Role of Copper Ions in Blood Coagulation
Added on 2023-01-19
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Running head: HEMATOLOGY
Topic: HEMATOLOGY
Name of the Student:
Name of the University:
Author Note:
Topic: HEMATOLOGY
Name of the Student:
Name of the University:
Author Note:
1HEMATOLOGY
Abstract:
Blood coagulation is the biological process of transformation of blood from the liquid to gel
state which is usually followed by hemostasis involved by cessation of blood loss from
damaged vessels. Biological mechanism of coagulation involves the stepwise process of
adhesion, aggregation and activation which involves platelets alongside the maturation and
deposition of fibrin. One of the most important ion which facilitates the process of blood
clotting is calcium ion which acts as a chelating agent which often help in binding to the
calcium in the blood donated. Copper is an important component of blood plasma which
helps and plays an important role in various chronic liver diseases. Ceruloplasmin is the
largest contributor to the copper ions in the plasma and plays an important role in iron
metabolism. Blood contains copper containing molecules mainly proteins which contribute
to the process of copper homeostasis and potential significance regarding health and disease.
This report would revolve around the use of copper ions and their significance in blood
clotting mechanism. Moreover, the various physiological effects of the copper ions on the
process of blood coagulation has been determined. The aims of the research area has been
directed at the pharmacodynamics of the ions in blood and their metabolic pathway tracking
through use of radioactive substances.
Abstract:
Blood coagulation is the biological process of transformation of blood from the liquid to gel
state which is usually followed by hemostasis involved by cessation of blood loss from
damaged vessels. Biological mechanism of coagulation involves the stepwise process of
adhesion, aggregation and activation which involves platelets alongside the maturation and
deposition of fibrin. One of the most important ion which facilitates the process of blood
clotting is calcium ion which acts as a chelating agent which often help in binding to the
calcium in the blood donated. Copper is an important component of blood plasma which
helps and plays an important role in various chronic liver diseases. Ceruloplasmin is the
largest contributor to the copper ions in the plasma and plays an important role in iron
metabolism. Blood contains copper containing molecules mainly proteins which contribute
to the process of copper homeostasis and potential significance regarding health and disease.
This report would revolve around the use of copper ions and their significance in blood
clotting mechanism. Moreover, the various physiological effects of the copper ions on the
process of blood coagulation has been determined. The aims of the research area has been
directed at the pharmacodynamics of the ions in blood and their metabolic pathway tracking
through use of radioactive substances.
2HEMATOLOGY
Introduction:
The main aims of the research proposal outline here are
1. Separation of the components of blood through ultracentrifugation followed by
quantification of the copper ions through ultrafiltration. This is ultimately followed by
mass spectrometry for finding the molecular mass related details of copper in blood
components.
2. Using radiology to use Cu65 isotopes for understanding their role in copper transport and
their relation to blood binding components through RIA (Radio Immunosolvent Assay) and
ELISA (Enzyme linked Immuno Sorbent Assay) for pharmacodynamics and exploration of
cytoplasm, tissue as well as plasma copper analysis through quantification of Cu ions for
exploration of their metabolic pathway
Copper ions play an important role in essential metabolic functions through its
effective incorporation into various metalloenzymes and proteins. Copper ions have been
found to be linked to high levels of cholesterol as well as high levels of blood pressure. It has
an important role in neuron signaling and its role in neutropenia due to low levels of copper.
Copper deficiency is associated with various low mineral density which ultimately leads to a
high risk of osteoporosis (Sierpinska et al. 2014). According to the findings of Lindin (2016),
copper is an important component for binding with many components of blood.
Introduction:
The main aims of the research proposal outline here are
1. Separation of the components of blood through ultracentrifugation followed by
quantification of the copper ions through ultrafiltration. This is ultimately followed by
mass spectrometry for finding the molecular mass related details of copper in blood
components.
2. Using radiology to use Cu65 isotopes for understanding their role in copper transport and
their relation to blood binding components through RIA (Radio Immunosolvent Assay) and
ELISA (Enzyme linked Immuno Sorbent Assay) for pharmacodynamics and exploration of
cytoplasm, tissue as well as plasma copper analysis through quantification of Cu ions for
exploration of their metabolic pathway
Copper ions play an important role in essential metabolic functions through its
effective incorporation into various metalloenzymes and proteins. Copper ions have been
found to be linked to high levels of cholesterol as well as high levels of blood pressure. It has
an important role in neuron signaling and its role in neutropenia due to low levels of copper.
Copper deficiency is associated with various low mineral density which ultimately leads to a
high risk of osteoporosis (Sierpinska et al. 2014). According to the findings of Lindin (2016),
copper is an important component for binding with many components of blood.
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