Assignment Treatment of Hyperglycemia 2022

Running head: TREATMENT OF HYPERGLYCEMIA
TREATMENT OF HYPERGLYCEMIA
Name of the Student
Name of the University
Author note

TREATMENT OF HYPERGLYCEMIA1
The clinical question- In patients of age above 65 years, is sulfonylurea more
effective than metformin?
Article- Orkaby, A. R., Cho, K., Cormack, J., Gagnon, D. R., & Driver, J. A.
(2017). Metformin vs sulfonylurea use and risk of dementia in US veterans
aged≥ 65 years with diabetes. Neurology, 89(18), 1877-1885.
The high blood sugar or hyperglycemia effects mostly the persons who are already suffering
from diabetes mellitus. There are several factors which lead to the occurrence of hyperglycemia
including the food that the patient is taking, the physical activities of the patients, other illness,
the medications or skipping the medications and not taking the medicines for lowering the
glucose levels of the patient (Thorpe, et al., 2015). I have found this article after doing lots of
researches on the disease hyperglycemia by considering different conditions of the disease, like
the current status of the disease, the rate of people suffering from diabetes, the side effects of the
medicines that are used to treat diabetes and also the other commodities associated with diabetes
(Kowall, Rathmann & Kostev, 2015). I have found so many diseases associated with diabetes.
Because of regular intake of the anti-diabetic medicines the risk of occurring of other diseases
also increases. Sulfonylurea and metformin are the medicines which are mostly used for treating
diabetes, the effectiveness of these two medicines are different and also chances of occurring of
other diseases are also increased (Lu et al., 2018). I have searched different databases for finding
papers but I got this paper from PubMed.
I got different papers must I have not used the other papers as the information provided in
all those articles were not much relevant to the developed research question. I found this article

TREATMENT OF HYPERGLYCEMIA2
to be the relevant one. Before finding this article I have reviewed the literature behind this topic.
The keywords that were used for doing the literature review are hyperglycemia, medicine
metformin, sulfonylurea and old people. The article that I have chosen is Orkaby, A. R., Cho, K.,
Cormack, J., Gagnon, D. R., & Driver, J. A. (2017). Metformin vs sulfonylurea use and risk of
dementia in US veterans aged≥ 65 years with diabetes. Neurology, 89(18), 1877-1885. This
paper is discussing about the side effects of the drugs metformin and sulfonylurea. These two
drugs are the most potential medicines of diabetes and this paper discusses by which medicine is
more potential in causing dementia to a diabetic patient. The objective of this paper is to
determine whether metformin or sulfonylurea is more effective to incidences of dementia to the
patients suffering from hyperglycemia. The study is a cohort study which involves the US
veterans and who are above 65 years of age. All of the patients that were involved in the
experiment were suffering hyperglycemia but none of them were suffering from dementia which
is a major comorbid disease of type II diabetes. The patients were kept under the medications of
both the medicines. 17200 diabetic patients were kept under the medication of metformin and
11400 diabetic patients were kept under the medicine sulfonylurea. The mean age of the patients
was 73.5 years and the mean HbA1C was 6.8%. The follow up was done after 2 years of the
completion of therapy. After the average follow up of 5 years, diagnosis of 4906 cases were
done. For the patients less than 75 years of age the crude hazard ratio of metformin and
sulfonylurea was 0.67 and of the patients above 75 years the crude hazard ratio was 0.78. Lower
risk of dementia was also found to the diabetic young veterans and had the renal functions were
also good.
The study design of this experiment is a cohort study. In the methodology, the diabetes
medications were found using the National Veteran Administration clinical and Administrative