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L-dopa Induced Dyskinesia: a Neuropathological Approach

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Added on  2020-04-13

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EXPERIMENT DESEGN1 EXPERIMENT DESIGN 10 Experiment Design Student’s Name University Affiliation of the Basal Ganglia Domains (Limbic, Associative and Sensorimotor) In Induced Dyskinesia Introduction The management of Parkinson’s illness people with a dopamine precursor like the L-dopa boosts the growth of severe changes in motor response as well as involuntary movements referred to as L-dopa induced dyskinesia, a serious complication of L-

L-dopa Induced Dyskinesia: a Neuropathological Approach

   Added on 2020-04-13

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Running head: EXPERIMENT DESEGN 1Experiment DesignStudent’s NameUniversity Affiliation
L-dopa Induced Dyskinesia: a Neuropathological Approach_1
EXPERIMENT DESIGN 2Involvement of the Basal Ganglia Domains (Limbic, Associative and Sensorimotor) InInduced DyskinesiaIntroductionThe management of Parkinson’s illness people with a dopamine precursor like the L-dopa boosts the growth of severe changes in motor response as well as involuntary movements referred to as L-dopa induced dyskinesia, a serious complication of L-dopa therapy associated with Parkinson’s ailment. The true nature of such manifestations can result to experiments concerning the abnormalities of neural function especially in the corticobasal ganglia motor circuit. However, since the modern theory regarding the arrangement of basal ganglia pathways suggests that both the basal ganglia plus the frontal cortex are put in segregated circuits that are parallel, there is a tremendous proof showing the consistence for associative, limbic and sensorimotor domains (Le Jeune et al., 2008).Ideally, research shows that the motor components of a sub thalamic nucleus as well as the dorso lateral tip have a usual terminal activity at the chorea which is of signifance in dystonia. On the other hand, the metabolic activity of the limbic and associative sub thalamic nucleus is impaired in both scenarios. However, the result initially showed that there exists a pathophysiological disparity between dystonia and the L-dopa induced chorea. According to Le Jeune et al., (2008), it can now be hypothesized that can also reflect the association of opposite pathways in a lopa induced dyskinesia hence increasing the likelihood that it as well relates to the unusual processing of the either associative or limbic information.Hence the rationale of this paper is to design an experiment that identifies if or not the modulation of a loop in the basal ganglia can alter the output in other loops in the systematic
L-dopa Induced Dyskinesia: a Neuropathological Approach_2
EXPERIMENT DESIGN 3fashion. The write up also looks at the changes in the 2DG accumulation in associative, sensorimotor plus the limbic domains of the basal ganglia and thalamic nuclei of groups that are not primate. Materials and Methods Used In the ExperimentNineteen female monkeys were put in separate primate rooms under controlled conditions of light, temperature and humidity. Both food as well as water was provided and animal care was being ensured by a registered veterinarian. The experiment was conducted in respect to the European community’s council directive of September for proper care of laboratory animals.For the experiment protocol, the demographic property showed that every methyl phenyl treated animals monkeys showed a comparable phase of lesion as well as different behaviours. Both the control plus the methyl phenyl treated animals corresponds to those animals in the D25 and D0 groups while dsykinetic plus the nondyskinetic species originated from a population of those animals validated earlier. For the later animals, they were created administration of L-dopa twice a day for up to eight months at a modified dose made to give complete reversal of Parkinson’s condition. The animals that contracted serious and reproducible dyskinesia were fivewhile four did not.Regarding the behavioural evaluation, the parkinsonian condition was determined on an animal rating scale using video tape recordings of the animals. After the evaluated a score of zero represented a normal monkey while the score of six and above represented the parkinsonian animal. However, the degree of dyskinesia was measured by use of a dyskinesia disability scale abbreviated as DDS. Zero meant dyskinesia was absent; one meant the condition was mild with
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