How We Treat Hodgkin Lymphoma

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Hodgkin lymphoma and chemotherapy- Factsheet
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Abstract
Introduction- The circulatory system comprises of the heart blood and blood vessels. The heart is
made up of cardiac cells that play an important role in circulating lymph and blood throughout
the body.
Summary- Hodgkin lymphoma refers to a cancer that affects the lymphatic system, which is the
significant component of the immune system, and some common signs and symptoms include
fever, severe itching, unexplained weight loss, night sweats, persistent fatigue, and swelling of
lymph nodes, without any pain. Although there is no definite reason for occurrence of this
illness, environmental associations and genetic susceptibility has been correlated with an
increase likelihood of suffering from Hodgkin lymphoma. It occurs due to B cell clonal
transformation that eventually triggers the generation of binucleated and pathognomic Reed-
Sternberg cells. Doxorubicin is the standard drug during chemotherapy for Hodgkin lymphoma,
and it acts by binding to nucleic acids, particularly by intercalation of anthracycline nucleus, with
the double helix of the DNA. Intercalation caused due to doxorubicin inhibits topoisomerase II
enzyme that is particularly responsible for relaxation of supercoil present in the DNA, for the
purpose of transcription.
Target audience- Nursing professionals have been selected as the target audience, since they are
frontline healthcare personnel who are directly involved in the delivery of care to patients,
besides fostering communication with the family members.
Conclusion- Thus, it can be concluded that doxorubicin proves effective in the management of
Hodgkin lymphoma, and should be appropriately administered by nurses, in order to improve
survival rates of patients.

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Keywords: Hodgkin lymphoma, chemotherapy, doxorubicin

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Table of Contents
Homeostasis.....................................................................................................................................4
Pathophysiology..............................................................................................................................4
Pharmacology..................................................................................................................................6
Drug name...................................................................................................................................6
Pharmacodynamics......................................................................................................................6
Pharmacokinetics.........................................................................................................................7
Route of Administration..............................................................................................................8
Indications, contraindications, precautions and side effects........................................................8
Contraindications.........................................................................................................................9
Lifestyle changes.............................................................................................................................9
Implications...................................................................................................................................10
Conclusion.....................................................................................................................................10
References......................................................................................................................................11