This research presents a comprehensive appraisal of structuralist economic theory, focusing on its impact on developing nations. The study highlights the impediments to economic progress and emphasizes the shift towards modern sectors for improved economic health. Factors such as institutional nature, market development, trade specialization, education levels, and ownership structure are examined. The research synthesizes the legacy of structuralist macroeconomics, particularly the Economic Commission for Latin America and the Caribbean (ECLAC) school of thought. It explores the historical development of structuralism, its role in the development of developing countries, and the underlying structural problems they face. The study contributes to understanding the theoretical and methodological foundations of structuralist macroeconomics, with a specific focus on ECLAC analysis.