The History, Ethics, and Impact of HeLa Cells on Cancer Research
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This essay explores the history, science, and biology of HeLa cells, their uses in cancer research, and their contributions to medical breakthroughs. It also discusses the ethical issues surrounding the use of HeLa cells in biomedical research.
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The history ethics and impact of HeLa Cells on Cancer Research
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“The history ethics and impact of HeLa Cells on Cancer Research” INTRODUCTION Hella Cells can be understood as immortal cell line used within scientific research, where it is oldest human cell line and derived from cervical cancer cells. The cells found on 8 February, 1951 from Henrietta lack, 31 year old African American mother who died of cancer. Essay will discuss details of usage within cell , where it plays crucialrole in cancer research method where tests further has been found to be highly significant essential cell. It is also found to be also specifically essential where Hella cells are used to study effects of toxins, drugs and hormones, viruses within growth of cancer cells without experimenting among humans. Essay will also determine relevant history on data cells, relevant aspects connected to further determine specific working innovation with changing time period and also functionally bring keen technical knowledge related to science behind Hella cells (Rahman, 2021) Discussion Hella cells have been found to be highly effective tool, for growing large amounts of poliovirus, where high amount of virus can be grown in Hela cells that allow scientists to better understand virus. The high amount of virus has been used within science, biology of Hella cells where it understands virus which further infects cells and causes diseases further. The Hella Cells proliferate abnormally rapidly, where it is compared to other cancer cells where research further has been found to be relevant and essentially forming stronger base for research within scientific research. It has been also found that immortality significantly focuses to bring on immortality within its existence, on which it has been critically found to be having huge history. Uses, science and biology of HeLa Cells Scientists discover that Hella cells are fund to be effective tool, for growing large amount of poliovirus, based on polio disease within beginning where high amount of virus allows scientist to significantly understand infection caused with virus. Hella cells have various immortal cell lines, where some of them hold normal cell lines and immortalised cells which are known to be cancerous cells. Origins of some immortal cell lines are Hella human cells and are naturally known to be occurring cancers among people (Rahman, 2021).The Hella Cells have been important for scientific discovery within last century and was the first
immortal human cell line, which assisted in the treatment of Henrietta by Jhon Hopkins researcher Dr. George Gey in 1951. Although they were the first cells and multiplied within lab setting, on which the scientist offered cells freely and widely for scientific research. Over past recent years, cell line has also contributed within modern biology science to many medical breakthroughs over research on the effects of zero gravity based on development of polio and covid-19 vaccines over the study of Leukaemia, AIDS virus and cancer worldwide treatments. It has also supported significantly over advances within fields of modern research within recent time period on which cells were further isolated (Xie and et.al, 2021). Important scientific discoveries of the last century was the first immortal human cell line, where treatment of cancer has been structured up with huge evolvement in Hella cells. The scientific usage of Hella cells has been also found to be helpful within treatment of Polio, improved cell culture practices, chromosome counting which have been considered as three most major contributions within field of science. Hella cells have also contributed in study of effects of toxins, drugs where hormones, viruses have been significantly evolving in growth of cancer cells without experimenting among humans directly. It can be understood that viruses work, played crucial role for development of new vaccines within advanced medical science. In 1952, Hella cells became first human cell that could grow and divide endlessly in laboratory where it further lead to scientists where cells were found to immortal and highly essential in specific advanced research in medical treatments (Nott, 2021). The immortality of cells has continued to have assist in biomedical research among medicines, and endure usage of Hella cells in biomedical research through significant timeline of events within researches. It can be analysed that events of research further has been increased, in more than 110,00 scientific publications rapidly among advanced medical and biological treatments among research parameters. In 1953, laying ground work for Polio Vaccine started which has been found to be one of the most significant research within year. It can be also analysed that within year of 1956, understanding effects of X-rays on human cells has been also crucial research behind fundamental usage of Hella cells. Further developing cancer research methods and medical science treatments have been actively found to be also one of the major contributions by Hella cells where it is highly reliable method in latest medical science (Yu, Yang and Najafi, 2021). History and impact of HeLa in treatments The study of potential treatment benefits of drug called within Hydroxyurea against blood cancers and cell anaemia, on which it has been found to be applied in cancerous cells
which also further enabled to slow down their spread. It is also shown within scientific aspects that Hydroxyurea helps to prevent mis-shaping among red blood cells, which is also found to be one of the major aspect responsible for sickle cell anaemia (Pourhanifeh and et.al, 2021). The history of Hella Cells can be understood form year 1951, where Henrietta Lacks, 31-year-old American African women went to hospital for being treated on cervical cancer. It has been also found useful within research due to specific abilities, for continuous growth and divide within laboratory. It can be also analysed that immortal cells were later also found as Hella, which have been named after two initial words of Lady Henrietta Lacks. It has been also found that untimely death within year 1952, the cells further have been used to create significant understanding on fundamentals about human health and diseases. Some of the advanced research involving Hella cells also served as underpinning several Novel prize- winning discoveries further extended towards advanced medical science. The significant contribution of Hella Cells has been found to be also strong, where presence has been identified as major aspect where it further lead to certain cervical cancers. It has also been found to be achieved Nobel Prize in 2008. The cells are cancerous, which due to their characteristic togrow fast can be found contaminated and overtake other cell cultures related with Henrietta Lacks which had syphilis. It has also further resulted within aggressive growth of cancer due to weakened immune system among humans significantly. Hella Cells began to compete with cells in developed human immortal cells, which overtook and replaced cellsbecause of aggressivecancer.Crosscontaminationhasbeenfound to be also significantly diverse, on diminishing reproducibility of data which is also important to create validation within findings.This has been also found to be also significant aspect, where validating findings and data holds huge importance for strengthened vision rise based on competent pathways diversely (Davenport and et.al, 2021). Furthermore, advancing understanding of HIV infection, scientists discover that Hela cells are not infected by HIV where researchers gain significant understanding of infection works rapidly.The knowledge later also facilitated within drug development, which further aimed at limiting spread of HIV in body on which Hella Cells have huge history. Nationalinstituteof healthproviderswith agreementbased on descendantsof Henrietta which allowed biomedical researchers which had controlled access to whole genome data of Hela Cells. The data of cells have valuable reference tool, where study of
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research behind the fundamental utilisation of developed treatments had further extended functional rise within authenticity. The Hela cells has significant importance related to ethical usage where ethics related to informed consent, privacy and commercialization within collection has been competently used on. Ethics plays strong role in using Hela Cells, where collection along with storage and research further developed usage of significant details about informed consent, overnight large-scale data sharing privacy and confidentiality within usage in medical science. Success of further utilisation of Hela Cells, depends on acceptability to patients and public, building and maintaining strong support, trust and transparency within productive scientific usage of cells. Story of Henrietta Lacks, within creation of Hela cells has been found to be catalyst within policy changes, based on major regulatory policies among US for informed consent within biospecimen research further among functional arenas.It reflects on role of Hela controversy where as per public opinion and general development of biospecimen research policy, need for informed consent approaches further helped in creating realistic aspirations fundamentally. Balanced view of autonomy within expanded ethical framework further plays keen role in analysing functional utilisation towards Hela cells usage in Bio medical research significantly. The ethics of using HeLa Cells Hela cells had significant and lasting impact on huge parameters among ideas, where areas regarding disease understanding, benefitting millions of patients around world rapidly. Henrietta Lacks had refused physicians right to collect and use tissues, where contemplating potential future breakthroughs have hindered data protection resulting power that patient’s dint had right to use cells in research (Chen and et.al, 2022). The women behind cells revolutionized usage in medical field helped polio vaccine, and numerous cancer treatments based on impact of Hela cells, within ethical issues related to informed consent in medical practices within recent time.The immortal life of Henrietta Lacks focuses on many issues where, this has been found to be one of the most competent advanced ethical factors crucial for further extensive research. It has been also identified that ethical issues associated within usage of Hela cells brought significant public attention about number of ethical issues in biomedical research within dynamic advanced time period rapidly. It includes role of informedconsent,privacyandcommercialisationwithincollectionandusageof dissemination among biospecimens. Over the past several decades, cell has been found to be highly influential in medical breakthroughs and researches which has created significant effect on development of polio
vaccine, and study of leukaemia, cancer worldwide. There has to be informed decision done in making productive usage of Hela cells, where it heads on specific focus on extended potential utilisation of information and opportunity to make informed decision regarding treatments. It has been found to hold power among transformation in cancer patients, where early detection and further advancement holds huge importance for analysed growth among studies for gaining stronger functional knowledge (Al-Oqail and et.al, 2021). As healthcare providers, there has been found specific responsibility to make sure patients and families have understood genetic information, offer consent for further vital usage among treatments.The course of treatment for cancer, specified focus on fact that doctors within medical science have been able to evolve towards advanced cancer treatments based on proper ethical usage.There are specific challenges raised about medical samples which have been found to be taken without consent, which has to be further taken as per discoveries based on tissues potential usage. Ethical issues have been found to be highly crucial for strengthening effective utilisation of cells within extended medical advanced research, where professionals have been stringently evolving. The practical medical usage of Hela Cells have been potentially done by further extended utilisation of ethical format, and developingpropersynchronizedmedicalusageamongnewtreatments(Aboutalebi, FTeimouri and Pooladi, 2021). Conclusion Essay research has concluded recent findings, where presence of HIV has lead to varied types of cervical cancer treatments and discovery lead to cervical cancer paves for development in anti-cancer vaccines specifically. The essay also further shed light on history, origin of Hela cells form year 1951, by Henrietta Lacks being the founder and lady behind development of Hela cells. Study also further concluded effective potential contributions of HelaCellsinresearchwithinmedicalsciencediverselyandtoimperativelydevelop strengthened vision for extended competitive abilities. Research has also summarized specific functional aspects connected within advanced medical science, where Hela cells has been potentially most significant contributed cell among creating vaccines due to immortality. Essayalsovitallydevelopedspecificfindingsconnectedontechnicalfactors, determinants specifying worked on rise, where ethical usage of cell has also opened up researchspecificparadigmsdiversely.Studyalsoconcludedpotentialutilisationand contributions in medical breakthrough, recent research on development of polio. Covid -19 vaccines and study of leukaemia, along with cancer treatments globally.
REFRENCES Books and Journals Aboutalebi, F., Teimouri, M. and Pooladi, M., 2021. Evaluation of cellular and molecular and anti-apoptotic effects of lipid nanoparticle-containing Artemisia extract in ovarian cancer cells. Al-Oqail, M.M. and et.al, ,2021. Oxidative Stress Mediated Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induced by Rosa damascena in Human Cervical Cancer HeLa Cells.Oxidative Medicine and Cellular Longevity,2021. Chen, L., and et.al, 2022. Molecular engineering of covalent organic frameworks with elevated mitochondrial-targeting for cancer cell suppression.Sensors and Actuators B: Chemical,350, p.130861. Davenport, V ., and et.al, 2021. An Assessment of InP/ZnS as Potential Anti-Cancer Therapy:QuantumDotTreatmentIncreasesApoptosisinHeLa Cells.Journal of Nanotheranostics,2(1), pp.16-32. Nott, R., 2021. “HeLa Cells 50 Years On: The Good, The Bad, and The Ugly”(2002), by John R. Masters.Embryo Project Encyclopedia. Pourhanifeh, M. H., and et.al, 2021. Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence.Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents),21(5), pp.587-596.
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Rahman, M., 2021. The Effect Of Dosage Of Mangrove Leaf Extract Avicennia Marina On The Viability Of Hela Cells.Journal of Stem Cell Research and Tissue Engineering,5(1), pp.41-51. Rahman, M., 2021. The Effect Of Dosage Of Mangrove Leaf Extract Avicennia Marina On The Viability Of Hela Cells.Journal of Stem Cell Research and Tissue Engineering,5(1), pp.41-51. Xie, B andet.al, 2021. Hollow and Porous Fe3C-NC Nanoballoons Nanozymes for Cancer Cell H2O2 Detection.Sensors and Actuators B: Chemical,347, p.130597. Yu, C., Yang, B. and Najafi, M., 2021. Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy.Basic & Clinical Pharmacology & Toxicology.