitations include very limited sampling from only
Netherlands which severely underpowered the analysis,
stratification of the analysis missing, and wrong exclusion of
participants.
Reference 11
Reference citation in APA 6th Sonoda, N., Morimoto, A., Ugi, S., Morino, K., Sekine, O.,

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EVIDENCE BASED TEMPLATE FILL UP
Style Nemoto, K., … Miyamatsu, N. (2015). Predictors for
Mild and Severe Hypoglycemia in Insulin-Treated
Japanese Diabetic Patients. PLoS ONE, 10(6), 1–9.
https://doi.org/10.1371/journal.pone.0130584
20 words describing the main
focus of the article
The focus had been to evaluate the predictors, including different
social and lifestyle factors along with factors pertinent to glycemic
control and management for acquiring slight and severe
hypoglycaemia among the Japanese diabetics that are insulin-
treated.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study The study explored 123 insulin-treated diabetic patients where the
mentioned factors were surveyed and then followed up for 6
months. Throughout the follow up period the blood glucose
levels were self-observed.
Brief description of findings The result indicated that the factor pertinent to glycaemic control
and treatment (intensive insulin therapy), social factor (supportive
familial assistance), and a lifestyle factor (drinking) are
comprehensive indicators for slight to severe hypoglycaemia.
Brief description of study
limitations
The limitations include patients of one university hospital, 95%
CI due to few cases, and no specific predictor assessment for
type 1 and type 2 patients.

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EVIDENCE BASED TEMPLATE FILL UP
Reference 12
Reference citation in APA 6th
Style
Takahashi, H., Nishimura, R., Onda, Y., Ando, K., Tsujino,
D., & Utsunomiya, K. (2017). Prediction of Nocturnal
Hypoglycemia Unawareness by Fasting Glucose
Levels or Post-Breakfast Glucose Fluctuations in
Patients with Type 1 Diabetes Receiving Insulin
Degludec: A pilot study. PLoS ONE, 12(7), 1–12.
https://doi.org/10.1371/journal.pone.0177283
20 words describing the main
focus of the article
The focus of the article had been to evaluate the relation between
nocturnal asymptomatic hypoglycaemia and post-breakfast
glucose fluctuations and whether it can act as predictors in
the patients with type 1 diabetes on insulin degludec.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study Patients with type 1 diabetes selected had gone through insulin
degludec underwent CGM assessment. Glycemic variability
indices had been calculated and assessed before and after breakfast.
The patients had been classified to having NAH and not
having it in order to compare the data.
Brief description of findings The results indicate at fasting glucose level lesser than 84
mg/dL had higher chances of predicting NAH incidence of
hypoglycaemia leading to greater fluctuation and steeper post-

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breakfast glucose gradients.
Brief description of study
limitations
The limitations include relatively small sample size, breakfast time
between different patients selected, and lack of generalizability,
viability and transferability of the findings due to this being a pilot
study.
Reference 13
Reference citation in APA 6th
Style
Twigg, S. M., Escalada, J., Stella, P., Merino-Trigo, A.,
Lavalle-Gonzalez, F. J., Cariou, B., & Meneghini, L.
F. (2018). Association of Patient Profile with
Glycemic Control and Hypoglycemia with Insulin
Glargine 300 U/mL in Type 2 Diabetes: A Post Hoc
Patient-Level Meta-Analysis. Diabetes Therapy, 9(5),
2043–2053. https://doi.org/10.1007/s13300-018-0498-
x
20 words describing the main
focus of the article
The focus of the study had been on investigating the association
between baseline patient characteristics and the outcome
characteristics among the T2DM patients that received insulin
glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100),
for 6-months.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study This is a post hoc patient level meta-analysis used data from three
multicenter, randomized, open-label, parallel-group, phase 3a
studies. The end points were described as glycated hemoglobin

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EVIDENCE BASED TEMPLATE FILL UP
(HbA1c), hypoglycemia, body weight change, and insulin dose were
investigated by subgroups: age (< 65 and ≥ 65 years), body mass
index (BMI; < 30 and ≥ 30 kg/m2), age at onset (< 40, 40–50, and >
50 years), and diabetes duration (< 10 and ≥ 10 years).
Brief description of findings The data findings indicate at comparable glycaemic control which
was observed with Gla-300 versus Gla-100, with lesser
hypoglycemia, irrespective of age, BMI, age at onset or diabetes
duration
Brief description of study
limitations
The limitations include post hoc explanatory nature of the analysis
study, the probability of bias in the study, and data measurement5
imbalances.
Reference 14
Referenc
e citation
in APA
6th Style
Watts, S. A. (2018). Best Practice Nursing Management of Nosocomial
Hypoglycemia: Lessons Learned. MEDSURG Nursing, 27(2), 98–102.
Retrieved from http://search.ebscohost.com/login.aspx?
direct=true&db=aph&AN=129092741&site=ehost-live
20 words
describin
g the
main
focus of
the
article
The focus had been on exploring and assessing the nosocomial hypoglycaemia with
best practice nursing management strategies, specifically increase 30-minute
hypoglycemia recheck rate by 50%
Type of Quantitative study

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EVIDENCE BASED TEMPLATE FILL UP
study:
quantitati
ve or
qualitativ
e study
Brief
descripti
on of
study
The authors took the assistance of the PDCA cycle to increase 30-minute
hypoglycemia recheck rate by 50%, by using an electronic data collection
template for hypoglycaemia and a tracking tool. The clinical setting had been
six non-ICU units (two medical and one each surgical, progressive care,
rehabilitation, spinal-cord injury units) with 171 total beds.
Brief
descripti
on of
findings
Not clear from the study.
Brief
descripti
on of
study
limitatio
ns
No9t clear from the study.
Reference 15
Reference citation in APA 6th
Style
Winterstein, A. G., Nakyung Jeon, Staley, B., Xu, D.,
Henriksen, C., & Pflugfelder Lipori, G. (2018).
Development and Validation of An Automated

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Algorithm for Identifying Patients at High Risk for
Drug-Induced Hypoglycemia. American Journal of
Health-System Pharmacy, 75(21), 1714–1728.
https://doi.org/10.2146/ajhp180071
20 words describing the main
focus of the article
The focus of the study had been to explore and develop dynamic
predictive models in order to identify patients at high risk for
hypoglycaemia during anti-hyperglycaemic therapy.
Type of study: quantitative
or qualitative study
Quantitative study
Brief description of study The study included 21,840 patients that received anti-
hyperglycaemic medication on any of the five hospital days in two
of the large hospitals. Lastly, the final models have been internally
validated by replication in 100 bootstrap samples.
Brief description of findings The authors could prove that the prediction models that have been
developed were found to have had excellent discriminative validity
and good calibration. This in turn will allow clinicians to focus on
a select high risk population for which majority of hypoglycaemic
events occur
Brief description of study
limitations
The limitation include selection bias due to selecting purposely
targeted to patients who receive anti-hyperglycaemic treatment,
limited data availability, and small sample size.

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EVIDENCE BASED TEMPLATE FILL UP
Step 6:
Identification of key themes identified in the literature.
Key theme
(descriptio
n)
References that report on theme Summary of the
comments related to
the theme identified
in the reference
Hypoglyc
emia
Associate
d
Autonom
ic Failure
Twigg, S. M., Escalada, J., Stella, P., Merino-Trigo,
A., Lavalle-Gonzalez, F. J., Cariou, B., &
Meneghini, L. F. (2018). Association of Patient
Profile with Glycemic Control and
Hypoglycemia with Insulin Glargine 300 U/mL
in Type 2 Diabetes: A Post Hoc Patient-Level
Meta-Analysis. Diabetes Therapy, 9(5), 2043–
2053. https://doi.org/10.1007/s13300-018-
0498-x
Li, F., Zhang, Y., Zhang, W., Liu, X., Chen, M., Sun,
Y., … Ye, L. (2018). Male Patients with
Longstanding Type 2 Diabetes Have a Higher
Incidence of Hypoglycemia Compared with
Female Patients. Diabetes Therapy, 9(5), 1969–
1977. https://doi.org/10.1007/s13300-018-
0492-3
Korsatko, S., Jensen, L., Brunner, M., Sach, F. S.,
Tarp, M. D., Holst, A. G., Pieber, T. R. (2018).
The HAAF occurs
particularly in the type
1 diabetes patients
whereas occurs only
in certain severe type
2 diabetes cases.
Glucose
counterregulation
effect causes the
Iatrogenic
hypoglycemia.

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EVIDENCE BASED TEMPLATE FILL UP
Effect of Once‐Weekly Semaglutide on the
Counterregulatory Response to Hypoglycaemia
in People With Type 2 Diabetes: A
Randomized, Placebo‐Controlled, Double‐
Blind, Crossover Trial. Diabetes, Obesity &
Metabolism, 20(11), 2565–2573.
https://doi.org/10.1111/dom.13422
Timing of
Procedur
es
Coca, A., Valencia, A. L., Bustamante, J., Mendiluce,
A., & Floege, J. (2017). Hypoglycemia
Following Intravenous Insulin Plus Glucose For
Hyperkalemia in Patients with Impaired Renal
Function. PLoS ONE, 12(2), 1–12.
https://doi.org/10.1371/journal.pone.0172961
The authors have
identified the acute
need for correct
timings for the
procedures for
patients with
diabetes.
Risk
Factors
in
Hypoglyc
emia
Murray, P. D., Mckee, B. A., Sainsbury, C. A. R., &
Jones, G. C. (2018). Identifying Modifiable
Risk Factors to Reduce Inpatient
Hypoglycaemia. Clinical Pharmacist, 10(8),
251–256.
https://doi.org/10.1211/CP.2018.20205227
Sonoda, N., Morimoto, A., Ugi, S., Morino, K., Sekine,
O., Nemoto, K., … Miyamatsu, N. (2015).
Predictors for Mild and Severe Hypoglycemia
in Insulin-Treated Japanese Diabetic Patients.
Several risk factors
identified by the
authors and although
the exact factors that
have been identified
differed in different
studies, the ultimate
factors identified
includes social
factors, psychological
factors and medical

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EVIDENCE BASED TEMPLATE FILL UP
PLoS ONE, 10(6), 1–9.
https://doi.org/10.1371/journal.pone.0130584
Devries, J. H., Desouza, C., Bellary, S., Unger, J.,
Hansen, O. K. H., Zacho, J., & Woo, V. (2018).
Achieving Glycaemic Control without Weight
Gain, Hypoglycaemia, or Gastrointestinal
Adverse Events in Type 2 Diabetes in the
Sustain Clinical Trial Programme. Diabetes,
Obesity & Metabolism, 20(10), 2426–2434.
https://doi.org/10.1111/dom.13396
factors.
Limitatio
ns of
Findings
Takahashi, H., Nishimura, R., Onda, Y., Ando, K.,
Tsujino, D., & Utsunomiya, K. (2017).
Prediction of Nocturnal Hypoglycemia
Unawareness by Fasting Glucose Levels or
Post-Breakfast Glucose Fluctuations in Patients
with Type 1 Diabetes Receiving Insulin
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