Dysfunctional HDL and Atherosclerotic Cardiovascular Disease

Running head:HEALTHCARE SYSTEMS
HEALTHCARE SYSTEMS
Name of the student
Name of the university
Author note

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Part 1
Article Comparison Table
Criteria Article One Article Two
Citation Jaiswal, S., Natarajan, P., Silver,
A. J., Gibson, C. J., Bick, A. G.,
Shvartz, E., ... & Baber, U. (2017).
Clonal hematopoiesis and risk of
atherosclerotic cardiovascular
disease. New England Journal of
Medicine, 377(2), 111-121.
Rosenson, R. S., Brewer
Jr, H. B., Ansell, B. J.,
Barter, P., Chapman, M.
J., Heinecke, J. W., ... &
Webb, N. R. (2016).
Dysfunctional HDL and
atherosclerotic
cardiovascular
disease. Nature reviews
cardiology, 13(1), 48.
Content Summary
Craft a 100-150 word
summary of the article
Clonal indeterminate potential
hematopoiesis (CHIP) which is
characterized as the presence of an
enlarged somatic blood –cell lone
in individuals with no other
hematological abnormalities, is
associate with increased risk of
hematological cancer. The
presence of CHIP in peripheral
blood cells has been associated
with almost a doubling of the risk
of coronary heart disease in
HDL protects against
atherosclerosis by means
of multiple mechanisms
including endothelial
dysfunction
improvement, removal of
excess cholesterol from
the macrophage and
antioxidant, anti-
apoptotic and anti-
inflammatory effects.
DDL loses its

2HEALTHCARE SYSTEMS
humans and increased
atherosclerosis in mice. Clonal
hematopoiesis may be a modifiable
risk factor, perhaps by using
cholesterol-lowering drugs or by
targeting particular inflammatory
tracts.
atheroprotective
properties under specific
circumstances, resulting
in the development of
dysfunctional HDL
particles. These particles
increase proinflammatory
signals and decrease the
cholesterol efflux from
macrophage by the ATP-
binding cassette
transporter A1.
Research Methods
Describe the methods used,
including tools, systems, etc.
To evaluate the early onset of
myocardial infarction or the
presence of CHIP – the whole-
exome sequencing method was
used.
The fluorescence-based
assay
The focus of the
Research or Study
Describe the design of the
relevant research or study in
the article.
Whole exome sequencing was
used to identify the presence of
CHIP in peripheral blood cells and
correlated it with coronary heart
disease using samples from four
case-control studies that included
4726 participates with coronary
heart disease and 3529 controls. To
The macrophage
cholesterol efflux
capacity measurements
are done using standards
labeled cholesterol and
fluorescent BODIPY-
cholesterol although
fluorescence-based assay