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Adeno, Associated Virus Gene Therapy Of Hemophilia A INTRODUCTION Gene therapy is the process of new genes intocellsforrestoringoraddinggene expression. The main objective of doing this is to treat a person from many diseases. In this process, generally a mutated gene is being replaced by with DNA that encodes a functionalcopy.Atherapeuticdrugis generated by encoding DNA. Virus Gene Therapy of Haemophilia DiseaseCurrent and Emerging Gene Therapies Various studies state that haemophilia can be treated permanently by gene therapy. In a case adeno, associated virus was used to deliveracodon-optimizedversionof human factor VIII gene. The vector was administered into three different cohorts of patients such as low, highand medium dosage groups. This therapy was managed and it has no adverse reactions because of the treatment. Bleeding decreases after the gene therapy and this allows cessation of prophylactic FVIII treatments. REFERENCES Haemophilia is an X linked disorder that is characterizedbycontinuousbleedingin joints and muscles and increase in risk for intracranial hernorrhage. The main cause of this disease is deficiency of the functional plasmaclottingfactor VIII. Thisresults frommutationsintheFVIIIgene. The Adenoassociatedvirusesofparvovirus family are small viruses that have a genome of single stranded DNA. Such kind of virus is used for inserting genetic material at a particularsiteonchromosomewitha certainty of hundred percent. On the other hand there are few disadvantages of use of adeno-associated virus is that it includes small amount of DNA it is capable to carry and produce. Current and Emerging Gene Therapies Virus Gene Therapy of Haemophilia Disease Green, D. and Ludlam, C.A., 2013.Fast Facts: Bleeding Disorders. Karger Medical and Scientific Publishers. Primer, A., 2012. Immunotherapy. Liu, D., 2017. Hemophilia and Learning to Love Science.