Ask a question from expert

Ask now

BIO 490- Genomics of Infectious Disease Report

8 Pages2297 Words256 Views
   

Central Connecticut State University

   

GENOMICS OF INFECTIOUS DISEASE (BIO 490)

   

Added on  2020-03-04

About This Document

The below document discusses the Genomics of infectious diseases. It also discusses the Tracking of infectious diseases by Genomic  Sequence data, the Action of drugs in controlling infections of H.I.V, T.B, the Molecular basis of organism drug resistance in some diseases, and the Application of genome sequence in infectious diseases.

BIO 490- Genomics of Infectious Disease Report

   

Central Connecticut State University

   

GENOMICS OF INFECTIOUS DISEASE (BIO 490)

   Added on 2020-03-04

BookmarkShareRelated Documents
Running head: GENOMICS OF INFECTIOUS DISEASEGenomics of Infectious DiseaseName of the studentName of the UniversityAuthor’s note
BIO 490- Genomics of Infectious Disease Report_1
1GENOMICS OF INFECTIOUS DISEASETable of ContentsTracking of infectious disease by Genomic Sequence data.........................................................2Action of drugs in controlling infections of H.I.V, T.B...................................................................2Molecular basis of organism drug resistance in some diseases...................................................3Application of genome sequence in infectious disease................................................................4References..................................................................................................................................6
BIO 490- Genomics of Infectious Disease Report_2
2GENOMICS OF INFECTIOUS DISEASE Tracking of infectious disease by Genomic Sequence data With the advent of the revolution of the next generation whole genome sequencing of widevarieties of a pathogen, the molecular diagnostics of infections has made an outbreak. The nextgeneration sequencing uses the DNA sequence and determines the data of information in acomplete run. These data can be used to understand the virulence, cross-infections and themode of infections in the pathogens. The next generation sequencing platforms like theMiseq( Illumina) and Ion PGM are mainly used to generate the sequences of the requiredpathogens. The sequencing data would then be analyzed by the software tools for theoptimization. The sequence analysis will help to find out the genetic conditions of the pathogensduring infections. The epidemiological monitoring of the cross infection in the pathogens can bestudied by studying genome sequence data (1). The genome sequence data will also give thephylogenetic relationship among the similar group of pathogens and find the mutation in thegenes that have lead to the cross infection or the infection in the host. The metabolic changesand the housekeeping functions can be traced with the use of the data. Thus NGS or the nextgeneration sequence that will involve the comparison of huge data of micro organisms mayshed some light n the evolution and the population genetics of the disease. By comparingseveral samples from the population one can easily identify the root change that causes tocross infection in a population. The real reason behind the infections and the transmission of thedisease can be understood through the genome data of the pathogens. Genome sequences willidentify the phenotypic and the genotypic changes of the pathogens that confirm with thedynamics of infection. Thus this will help to develop a more strategic plan for the prevention,treatment, and designing of vaccines. Haemophilus is the first pathogen whose genome wassequenced. This has identified that in human disease A and B subtypes are defined by thehemagglutanin and neuraminidase which has significant roles in the novel therapeutics anddiagnosis. Limitation in Whole genome sequencing is that it can give information of thesequence of one pathogen at one time (2). Action of drugs in controlling infections of H.I.V, T.B The virus of Human immunodeficiency spreads in an alarming manner. Despite such aspread of the disease, the countries have now adapted the drugs that have hugely controlledthe transmission. The virus in H.I.V attacks the CD4 cells, T cells. Thus the number of T cellsget lowered and the make the immune system harder to guard against the diseases. The main
BIO 490- Genomics of Infectious Disease Report_3

End of preview

Want to access all the pages? Upload your documents or become a member.

Related Documents
Communicable Disease Control : Report
|10
|2209
|33

Era of Whole-Genome Sequencing
|9
|11895
|16

Disease and Body Defence: Categories, Transmission, Worldwide Importance, Tuberculosis and Antibiotic Treatment
|13
|1048
|475

Methods and Techniques in Molecular Biology
|10
|2412
|18

Identification and Characterisation of Prohibitin-2 as a Receptor for Dengue Virus in Insect Cell
|5
|2790
|379

HIV-AIDS: A Retroviral Disease and Management
|24
|1565
|82