Efficacy of Omeprazole vs Ranitidine in Managing Peptic Ulcer

This study examines the efficacy of omeprazole vs ranitidine in managing peptic ulcer. It discusses the signs and symptoms of peptic ulcers, the use of omeprazole and ranitidine as treatment options, and their potential side effects. The study concludes that these medications can effectively improve the health outcome of patients with peptic ulcers.

Gastroenterology

Contents
ABSTRACT....................................................................................................................................2
INTRODUCTION...........................................................................................................................2
MAIN BODY..................................................................................................................................3
Efficacy of omeprazole v/s ranitidine in managing peptic ulcer.................................................3
CONCLUSION................................................................................................................................4
REFERENCES................................................................................................................................5
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ABSTRACT
Peptic Ulcers are the frequently faced problem by people all around the world. Long-term
use of non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of serious gastro
duodenal events. In order to minimise the risk related to peptic Ulcer, it has been analysed that
acid-suppressive therapy can be provided so that health outcome of patient is been improved who
are suffering from peptic Ulcer. Literature review of clinical trial has been conducted for the
present research (Zhang and et.al.,2019). It was based on ranitidine 150 mg twice daily to heal
gastro duodenal ulcers and also clinical trial was been done to know the effects of omeprazole
150 mg twice a day. It has also been evaluated that long term treatment was been provided to
patients with omeprazole. Routine laboratory test of patient was being done. It has also been
analyzed that ranitidine and omeprazole has shown an increasing healing effect during the time
of clinical trials. It has been analyzed that these inflammatory drugs can be taken for treatment of
peptic Ulcer as the rate related to healing by making use of these drugs has gradually increased.
The healing rate was also been analyzed at the specific time. It has also been evaluated from the
research that peptic ulcer can reduce down the health outcome of patient. In worsening condition,
it is really necessary for an individual to consult health care professional so that their health
outcome can be improved.
INTRODUCTION
Peptic Ulcers are basically the sores which are been grown up in the lining of stomach,
lower oesophagus or small intestine. The main reason behind formation of these sores are that
they are a result of inflammation which has been caused by bacteria H. pylori. This health related
disease can be seen among most of the people and is a global problem. It can be considered as a
common health disease. There are various different factors because of which this disease can be
developed (Okon and Egesie, 2017). Mostly peptic ulcer is been faced by those people who are
highly involved consuming alcohol or liquor on regular basis. Peptic Ulcer can impact the
quality of life of patient and can also reduce down their well-being. It has also been evaluated
that people with stomach cancer can also face problem of peptic Ulcer. In order to overcome this
problem there are various inflammatory drugs which are been developed so that health outcome
of an individual suffering from peptic ulcer can be improved. It has also been analysed that
people who are been involved in making use of aspirin and ibuprofen frequently can also go
through this disease. High usage of this can increase risk of peptic ulcer. There are various signs
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and symptoms that are been related to this disease. It includes that patient can have a feeling of
burning in lower abdominal part. In order to cure the problem of peptic ulcerOmeprazole is used
to treat certain stomach and oesophagus problems. This can work effectively as it assist patient in
reducing down the acid level in stomach. It will also protect the esophagus from further damage,
so patient can take this type of inflammatory disease. Ranitidine can also be used for treating
peptic Ulcers in stomach, the dosage of drug must be prescribed by health care professional.
MAIN BODY
Efficacy of omeprazole v/s ranitidine in managing peptic ulcer.
Signs and symptoms of Peptic ulcers
In the view point of Sharma and et.al.,(2017)there are various signs and symptoms of
peptic ulcers. It has been analysed that the patient who is at risk of suffering from this disease
needs to have knowledge of early signs and symptoms related to it. This will assist patient in
enhancing health outcome of patient and also the quality of life of patient will be improved. It
has been analysed that there is an increase prevalence of peptic ulcer in the society. Drugs can be
considered as sensitive for radical cure. This is being formed inside the stomach because of
formation of bacteria known as pylori. Symptoms related to disease can be loss in weight and
appetite. This is majorly been cause to those people who have been involved in consuming liquor
and smoking cigars on regular basis. It can also be cause to those who are going through problem
of stomach cancer reducing the health outcome of patient. It has also been analysed that small
peptic ulcers may not produce any type of symptom at an early level (Shim and Kim, 2017).
After some time patient can face problem of boring in abdominal. Various inflammatory
drugs can be taken so that health outcome of patient suffering from peptic ulcer can be improved.
Patient can also face various signs and symptoms such as nausea, vomiting, unexplained weight
loss, indigestion (Chung and Shelat, 2017). Peptic ulcer can also reduce down the health
outcome of patient and also lay negative impact on quality of life of people. There are various
test which can assist health care professional in diagnosing peptic ulcer. It has been analysed that
care providers can be engaged in making patient go through upper endoscopy. This test is been
recommended to those patients who are at higher risk of having peptic ulcer and already
suffering from problem like stomach cancer. In upper endoscopy long tube is been inserted down
the throat in order to analyse whether the patient is been suffering from peptic ulcer or not.
People who are at higher risk of getting this disease is above the age of 45. The treatment of
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peptic ulcer is been related and based on underlying cause of disease. It has been analysed that
various inflammatory drugs can also been given to patients in order to cure peptic ulcer. Health
care professionals are been involved in providing patients with drugs like omeprazole and
ranitidine. These drugs can be given in order to enhance the health outcome of patient (Lanas
and Chan, 2017).
Efficacy of drugs like omeprazole: In the context of peptic ulcer which causes infection and
can lead to severity needs to be treated in an effective and in a timely manner. If it is not treated
with appropriate medications and in a timely manner then it can cause several other health
problems and affect overall health of patients. So some medications have been identified which
is being majorly prescribed to patients with peptic ulcer such as: omeprazole. There are some
ways of using this oral medicine such as:
Uses: This medicine is mainly prescribed to patients with peptic ulcer in order to treat certain
stomach problems. One of the main use of this medicine is it decreases acid in stomach of
patients which stomach makes and due to increasing extent of this acid it creates problems like
ulcers. As we all know that ulcers in stomach create several problems like heartburn, difficulties
in swallowing as well as cough. And this medicine does not only help in decreasing ulcers by
decreasing level of acids but also helps people in treating and healing damages which already
have happened in stomach due to ulcers and also prevent them against cancer of esophagus. In
the context of medical language it can be said that Omeprazole belongs to a class of drugs known
as proton pump inhibitors (Sharma and et.al., 2017).
People can use at their own and self treat their ulcers, heart burn by using this medicines if they have
knowledge of making use of this drug, in appropriate quantity and all. It is stated that it takes around
1-4 days in treating ulcers and heart burn but it does not prevent patients against heart burn in a
complete manner. Along with this medication, people require taking care of themselves by having
nutritional food with less species and light food. Because it is stated that food which contains heavy
species can lead to heartburn and ulcers. So, it can be said that self management and self care is also
important in treating this problem. For over-the-counter products and if patients are treating
themselves at their own then they must require reading and following package instructions. It is also
stated that different brand uses different ingredients so, it is important checking the whole details
given on packaging before using otherwise people may have side effects.
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In addition, it is stated that if patient take this medicine after prescription that time also they require
reading leaflet available from pharmacist and if they are taking the over-the-counter product to self-
treat then they must require reading whole instructions and ingredients used in it. Patients are
prescribed and suggested to take this medicine by mouth as directed, once daily before the meal.
Dosage and length of treatment is mainly based on the nature and the extent of the disease or medical
condition. If patients are taking it as their own or after prescription then they need to avoid increasing
or decreasing dosage than directed. Not crushing, chewing or delaying in taking this medicine is other
main factor needs to be considered as it can increases risk and side effects.
The right way of taking this medicine is placing on the tongue and let it dissolve and it is also
suggested that if people use the disintegrating delayed release tablets, use dry hands to handle the
tablets then they need to use dry hands in order to handle tablets. As per the nature of disease and as
directed people can take antacids along with this medicine if required. For better and effective
outcomes people require taking this on the same time each day and also regularly. But it is also stated
that if people are taking at their own or self treating then they should not take this more than14 days
unless directed by doctor. (Efficacy of Omeprazole, 2020). If they find any difficulties and worse
situations after taking this then people require visiting immediately y to doctor.
There are some sides effects related to this medicine and people must have knowledge of all these side
effects if they are taking this medicine without prescription, at their own or if they are self treating
because the wrong direction and the wrong way may lead to several problems and some of discussed
side effects. Some side effects associated with this medicine are:
Back and stomach pain: It is stated that if patients do not take this medicine in the right manner
then it may lead to stomach ache. In some cases after prescription and taking medicine in an
appropriate manner also, patients may feel this problem and that time they require consulting
with doctor for treating themselves against this pain and ulcers as well.
Allergies: It is other main common side effects which is associated to this omeprazole. People
may feel some blisters on their body and rashes as well and at that time also they require
consulting with doctor. In such cases doctors changes medicine and dosage after analysing the
whole case and problems.
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Muscle ache, rashes, painful urination, discomfort, illness are some other side effects if people
do not take precautions seriously and o not follow all instructions in an effective manner.
For better usage and preventing against side effects like diarrhoea and others discussed above
patients require taking this in an effective manner by reading all instructions and ingredients
because there are some people who are allergenic to some ingredients used in medicine. So, by
reading all guidelines and information and also after prescribing by doctors , taking precautions
they can prevent themselves. They can also treat this heart burn and peptic ulcer problem within
14 days if taken as directed (Zhang and et.al., 2017).
So, overall from the above discussed usage and side effects it can be said that this
medicine plays an important role in treating people with peptic ulcers in within 14 days if taken
properly. And after prescribing from doctors, people can improve their overall health by
consulting other causes of this problem and taking extra care of it.
Effects of drugs like ranitidine
Impact of peptic ulcers on health and wellbeing of patient
CONCLUSION
From the above study it has been summarised that peptic ulcer can reduce down health
outcome of patients. Peptic ulcer can also reduce down the health outcome of patient and also lay
negative impact on quality of life of people. There are various test which can assist health care
professional in diagnosing peptic ulcer. It has been analysed that care providers can be engaged
in making patient go through upper endoscopy. In order to treat this disease various type of
medication has been provided by health care professional in order to enhance health outcome of
patient. This has assisted the care providers in enhancing well being and quality of life of those
patients who have been suffering from peptic ulcer. It has also been analysed and evaluated from
the report that most of the time peptic ulcer has been faced by those patients who have been
highly involved consuming alcohol or liquor on regular basis. Peptic It has also been summarised
from the report that Ulcer has affected the quality of life of patient and can also reduce down
their well-being. It has also been analysed that there are various signs and symptoms that needs
to be analysed by patient so that they can stop ulcer to grow. Omeprazole is the medication that
has been considered in order to cure peptic ulcer. This medication has been used in order to cure
the problem related to flow of acids backward from the stomach which causes heartburns. The
medication has been taken patients when prescribed by health care professionals. Evidence has
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also provided that these capsules are really effective in reducing down the level of acid inside the
stomach, so they have been provide by health care professionals to treat patients who have been
suffering from peptic ulcers. It has also been summarized that these medications can also have
several side effects like they have cause effects such a headache, vomiting, nausea. Before
consuming these medications patients has been engaged in telling health care professionals about
whether they have been allergic to certain type certain type of content that has been included in
the medicine such as dexlansoprazole (Dexilant). This has assisted the care provider in
enhancing well being of patients who have been suffering from this chronic disease. It has also
been analyzed from the report that some of the side effects of this medication can also be serious
like patient can face severe diarrhea with watery stools stomach pain,, or fever that does not go
away. In this condition health care professional must be consulted so that health outcome of
patient can be improved. It has also been analyzed from the report that Routine laboratory test of
patient was being done. It has also been analyzed that ranitidine and omeprazole has shown an
increasing healing effect during the time of clinical trials. Other type of medication can also be
given in order to treat ulcer. It is really necessary that patients have knowledge related to early
signs and symptoms of disease.
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REFERENCES
Books and Journals
Shim, Y.K. and Kim, N., 2017.The effect of H2 receptor antagonist in acid inhibition and its
clinical efficacy. The Korean Journal of Gastroenterology, 70(1), pp.4-12.
Okon, J.E. and Egesie, G.U., 2017. Gastrin, Histamine Prostaglandin: Indicators for assessing
efficacy of cimetidine, Omeprazole and Ranitidine in Gastric Ulcer Treatment. Janaki
Medical College Journal of Medical Science, 5(2), pp.5-12.
Zhang, J. and et.al.,2019. Standard-dose proton pump inhibitors in the initial non-eradication
treatment of duodenal ulcer: systematic review, network meta-analysis, and cost-
effectiveness analysis. Frontiers in pharmacology, 9, p.1512.
Sharma, T. and et.al.,2017. Efficacy of aspirin (325 mg)+ omeprazole (40 mg) in treating
coronary artery disease. Expert Opinion on Pharmacotherapy, 18(1), pp.123-131.
Lanas, A. and Chan, F.K., 2017. Peptic ulcer disease. The Lancet, 390(10094), pp.613-624.
Chung, K.T. and Shelat, V.G., 2017. Perforated peptic ulcer-an update. World journal of
gastrointestinal surgery, 9(1), p.1.
Sharma, T. and et.al., 2017. Efficacy of aspirin (325 mg)+ omeprazole (40 mg) in treating
coronary artery disease. Expert Opinion on Pharmacotherapy, 18(1), pp.123-131.
Zhang, J.L. and et.al., 2017. Effects of omeprazole in improving concurrent chemoradiotherapy
efficacy in rectal cancer. World journal of gastroenterology, 23(14), p.2575.
ONLINE
Efficacy of Omeprazole. 2020. Online Available through: <
https://www.webmd.com/drugs/2/drug-3766-2250/omeprazole-oral/omeprazole-delayed-
release-tablet-oral/details.>
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