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Gene Environment Interaction Analysis of Serotonin System

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Added on  2020-05-28

Gene Environment Interaction Analysis of Serotonin System

   Added on 2020-05-28

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Literature Review: Adolescent depression
Gene Environment Interaction Analysis of Serotonin System_1
ContentsArticle 1:..........................................................................................................................................2Article 2:..........................................................................................................................................2Article 3:..........................................................................................................................................3Article 4:..........................................................................................................................................4Article 5:..........................................................................................................................................5
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Article 1:Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., ... & Craig, I. W. (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression.Molecular psychiatry,9(10), 908-915.The analysis of the article is mainly from a study related to the environmental interactions of the genes with the depression of adolescent. With this, the research is mainly in between the individual vulnerability and environmental stress in adolescent. According to the research, the monoamine hypothesis has been considered as the biological basis of depression which is then reflected through antidepressants. It directly works on the system with serotonin reuptake inhibitors. It focuses on the environmental risks groups where sex is the significant predictor for the people who are facing the problem of depression. With this, the major influence of the genes and the environmental changes has brought genetic variance. The molecular genetic work tends too target and identify the role under the risks for depression, where the predominant theory is based on the depression that is done through the hypothesis of monoamine. The child specific risks certainly include the factors which include the life events or the problems in the family which leads to the problem of depression.Article 2:Lewis, G., Collishaw, S., Thapar, A., & Harold, G. T. (2014). Parent–child hostility and child and adolescent depression symptoms: the direction of effects, role of genetic factors and gender.European child & adolescent psychiatry,23(5), 317-327.The article discusses the identification of the environmental risks factors that lead to the problemof depression. The adolescence is the peak period for the emergence of depression and the
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