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Heme Oxygenase in Inflammation Conditions

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Added on  2019-12-18

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Heme Oxygenase In what way can naturally occurring compounds be utilised to up-regulate heme oxygenase to serve protective role in various inflammatory conditions? The defence mechanism in the body takes the decisions and formulates the extraction of certain elements or compounds that are helpful in producing anti-inflammatory agents (Gong and et. Naturally occurring compounds The defence mechanism is initiated by the central nervous system of the human body when certain type of injury or harm has been caused in the form of stimuli (Har

Heme Oxygenase in Inflammation Conditions

   Added on 2019-12-18

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Heme Oxygenase
Heme Oxygenase in Inflammation Conditions_1
IN WHAT WAY CAN NATURALLY OCCURRING COMPOUNDS BEUTILISED TO UP-REGULATE HEME OXYGENASE TO SERVEPROTECTIVE ROLE IN VARIOUS INFLAMMATORY CONDITIONS?Introduction The central nervous system is responsible for causing a response to stimuli. Theinflammation is a defensive response that is provided to an injury which has occurred over atissue, ligament, etc. There can be different formations or reactions to these stimuli. Swelling,redness, generation of heat and pain are some of the formations that occur over surface of thebody (Choi and Alam, 1996). The response of body towards external and internal injuries causesinflammations. There are different types of compounds that are helpful in protecting the bodyfrom such inflammations or inflammatory conditions (Gaedeke, Noble and Border, 2005). Thisassessment is based on a scientific study that aims to provide understanding regarding thetechniques which are responsible for up-regulation of heme oxygenase. The defence mechanism in the body takes the decisions and formulates the extraction ofcertain elements or compounds that are helpful in producing anti-inflammatory agents (Gong andet. al., 2013). The process through which heme oxygenase can be up-regulated have beendepicted in this assessment.Naturally occurring compounds The defence mechanism is initiated by the central nervous system of the human bodywhen certain type of injury or harm has been caused in the form of stimuli (Harju and et. al.,2002). The response that is given by the body is in the form of redness or swelling or heating ofthe affected area. There are certain compound which initiate this process. These includemovement of plasma, leukocytes, etc. The nature of inflammation can be acute or chronicdepending on the type of injury caused to the patient (Kietzmann, Samoylenko and Immenschuh,2003). Heme oxyegenase (HO) An enzyme that is generated for speeding up the breaking down of heme is hemeoxygenase (Kim and et. al., 2010). The breakdown process results in production of biliverdin,ferrous iron and carbon monoxide. These are generated in conditions of metainflammation. HO2
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is also referred as rate-limiting enzymes because they end up in production of iron and carbonmonoxide. The inflammation condition is enhanced when this enzyme is generated. The centralnervous system is responsible in the production of stress proteins when certain harmful stimulihas been addressed by the human body (Lang and et. al., 2005). HO is a system that acts likeantioxidants. They are also responsible in regulating the vascular tone which is enhances theprotective responses. The catalytic reaction that is responsible in breaking down iron and carbon monoxideaids inflammatory conditions. In order to prevent severe health conditions, the nervous systemregulates the inflammations (Martin and et. al., 2004). HO is a catalyst in this break downprocess. Belonging to the stress protein family, the generation or occurrence of this compoundtakes place only when injuries or harmful stimuli is subjected towards the body. There are threeisoforms of HO are HO-1, HO-2 and HO-3. The compound is not only helpful in production ofiron and heme but also helpful in regulation of various physiological and pathophysiologicalprocesses (Paine and et. al., 2010). There are different conditions in which isoforms of HO are produced and found. Theaffected area is deformed or disoriented due to injury (Poss and Tonegawa, 1997). Cases of liverinflammation are regulated by production of HO-1 and iron. The compound iron is degraded intoiron and carbon monoxide with help of heme oxygenase. This is further utilised in producing andregulating the inflammation conditions at liver (Raju, McCoubrey and Maines, 1997). Being acrucial organ of the body, any damage caused to liver can even result in death of the person.Hence, this protective mechanism is initiated so that quick medical help or attention can begrabbed by the patient and certain solution can be acquired.Role of heme oxygenase in protecting inflammatory conditions There are various roles of HO when its comes to protection and inflammations. Apartfrom being an enzyme and catalyst in the breakdown process, this naturally occurring compoundis responsible for liberation of certain compounds that aid pathological and physiologicalprocesses (Xia and et. al., 2007). The physiological processes are the ones in which livingorganisms and their body functions are involved. On the other hand, pathological processes arecertain invasions which are conducted by microorganisms which are pathogenic in nature. Often3
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