Global Vaccine Safety Blueprint - PDF

Assessment template
Question 1
Question 1A
Question: To what extent does the immunization pattern prove to be deleterious for the growing
children, in comparison to the children who do not receive vaccination interventions?
Rationale: The research question advocates the requirement of undertaking comparative analysis
between the wellness outcomes/adverse events experienced by the immunized children and the children
whose parents do not enrol themselves in immunization programs. Indeed, the research objective
substantiates the need to conduct a systematic analysis of the safety profiles of various immunization
interventions with the objective of determining the extent of beneficial outcomes in comparison to the
patient solicited/unsolicited adversities.
Question 1B:
Source of information Type of
information
Australian Government Department of Health website
(http://www.health.nsw.gov.au/Infectious/whoopingcough/Pages/Identify-Protect-
Prevent.aspx)
Whooping
Cough
Protection
Parameters
Australian Government Department of Health Immunization Handbook
(http://immunise.health.gov.au/internet/immunise/publishing.nsf/Content
/7B28E87511E08905CA257D4D001DB1F8/$File/Aus-Imm-Handbook.pdf)
Epidemiology,
wellness
outcomes and
adverse events
following

immunization
WHO
(http://apps.who.int/iris/bitstream/handle/10665/70854/WHO_IVB_12.04_eng.pdf;jsessionid
=
F674E9DEEADAF2C3F5EDD3283F0A1949?sequence=1)
Global vaccine
safety blueprint
Question 1C:
Keyword Search term for Boolean ‘or”
1 “Immunization” AND “Barriers”
AND “Adversities” AND “Safety”
Vaccination
2 “Immunization” AND “Outcomes”
OR “Wellness”
Vaccination, Results
3 “Vaccination” AND “Safety” Immunization, Health
4 “Vaccination” AND “Adverse”
“Reactions”
Immunization, Allergy
5 “Immunization”, AND “Children”,
AND “anti-vaccination”, AND
“diseases”, AND “health”
Vaccination, Manifestations, Wellness
Question 1D:
The absence of retrieval of satisfactory quantity of qualitative articles will substantiate the
requirement of changing the search parameters for identifying the articles of interest. The utilization
of more dynamic and relevant search terms might suffice the requirement of acquiring significant
content related to the study question. Alternatively, modification in the research question or
expanding the scope of research parameters will increase the exploratory dimensions that might assist
in acquiring the relevant systematic studies related to the immunization interventions and their
associated outcomes. For example, search terms could merely focus on exploring patient adversities
that emanate from the administration of a range of immunization interventions in children of age
group 0-10 years. Similarly, another search strategy could effectively articulate facts regarding the
safety parameters related to various vaccine interventions (including HPV and hepatitis B) for the

selected patients. The exploration of disease-based articles in the context of immunization
requirement and associated outcomes will indeed widen the scope of research and lead to the
acquisition of desirable articles in the shortest timeframe.

Question 2
Table 1. Meta-analysis (+/- systematic review)
Full reference:
Nursing
Stassijns, J, Bollaerts, K, Baay, M & Verstraeten, T 2016, 'A systematic review and meta-analysis on the safety of newly adjuvanted
vaccines among children', Vaccine, vol 34, no. 6, pp. 714-722, <https://www.ncbi.nlm.nih.gov/pubmed/26740250>.
Search strategy Vaccine safety data from a multitude of published clinical studies was systematically explored by the research professionals. The
vaccines of interest included the immunostimulants AS02 and AS01.
Inclusion/exclusion criteria Inclusion Parameters
1. Children of less than 10 years of ages
2. Children with eligibility for receiving adjuvanted vaccines
3. Children with no previous record of allergy or adverse reactions in response to the administration of adjuvanted vaccines
Exclusion Criteria
1. Children with pre-existing vaccine-related allergy or toxicity profile
2. Children affected with disease pandemic against which the vaccine administration was recommended